Zobrazeno 1 - 10
of 68
pro vyhledávání: '"D S, Longnecker"'
Autor:
Kyle S. MacLea, Ronald J. Krieser, Alan Eastman, J. L. Fields, Steven Fiering, D. S. Longnecker
Publikováno v:
Cell Death & Differentiation. 9:956-962
Deoxyribonuclease IIalpha (DNase IIalpha) is one of many endonucleases implicated in DNA digestion during apoptosis. We produced mice with targeted disruption of DNase IIalpha and defined its role in apoptosis. Mice deleted for DNase IIalpha die at b
Autor:
A. Grossman, O. Pettengill, Gilles Grondin, P. Saint Jean, Adrien R. Beaudoin, D. S. Longnecker
Publikováno v:
Endocrinology. 128:1617-1622
[3H]Estradiol can bind to a specific protein in normal rat pancreatic acinar cells. Electron microscopic immunocytochemical analysis has shown this protein to be localized primarily in the rough endoplasmic reticulum and mitochondria. Rat exocrine pa
Autor:
D. S. Longnecker
Publikováno v:
Current Opinion in Gastroenterology. 6:780-784
Autor:
D S, Longnecker
Publikováno v:
Hepato-gastroenterology. 45(24)
During the last two decades, intraductal papillary-mucinous neoplasms have been recognised as a group that should be distinguished from ductal adenocarcinomas. The literature for these tumors is confusing with the use of many different terms such as
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 7(6)
The K-ras gene is mutated inor =75% of human pancreatic adenocarcinomas and in a number of hyperplastic ductal lesions from noncarcinoma patients. In this study, the incidence of K-ras mutation was determined in a spectrum of focal proliferative panc
Publikováno v:
Archives of pathologylaboratory medicine. 120(12)
Intraductal papillary-mucinous tumors in the pancreas have recently been described as a distinct entity, but the classification of these neoplasms remains under debate. Of issue is the biologic potential of these lesions and the predictability of cli
Autor:
D S, Longnecker, P G, Terhune
Publikováno v:
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 9(8)
Most primary epithelial neoplasms found in the intrahepatic and extrahepatic biliary tracts and the pancreas have similar histologic appearances. The degree of similarity of tumor types is greater than is commonly appreciated and extends to rare neop
Autor:
J L, Dunn, D S, Longnecker
Publikováno v:
Archives of pathologylaboratory medicine. 119(6)
We present a case of pancreatoblastoma in a 61-year-old man. To our knowledge, this is the oldest patient with this tumor to be reported. Originally regarded as a microadenocarcinoma, the tumor was composed of small cells, sometimes in acinar groups
Publikováno v:
Oncology research. 6(9)
Transgenic mice bearing the rat elastase I promoter - SV40 T-antigen (ELSV) fusion gene develop pancreatic acinar cell carcinomas by 3-6 months of age. In other animal models of pancreatic cancer, cholecystokinin (CCK) has been shown to be a tumor pr
Publikováno v:
Cancer research. 53(17)
Cholecystokinin (CCK) has been shown to stimulate the growth of both normal pancreas and azaserine-induced putative preneoplastic pancreatic lesions in the rat. The present study was performed to determine whether these effects are mediated by way of