Zobrazeno 1 - 10 of 71 pro vyhledávání: '"D S, Pepper"'
1
Protein modification during antiviral heat bioprocessing
Autor: C M, Smales, D S, Pepper, D C, James
Publikováno v: Biotechnology and bioengineering. 67(2)
Heat treatment is routinely used in the preparation of therapeutic protein biopharmaceuticals as a means of viral inactivation. However, in undertaking virucidal heat treatments, a balance must be found between the bioprocessing conditions, virus kil
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::70ca359e764c39308e19cd7080b8d9e6
https://pubmed.ncbi.nlm.nih.gov/10592515
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2
Preliminary assessment of whole-blood, red-cell and platelet- leucodepleting filters for possible induction of prion release by leucocyte fragmentation during room temperature processing
Autor: C V, Prowse, V S, Hornsey, O, Drummond, I R, MacGregor, D S, Pepper, G R, Barclay, H, Bethel, B, Walker, G, Barnard, L, Kirby, J, Hope
Publikováno v: British journal of haematology. 106(1)
Universal leucodepletion is being introduced in the U.K. to reduce a theoretical risk of Creutzfeldt-Jakob disease (CJD) transmission. If CJD infectivity is associated with leucocytes, any cell fragmentation associated with filtration could reduce th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fede322493b6e9873e3e7bfbc13f03fb
https://pubmed.ncbi.nlm.nih.gov/10444194
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3
Virus removal from bioproducts using ultrafiltration membranes modified with latex particle pretreatment
Autor: S R, Bellara, Z, Cui, S L, MacDonald, D S, Pepper
Publikováno v: Bioseparation. 7(2)
Ultrafiltration is an attractive process for virus removal from bioproducts owing to its high throughput as well as the fact that the operation is carried out under ambient conditions (damage to proteins is highly limited). The principal concern rega
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c27222da376dbdacf039a7a63a65b912
https://pubmed.ncbi.nlm.nih.gov/9763696
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5
Human vascular endothelial cells catabolise exogenous glycosaminoglycans by a novel route
Autor: J, Dawes, D S, Pepper
Publikováno v: Thrombosis and haemostasis. 67(4)
Heparin and other anticoagulant glycosaminoglycans were radiolabelled with 125I and their catabolism by human vascular endothelial cells in culture was studied. Heparin, heparan sulphate and pentosan polysulphate were associated with the cellular fra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e92c98ab19df734ea27581e58abcfb05
https://pubmed.ncbi.nlm.nih.gov/1378652
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6
Beta-thromboglobulin and platelet factor 4
Autor: D. S. Pepper, C. V. Prowse
Publikováno v: ECAT Assay Procedures A Manual of Laboratory Techniques ISBN: 9789401053303
These two low molecular weight basic proteins are found almost exclusively in the alpha-granules of platelets and represent two of the earliest examples of the group of proteins now known collectively as the small inducible gene (SIG) family of prote
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e8c9503c5df5e319e5323223920550c
https://doi.org/10.1007/978-94-011-2992-3_3
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7
Spectrophotometric Determination of Factor Xa Generation in Factor IX Concentrates
Autor: D. S. Pepper, Ann Howie, D. Banhegyi
Publikováno v: Thrombosis and Haemostasis. 37:535-540
SummaryPrevious work from this department, concerned with testing the potential thrombogenicity of therapeutic factor IX concentrates, demonstrated that following recalcification of factor IX concentrates thrombin was generated within 3-30 minutes of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d47778e5291f6aeffce98d6f04e61de6
https://doi.org/10.1055/s-0038-1649263
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8
Three Approaches to the Radioimmunoassay of Human β-Thromboglobulin
Autor: C.A. Ludlam, S. Moore, A.E. Bolton, J. D. Cash, D. S. Pepper
Publikováno v: British Journal of Haematology. 33:233-238
Three radioimmunoassays for the measurement of beta-thromboglobulin are described. The standard method, using antiserum in solution, could be used to measure plasma concentrations of beta-thromboglobulin with the results available after 2-3 d. The us
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0853ab475641e1deb1ab88f73a88a00
https://doi.org/10.1111/j.1365-2141.1976.tb03534.x
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9
Chromatographie and Electrophoretic Properties of Synthetic Human Fibrinopeptides
Autor: D. S. Pepper, A. B. Kay, Robin McKenzie
Publikováno v: Thrombosis and Haemostasis. 32:651-658
SummarySome properties of synthetic human fibrinopeptides were studied by thin-layer chromatography, thin-layer electrophoresis and low voltage and high voltage paper electrophoresis. The Rf values and electrophoretic mobilities of the peptides in th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7acf1b0db19c0131bf6596cc5415aa95
https://doi.org/10.1055/s-0038-1647733
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10
The Identification of Fibrinopeptide B as a Chemotactic Agent Derived from Human Fibrinogen
Autor: D. S. Pepper, Robin McKenzie, A. B. Kay
Publikováno v: British Journal of Haematology. 27:669-677
Chemotactic activity for human peripheral blood leucocytes was generated by the action of thrombin on human fibrinogen, a reaction known to release low molecular weight fibrinopeptides. Following gel filtration of the clot supernatant most of the act
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6844f6ec54505e8eede15f393d2c938c
https://doi.org/10.1111/j.1365-2141.1974.tb06633.x
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