Zobrazeno 1 - 10
of 83
pro vyhledávání: '"D Ross Laybutt"'
Autor:
Sarita Dhounchak, Sarah K Popp, Debra J Brown, D Ross Laybutt, Trevor J Biden, Stefan R Bornstein, Christopher R Parish, Charmaine J Simeonovic
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252607 (2021)
Heparan sulfate proteoglycans (HSPGs) consist of a core protein with side chains of the glycosaminoglycan heparan sulfate (HS). We have previously identified (i) the HSPGs syndecan-1 (SDC1), and collagen type XVIII (COL18) inside mouse and human isle
Externí odkaz:
https://doaj.org/article/68eb3c59062444408e639f2ff92b388d
Autor:
Heshan Peiris, Michael D Duffield, Joao Fadista, Claire F Jessup, Vinder Kashmir, Amanda J Genders, Sean L McGee, Alyce M Martin, Madiha Saiedi, Nicholas Morton, Roderick Carter, Michael A Cousin, Alexandros C Kokotos, Nikolay Oskolkov, Petr Volkov, Tertius A Hough, Elizabeth M C Fisher, Victor L J Tybulewicz, Jorge Busciglio, Pinar E Coskun, Ann Becker, Pavel V Belichenko, William C Mobley, Michael T Ryan, Jeng Yie Chan, D Ross Laybutt, P Toby Coates, Sijun Yang, Charlotte Ling, Leif Groop, Melanie A Pritchard, Damien J Keating
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006033 (2016)
Type 2 diabetes (T2D) is a complex metabolic disease associated with obesity, insulin resistance and hypoinsulinemia due to pancreatic β-cell dysfunction. Reduced mitochondrial function is thought to be central to β-cell dysfunction. Mitochondrial
Externí odkaz:
https://doaj.org/article/55d1108814ad40e3b162e4623311cfe8
Autor:
Andreia V Pinho, Mohammed Bensellam, Elke Wauters, Maxine Rees, Marc Giry-Laterriere, Amanda Mawson, Le Quan Ly, Andrew V Biankin, Jianmin Wu, D Ross Laybutt, Ilse Rooman
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128012 (2015)
Sirtuin 1 (Sirt1) has been reported to be a critical positive regulator of glucose-stimulated insulin secretion in pancreatic beta-cells. The effects on islet cells and blood glucose levels when Sirt1 is deleted specifically in the pancreas are still
Externí odkaz:
https://doaj.org/article/15f5cdd721a14cafbf14c0c2a5e77a80
Autor:
Jenny E Gunton, Mary Sisavanh, Rebecca A Stokes, Jon Satin, Leslie S Satin, Min Zhang, Sue M Liu, Weikang Cai, Kim Cheng, Gregory J Cooney, D Ross Laybutt, Trina So, Juan-Carlos Molero, Shane T Grey, Douglas A Andres, Michael S Rolph, Charles R Mackay
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39462 (2012)
AIMS AND HYPOTHESIS:Glucose-stimulated insulin secretion from beta-cells is a tightly regulated process that requires calcium flux to trigger exocytosis of insulin-containing vesicles. Regulation of calcium handling in beta-cells remains incompletely
Externí odkaz:
https://doaj.org/article/7e888d5d96f54d44a11c04ca0d7a1069
Autor:
Mohammed Bensellam, Bertrand Duvillié, Galyna Rybachuk, D Ross Laybutt, Christophe Magnan, Yves Guiot, Jacques Pouysségur, Jean-Christophe Jonas
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29807 (2012)
BACKGROUND:Glucose increases the expression of glycolytic enzymes and other hypoxia-response genes in pancreatic beta-cells. Here, we tested whether this effect results from the activation of Hypoxia-Inducible-factors (HIF) 1 and 2 in a hypoxia-depen
Externí odkaz:
https://doaj.org/article/a46e96628aa440de8f3eca69bb7ab864
Autor:
Lu-Ping Ren, Stanley M H Chan, Xiao-Yi Zeng, D Ross Laybutt, Tristan J Iseli, Ruo-Qiong Sun, Edward W Kraegen, Gregory J Cooney, Nigel Turner, Ji-Ming Ye
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30816 (2012)
Mitochondrial dysfunction and endoplasmic reticulum (ER) stress have been implicated in hepatic steatosis and insulin resistance. The present study investigated their roles in the development of hepatic steatosis and insulin resistance during de novo
Externí odkaz:
https://doaj.org/article/955ff7c56eb041cb93ac77a8900849de
Publikováno v:
Nutrition, Metabolism and Cardiovascular Diseases. 32:2439-2449
Betaine supplementation has been shown to enhance hepatic lipid metabolism in obese mice and improve exercise performance in healthy populations. We examined effects of betaine supplementation, alone or in combination with treadmill exercise, on the
Autor:
Amit Lalwani, Joanna Warren, David Liuwantara, Wayne J. Hawthorne, Philip J. O’Connell, Frank J. Gonzalez, Rebecca A. Stokes, Jennifer Chen, D. Ross Laybutt, Maria E. Craig, Michael M. Swarbrick, Cecile King, Jenny E. Gunton
Publikováno v:
Cell Reports, Vol 27, Iss 8, Pp 2370-2384.e6 (2019)
Summary: The development of autoimmune disease type 1 diabetes (T1D) is determined by both genetic background and environmental factors. Environmental triggers include RNA viruses, particularly coxsackievirus (CV), but how they induce T1D is not unde
Externí odkaz:
https://doaj.org/article/f99ed7866a664ac8bc67124c86dc4c4b
Publikováno v:
Biology, Vol 10, Iss 3, p 176 (2021)
Metallothioneins (MTs) are low molecular weight, cysteine-rich, metal-binding proteins whose precise biological roles have not been fully characterized. Existing evidence implicated MTs in heavy metal detoxification, metal ion homeostasis and antioxi
Externí odkaz:
https://doaj.org/article/defaf66146444f3e901eb552fb109fa0
Autor:
Mojgan Nazari, Kenneth W. Ho, Natasha Langley, Kuan M. Cha, Raymond Kodsi, Mawson Wang, D. Ross Laybutt, Kim Cheng, Rebecca A. Stokes, Michael M. Swarbrick, Jenny E. Gunton
Publikováno v:
Scientific Reports
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Beige and brown fat consume glucose and lipids to produce heat, using uncoupling protein 1 (UCP1). It is thought that full activation of brown adipose tissue (BAT) may increase total daily energy expenditure by 20%. Humans normally have more beige an