Zobrazeno 1 - 5
of 5
pro vyhledávání: '"D R Wada"'
Autor:
D R Wada, Timothy J. Carrothers, Daniel E. Salazar, J Shi, Shashank Rohatagi, SaeHeum Song, Reinilde Heyrman
Publikováno v:
Clinical Pharmacology & Therapeutics. 91:250-256
Modeling and simulation were used extensively in the development of an indication for the use of olmesartan medoxomil in pediatric patients with hypertension. Simulations based on models developed in adult patients indicated that two dose groups were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7c1aa45b4f0b3430391e237e569880
https://doi.org/10.1038/clpt.2011.220
https://doi.org/10.1038/clpt.2011.220
Publikováno v:
Clinical pharmacology and therapeutics. 90(6)
High development cost, low development success, cost-disciplined health-care policies, and intense competition demand an efficient drug development process. New compounds need to bring value to patients by being safe, efficacious, and cost-effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e257220e27a42731807705d2c0f48e57
https://pubmed.ncbi.nlm.nih.gov/22048231
https://pubmed.ncbi.nlm.nih.gov/22048231
Autor:
J W, Mandema, D R, Wada
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 275(3)
This investigation was carried out to characterize the rate and extent of acute tolerance development to the pharmacodynamics of alfentanil in the rat with the electroencephalogram (EEG) as a measure of alfentanil's effects on the central nervous sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6207d4973bf498b52ec65dc34d5e039a
https://pubmed.ncbi.nlm.nih.gov/8531080
https://pubmed.ncbi.nlm.nih.gov/8531080
Publikováno v:
Anesthesia and analgesia. 77(6)
Flumazenil, a benzodiazepine antagonist, clearly reverses midazolam-induced sedation; reversal of ventilatory depression has not been as well demonstrated. Thirty-two subjects completed this randomized, double-blind, placebo-controlled study investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b070409443051afff0bac4a2475829b3
https://pubmed.ncbi.nlm.nih.gov/8250314
https://pubmed.ncbi.nlm.nih.gov/8250314
Publikováno v:
Anesthesia & Analgesia. 77:1207
Flumazenil, a benzodiazepine antagonist, clearly reverses midazolam-induced sedation; reversal of ventilatory depression has not been as well demonstrated. Thirty-two subjects completed this randomized, double-blind, placebo-controlled study investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5062fcf1646f8dd6a208c32377c9ef5
https://doi.org/10.1213/00000539-199312000-00022
https://doi.org/10.1213/00000539-199312000-00022