Zobrazeno 1 - 2
of 2
pro vyhledávání: '"D R, Yarwood"'
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 3:27-36
Cyclin dependent kinases such as Cdk4 are involved in the control of cell cycle progression, and misregulation of Cdk4 has been implicated in many types of cancers. In the present study, we report the development of a novel homogeneous assay using an
Autor:
T C, Pellas, W, Boyar, J, van Oostrum, J, Wasvary, L R, Fryer, G, Pastor, M, Sills, A, Braunwalder, D R, Yarwood, R, Kramer, E, Kimble, J, Hadala, W, Haston, R, Moreira-Ludewig, S, Uziel-Fusi, P, Peters, K, Bill, L P, Wennogle
Publikováno v:
The Journal of Immunology. 160:5616-5621
Novel recombinant human C5a receptor antagonists were discovered through modification of the C terminus of C5a. The C5a1–71T1M,C27S,Q71C monomer, (C5aRAM; CGS 27913), was a pure and potent functional antagonist. The importance of a C-terminal cyste