Zobrazeno 1 - 10
of 26
pro vyhledávání: '"D S, Duch"'
Publikováno v:
Analytical Letters. 25:219-230
Two different analytical methods were used to estimate reduced folates from the same cultured hepatoma cell preparation. A method based on HPLC separation of reduced folate pools in cells prelabelled with [3H]-folic acid was compared to a method base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2558bc3a83dacfe323fd52c33fc18606
https://doi.org/10.1080/00032719208018521
https://doi.org/10.1080/00032719208018521
Publikováno v:
Seminars in oncology. 23(2 Suppl 5)
Vinorelbine (Navelbine; Burroughs Wellcome Co, Research Triangle Park, NC; Pierre Fabre Medicament, Paris, France), a semisynthetic vinca alkaloid that is a potent inhibitor of mitotic microtubule polymerization, was recently approved for the treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::adc8b1b69a4f73efe1d5aeddf43aa6a4
https://pubmed.ncbi.nlm.nih.gov/8610236
https://pubmed.ncbi.nlm.nih.gov/8610236
Publikováno v:
Seminars in oncology. 23(2 Suppl 5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f8d53864094d605ba91a8f2c9c3c5cec
https://pubmed.ncbi.nlm.nih.gov/8610238
https://pubmed.ncbi.nlm.nih.gov/8610238
Publikováno v:
Cancer research. 55(24)
The purpose of this investigation was to determine whether antitumor selectivity of the third generation thymidylate synthase inhibitor 1843U89 could be enhanced by a combination of the drug with folic acid. The effects of folic acid on toxicity of 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b562edd854acff409d1090ec7f7e3cdc
https://pubmed.ncbi.nlm.nih.gov/8521402
https://pubmed.ncbi.nlm.nih.gov/8521402
Publikováno v:
Molecular pharmacology. 48(1)
The voltage- and frequency-dependent interactions of pentobarbital with voltage-gated sodium channels were examined in whole-cell patch-clamp recordings. Using rat brain IIA and rat muscle rSkM1 sodium channels expressed in stably transfected Chinese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b5de2bf7f882541a4697839175d78bcc
https://pubmed.ncbi.nlm.nih.gov/7623779
https://pubmed.ncbi.nlm.nih.gov/7623779
Publikováno v:
European journal of anaesthesiology. 12(1)
In order to begin separating the roles of membrane protein structure and membrane protein milieu in anaesthetic interactions a new planar lipid bilayer technology is being used. Membrane proteins such as sodium channels from diverse tissue sources ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d5be54617f7cdc72eca08453ffcef5a
https://pubmed.ncbi.nlm.nih.gov/7705329
https://pubmed.ncbi.nlm.nih.gov/7705329
Autor:
M, Jansen, M, Dykstra, J I, Lee, J, Stables, P, Topley, V C, Knick, R J, Mullin, D S, Duch, G K, Smith
Publikováno v:
Biochemical pharmacology. 47(6)
Clinical responses for anticancer agents are based upon tumor regression. We have investigated the potential of glycineamide ribonucleotide transformylase (GAR TFase) inhibitors to produce regressions in multiple preclinical models of colon carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f369e06adfe3082e6692ffd49702640
https://pubmed.ncbi.nlm.nih.gov/8147906
https://pubmed.ncbi.nlm.nih.gov/8147906
Autor:
D S, Duch, S, Banks, I K, Dev, S H, Dickerson, R, Ferone, L S, Heath, J, Humphreys, V, Knick, W, Pendergast, S, Singer
Publikováno v:
Cancer research. 53(4)
Studies on a series of benzoquinazoline folate analogues as inhibitors of human thymidylate synthase led to the selection of 1843U89 for further evaluation. This compound had a Ki of 90 pM versus human thymidylate synthase and was noncompetitive with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b72f60b99f9cc29dadd8899981951d00
https://pubmed.ncbi.nlm.nih.gov/8428362
https://pubmed.ncbi.nlm.nih.gov/8428362
Publikováno v:
Cancer research. 52(18)
Metabolic effects and mode of cytotoxicity of 5-deazaacyclotetrahydrofolate (5-DACTHF, BW543U76), a glycineamide ribonucleotide transformylase inhibitor, were studied in MOLT-4 cells, a human T-cell leukemia line. 5-DACTHF inhibits purine synthesis w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e00e9af9fcbfdae1fa60d46a79f74cae
https://pubmed.ncbi.nlm.nih.gov/1516046
https://pubmed.ncbi.nlm.nih.gov/1516046
Publikováno v:
The Journal of biological chemistry. 267(8)
N-Acetylserotonin (compound 1) and N-acetyldopamine (compound 7) inhibit bovine adrenal medullary sepiapterin reductase in a manner competitive with the pterin substrate and have Ki values of 0.12 and 0.4 microM, respectively. Molecular modeling sugg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a93a02cab688522f2dca2e29089913e8
https://pubmed.ncbi.nlm.nih.gov/1544933
https://pubmed.ncbi.nlm.nih.gov/1544933