Zobrazeno 1 - 10
of 18
pro vyhledávání: '"D R, Van Harken"'
Publikováno v:
Antimicrobial Agents and Chemotherapy. 19:1004-1012
Sarmoxicillin, an amoxicillin prodrug, is the methoxymethyl ester of hetamoxicillin. Esterification converted amoxicillin from an amphoteric to a cationic compound and resulted in a 30- to 600-fold increase in lipid partitioning. Oral absorption stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705bcd28370eff1637cb725d7142f480
https://doi.org/10.1128/aac.19.6.1004
https://doi.org/10.1128/aac.19.6.1004
Autor:
L. W. Schneider, Robert S. Pearlman, Jane W. Newburger, D. R. Van Harken, A. Martin, R D Smyth, Salomon A Stavchansky, G. H. Hottendorf
Publikováno v:
Journal of Pharmaceutical Sciences. 73:169-173
The relative bioavailability of sarpicillin (the methoxymethyl ester of hetacillin) from three different oral dosage forms was compared in humans employing a three-way crossover study design. Each unit dose contained 250 mg of sarpicillin in terms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d0a86670649ab79ae28a4546b485b3
https://doi.org/10.1002/jps.2600730208
https://doi.org/10.1002/jps.2600730208
ROLE OF THE INTRACELLULAR DISTRIBUTION OF HEPATIC CATALASE IN THE PEROXIDATIVE OXIDATION OF METHANOL
Autor:
Adeeb Bassili Makar, Gilbert J. Mannering, W. D. Watkins, D. R. Van Harken, T. R. Tephly, J. I. Goodman
Publikováno v:
Annals of the New York Academy of Sciences. 168:265-280
Previous to 1950, when Bonnichsenl isolated crystalline alcohol dehydrogenase (ADH) and showed that it did not react with methanol,$ it was believed that the ADH system was responsible for the oxidation of all primary aliphatic alcohols, including me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd253ad6b486ea866a3776df71b45421
https://doi.org/10.1111/j.1749-6632.1969.tb43114.x
https://doi.org/10.1111/j.1749-6632.1969.tb43114.x
Publikováno v:
Journal of Biological Chemistry. 244:2278-2285
1. Livers from normal and alloxan diabetic rats were perfused in vitro with a medium in which the concentration of free fatty acid was maintained at relatively constant levels by the infusion of a complex of oleic acid and bovine serum albumin. Conce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::497c4e3a27025aa5c5b2cc48bacf4ac3
https://doi.org/10.1016/s0021-9258(19)78223-4
https://doi.org/10.1016/s0021-9258(19)78223-4
Publikováno v:
Current therapeutic research, clinical and experimental. 18(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::14a8c2539662cac075b8ff741bbaa086
https://pubmed.ncbi.nlm.nih.gov/809250
https://pubmed.ncbi.nlm.nih.gov/809250
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 8(4)
The metabolism and elimination of 3H-butorphanol (levo-3, 14-dihydroxy-N-(cyclobutylmethyl)[15-3H]morhinan) tartrate were determined in man after therapeutic im (2 mg) and iv (1 mg) doses. As judged from urinary excretion of radioactivity, the im dos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::43f01c9c4863b16c5807b5e2c713387f
https://pubmed.ncbi.nlm.nih.gov/6105056
https://pubmed.ncbi.nlm.nih.gov/6105056
Autor:
J.T. Doluisio, D. R. Van Harken, W. O. Griffen, G. H. Hottendorf, Lewis W. Dittert, B. E. Cabana, David W. A. Bourne
Publikováno v:
Journal of pharmacokinetics and biopharmaceutics. 3(6)
A pharmacokinetic model was developed to describe the absorption, distribution, metabolism, and excretion of cephapirin and its major metabolite, desacetylcephapirin, following intravenous and intramuscular administration of cephapirin in healthy adu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49ad3b28c0cdbebf3078b2e0c53ad47
https://pubmed.ncbi.nlm.nih.gov/1206478
https://pubmed.ncbi.nlm.nih.gov/1206478
Publikováno v:
Antimicrobial agents and chemotherapy. 10(2)
Comparative drug disposition studies in mice, rats, dogs, and humans indicate that cephapirin, a new semisynthetic cephalosporin antibiotic that exhibits broad-spectrum antimicrobial activity, is metabolized to desacetylcephapirin in these species. P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76428acbd296ec7a4742f555baaa46e5
https://pubmed.ncbi.nlm.nih.gov/984774
https://pubmed.ncbi.nlm.nih.gov/984774
Autor:
Morris Pfeffer, R D Smyth, Joyce A. Buckley, Adnan S. Dajani, D. R. Van Harken, M C Thirumoorthi, Roger E. Bawdon
We studied the pharmacokinetics of intramuscular ceforanide in 46 infants, children, and adolescents, ranging in age from 1 month to 17 years. After the subjects were given 20-mg doses of ceforanide per kg, the mean peak plasma concentration was 56.3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07c376d68e505503998e4a9dde56847
https://europepmc.org/articles/PMC181874/
https://europepmc.org/articles/PMC181874/
Publikováno v:
Toxicology and applied pharmacology. 28(2)
A new preclinical safety evaluation procedure for single-dose studies in humans is described. By integrating pharmacokinetic analyses and cardiovascular assessment with single-dose tolerance and short-term, multiple-dose toxicologic assessments in ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340fe123358f725880cd0be4fa443a89
https://pubmed.ncbi.nlm.nih.gov/4212198
https://pubmed.ncbi.nlm.nih.gov/4212198