Zobrazeno 1 - 10
of 67
pro vyhledávání: '"D Ratnasinghe"'
Autor:
Neshatul Haque, Tomoki Kawai, Brian D. Ratnasinghe, Jessica B. Wagenknecht, Raul Urrutia, Luigi D. Notarangelo, Michael T. Zimmermann
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108040- (2023)
Summary: Interpreting genetic changes observed in individual patients is a critical challenge. The array of immune deficiency syndromes is typically caused by genetic variation unique to individuals. Therefore, new approaches are needed to interpret
Externí odkaz:
https://doaj.org/article/99029b4d95e64cc3971cf8da11e65139
Autor:
Brian D. Ratnasinghe, Neshatul Haque, Jessica B. Wagenknecht, Davin R. Jensen, Guadalupe K. Valdivia Esparza, Elise N. Leverence, Thiago Milech De Assuncao, Angela J. Mathison, Gwen Lomberk, Brian C. Smith, Brian F. Volkman, Raul Urrutia, Michael T. Zimmermann
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4790-4803 (2023)
Current capabilities in genomic sequencing outpace functional interpretations. Our previous work showed that 3D protein structure calculations enhance mechanistic understanding of genetic variation in sequenced tumors and patients with rare diseases.
Externí odkaz:
https://doaj.org/article/e4afc6f4318146d9b1881bfb9d51d6e8
Publikováno v:
Journal of Chemical Information and Modeling. 60:6476-6488
G-quadruplexes (GQs) are topologically diverse, highly thermostable noncanonical nucleic acid structures that form in guanine-rich sequences in DNA and RNA. GQs are implicated in transcriptional and translational regulation and genome maintenance, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3aa97246802fbee178abbe2a5ebb8236
https://doi.org/10.1021/acs.jcim.0c01064
https://doi.org/10.1021/acs.jcim.0c01064
Publikováno v:
Biophysical Journal. 120:222a-223a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c34c73eb0e6798ec22952fbdeea4cd6d
https://doi.org/10.1016/j.bpj.2020.11.1489
https://doi.org/10.1016/j.bpj.2020.11.1489
Publikováno v:
Biophysical Journal. 118:224a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2c41d432abb6230815c881eb6159630
https://doi.org/10.1016/j.bpj.2019.11.1329
https://doi.org/10.1016/j.bpj.2019.11.1329
Publikováno v:
Biophysical Journal. 116:359a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c7386c3c3bdeb20365828fda202391f
https://doi.org/10.1016/j.bpj.2018.11.1954
https://doi.org/10.1016/j.bpj.2018.11.1954
Publikováno v:
Nutrition and Cancer. 62:425-435
We evaluated the association between physical activity and breast cancer risk among 1,463 breast cancer cases and 4,862 controls in a multinational study. All subjects were asked how many times and for how long they exercised or engaged in strenuous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4443c7d45f6cf0ba43ea01ea72df5148
https://doi.org/10.1080/01635580903441295
https://doi.org/10.1080/01635580903441295
Autor:
Somdat Mahabir, Zhi-Wei Dong, Philip R. Taylor, Luke D. Ratnasinghe, You-Lin Qiao, Christian C. Abnet, Sanford M. Dawsey, Steven D. Mark
Publikováno v:
Journal of Epidemiology & Community Health. 61:737-741
Background: Stroke is the leading cause of death in Linxian, China. Although there is evidence of DNA damage in experimental stroke, no data exist on DNA repair and stroke in human populations. Aim: To assess the risk of stroke conferred by polymorph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d32cf6bd8ee39726c032f6a30282b6c
https://doi.org/10.1136/jech.2006.048934
https://doi.org/10.1136/jech.2006.048934
Autor:
Lisa Carter, Fred F. Kadlubar, Susan E. McCann, Luke D. Ratnasinghe, Christine B. Ambrosone, Nicholas P. Lang, Jihnhee Yu, Susan Nowell, Jiyoung Ahn
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 15:1217-1222
Catalase is an endogenous antioxidant enzyme that neutralizes hydrogen peroxide and is induced by oxidative challenge. A −262C → T polymorphism in the promoter region of the gene (CAT) is associated with risk of several conditions related to oxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949c0c5cbcfe264f45d912fcbf0a847b
https://doi.org/10.1158/1055-9965.epi-06-0104
https://doi.org/10.1158/1055-9965.epi-06-0104
Autor:
Steven D. Mark, Zhi-Wei Dong, Sanford M. Dawsey, Christian C. Abnet, Philip R. Taylor, Rachael Z. Stolzenberg-Solomon, Luke D. Ratnasinghe, Rama Modali, You-Lin Qiao
Publikováno v:
Cancer Letters. 216:157-164
Background: Linxian, a rural county in North Central China, has among the highest rates of esophageal squamous cell carcinoma and gastric cardia adenocarcinoma in the world. In a nested case-cohort study that originated from two cancer prevention tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51b9831f49ac961dcf3d9bf47882500
https://doi.org/10.1016/j.canlet.2004.03.012
https://doi.org/10.1016/j.canlet.2004.03.012