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Autor:
N S, Chandel, D S, McClintock, C E, Feliciano, T M, Wood, J A, Melendez, A M, Rodriguez, P T, Schumacker
Publikováno v:
The Journal of biological chemistry. 275(33)
During hypoxia, hypoxia-inducible factor-1alpha (HIF-1alpha) is required for induction of a variety of genes including erythropoietin and vascular endothelial growth factor. Hypoxia increases mitochondrial reactive oxygen species (ROS) generation at