Zobrazeno 1 - 10 of 177 pro vyhledávání: '"D R Morgan"'
1
Lewis Acid-Mediated Cyclization of Allenyl Aryl Ketones
Autor: Timothy D. R. Morgan, Mariam Zaky, Zhe Li, Russell J. Boyd, D. Jean Burnell, François M. LeFort
Publikováno v: The Journal of Organic Chemistry. 84:13665-13675
The cyclization of a series of nonheterocyclic allenyl aryl ketones was examined using boron trifluoride etherate and indium triflate to mediate the reaction. Yields with BF3 were low in most instances due mainly to competitive destruction of the sub
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22b69dc37f02a41529e2c3684209d4f
https://doi.org/10.1021/acs.joc.9b01900
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3
A synthetically lethal nanomedicine delivering novel inhibitors of polynucleotide kinase 3'-phosphatase (PNKP) for targeted therapy of PTEN-deficient colorectal cancer
Autor: Marco Paladino, Forughalsadat Sanaee, Dennis G. Hall, Frank R. Jirik, Michael Weinfeld, Rajam S. Mani, Gary R. Martin, Timothy D. R. Morgan, Igor M. Paiva, Sams M.A. Sadat, Afsaneh Lavasanifar, Zahra Shire, Feridoun Karimi-Busheri
Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 334
Phosphatase and TENsin homolog deleted on chromosome 10 (PTEN) is a major tumor-suppressor protein that is lost in up to 75% of aggressive colorectal cancers (CRC). The co-depletion of PTEN and a DNA repair protein, polynucleotide kinase 3′-phospha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e4743e3ef825bce183d6c82ea4dc4e
https://pubmed.ncbi.nlm.nih.gov/33933518
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4
The welfare of wild animals in zoological institutions: are we meeting our duty of care?
Autor: C. McKenna, D. R. Morgan, L. Kavanagh, T. A. Blackett
Publikováno v: International Zoo Yearbook. 51:187-202
Across the world there are many different species of wild animals maintained in zoological institutions of one sort or another for a variety of purposes. Their welfare is directly dependent upon the quality of life they experience, which in turn is d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::342b68800964102b2f68d1fa2dfcdfcd
https://doi.org/10.1111/izy.12143
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5
Nanoencapsulation of Novel Inhibitors of PNKP for Selective Sensitization to Ionizing Radiation and Irinotecan and Induction of Synthetic Lethality
Autor: Michael Weinfeld, Afsaneh Lavasanifar, Mohammad Reza Vakili, Timothy D. R. Morgan, Dennis G. Hall, Zahra Shire
Publikováno v: Molecular pharmaceutics. 15(6)
There is increasing interest in developing and applying DNA repair inhibitors in cancer treatment to augment the efficacy of radiation and conventional genotoxic chemotherapy. However, targeting the inhibitor is required to avoid reducing the repair
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5821f409b22ae9fe1d4a73bc1815ade
https://pubmed.ncbi.nlm.nih.gov/29688721
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6
Scope and Mechanism of a True Organocatalytic Beckmann Rearrangement with a Boronic Acid/Perfluoropinacol System under Ambient Conditions
Autor: Timothy D. R. Morgan, Xiaobin Mo, Dennis G. Hall, Hwee Ting Ang
Publikováno v: Journal of the American Chemical Society. 140(15)
Catalytic activation of hydroxyl functionalities is of great interest for the production of pharmaceuticals and commodity chemicals. Here, 2-alkoxycarbonyl- and 2-phenoxycarbonyl-phenylboronic acid were identified as efficient catalysts for the direc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a558347c50afeb0db6f36ff0dc2321f9
https://pubmed.ncbi.nlm.nih.gov/29565116
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7
Interception of Nazarov Reactions of Allenyl Vinyl Ketones with Dienes: (3+2)- versus (4+3)-Cycloaddition and Subsequent Rearrangement
Autor: Russell J. Boyd, François M. LeFort, D. Jean Burnell, Zhe Li, Timothy D. R. Morgan, Vanessa M. Marx
Publikováno v: European Journal of Organic Chemistry. 2015:2952-2959
Capture of the cyclic oxyallyl cation intermediates from the BF3-mediated Nazarov reactions of three allenyl vinyl ketones with various dienes was accomplished by (3+2)- and (4+3)-cycloaddition. The relative amounts of these types of products were de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0003ddcc7bf18e1191d939f002bbbda3
https://doi.org/10.1002/ejoc.201403618
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8
Torquoselectivity in the Nazarov Reactions of Allenyl Vinyl Ketones
Autor: Timothy D. R. Morgan, D. Jean Burnell, Giselle H. Ardagh, Russell J. Boyd, Luc M. LeBlanc
Publikováno v: The Journal of Organic Chemistry. 80:1042-1051
Nazarov reactions mediated by BF3-etherate of a series of carbon-substituted allenyl vinyl ketones provided intermediates in which substituents on the termini of the allenes had rotated away from the vinyl moieties, and these intermediates were trapp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f784c4fbdaf900c6e0108f31a8cc0a5
https://doi.org/10.1021/jo502532a
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10
Evaluation of Zoletil and other injectable anaesthetics for field sedation of brushtail possums (Trichosurus vulpecula)
Autor: D. R. Morgan, S. Scobie, D. G. Arthur
Publikováno v: Animal Welfare. 21:457-462
Ketamine has been used for many years for sedating possums captured in the wild in New Zealand, but its recent reclassification as a Class III drug under the Misuse of Drugs Act (1975) has made its continued use impractical. Consequently, four other
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::627a6f42b06b6723cc5208729e6b1d87
https://doi.org/10.7120/09627286.21.4.457
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