Evolution of MET and NRAS gene amplification as acquired resistance mechanisms in EGFR mutant NSCLC

Autor: T. L. Peters, T. Patil, A. T. Le, K. D. Davies, P. M. Brzeskiewicz, H. Nijmeh, L. Bao, D. R. Camidge, D. L. Aisner, R. C. Doebele

Publikováno v: npj Precision Oncology, Vol 5, Iss 1, Pp 1-6 (2021)

Abstract EGFR mutant non-small cell lung cancer patients' disease demonstrates remarkable responses to EGFR-targeted therapy, but inevitably they succumb to acquired resistance, which can be complex and difficult to treat. Analyzing acquired resistan

Externí odkaz: https://doaj.org/article/a60d71a2c6b74878abf284abc023a3a1

The impact of socioeconomic status on access to cancer clinical trials

Autor: Katherine Sharrocks, Sophie Papa, D R Camidge, James Spicer

Publikováno v: British Journal of Cancer
Sharrocks, K, Spicer, J, Camidge, D R & Papa, S 2014, ' The impact of socioeconomic : status on access to cancer clinical trials ', British Journal of Cancer, vol. 111, no. 9, pp. 1684-7 . https://doi.org/10.1038/bjc.2014.108

Cancer clinical trials enable the development of novel agents for the potential benefit of cancer patients. Enrolment in a trial offers patients the chance of superior efficacy coupled to the risk of unanticipated toxicity. For trial results to be ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61e4a2ec42dbb38039a1f7bfe347ba7
https://doi.org/10.1038/bjc.2014.108

Hospital admissions and deaths relating to deliberate self-harm and accidents within 5 years of a cancer diagnosis: a national study in Scotland, UK

Autor: S Frame, M. M. Bain, D N Bateman, D R Camidge, D L Stockton, R. J. Wood

Publikováno v: British Journal of Cancer

The risk of suicide in cancer patients has been reported as elevated in several countries. These patients are exposed to many medicines that may confuse or provide a means for harm, potentially also increasing their risk from accidents. Ratios of obs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94866404230b46ccd58660a6b7fb35e
http://europepmc.org/articles/PMC2360070

Assessing proliferation, cell-cycle arrest and apoptotic end points in human buccal punch biopsies for use as pharmacodynamic biomarkers in drug development

Autor: D R Camidge, P J Laud, D Johnstone, A. Hughes, Jim Growcott, John R. Foster, K J Randall, Mike Pemberton

Publikováno v: British Journal of Cancer

Easily accessible normal tissues expressing the same molecular site(s) of drug action as malignant tissue offer an enhanced potential for early proof of anticancer drug mechanism and estimation of the biologically effective dose. Studies were underta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c48a403803166c3e4d15d6127ec9b9b2
http://europepmc.org/articles/PMC2361555

The epidemiology of self-poisoning in the UK

Autor: D. N. Bateman, R. J. Wood, D. R. Camidge

Publikováno v: British Journal of Clinical Pharmacology. 56:613-619

Self-poisoning by ingestion or inhalation is common, and it is important to study its various epidemiological manifestations with clear definitions. Data on fatal self-poisonings are recorded nationally within the UK and are codified according to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7c705e52d8d1d9260c7e1606f242659
https://doi.org/10.1046/j.1365-2125.2003.01910.x