Zobrazeno 1 - 10
of 47
pro vyhledávání: '"D R, Thakker"'
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(10)
Recently, sandwich-cultured (SC) rat hepatocytes have been used as an in vitro model to assess biliary excretion of drugs and xenobiotics. The purpose of the present study was to validate the use of SC rat hepatocytes for the in vitro assessment of P
Publikováno v:
Pharmaceutical research. 15(1)
The tight junctions in the intestinal epithelium represent highly specialized intercellular junctions. Ranitidine, an H2-antagonist, causes a tightening of the tight junctions. Hence, we have investigated the effect of ranitidine and other H2-antagon
Publikováno v:
Pharmaceutical research. 14(6)
This study is concerned with cellular delivery/generation of 2'-azido-2'-deoxyuridine and -deoxycytidine diphosphate (N3UDP or N3CDP), potent inhibitors of ribonucleotide reductase. It characterizes the phosphorylation steps involved in the conversio
CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells
Autor:
L S, Gan, M A, Moseley, B, Khosla, P F, Augustijns, T P, Bradshaw, R W, Hendren, D R, Thakker
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(3)
Transport of cyclosporin A (CsA) across Caco-2 cells is modulated by its directional efflux, mediated by a p-glycoprotein-like pump (Augustijns et al., Biochem. Biophys. Res. Comm. 197:360-365, 1994). In addition to this unidirectional flux, oxidativ
Autor:
D. R. Thakker, C. R. Creveling
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783642784316
The existence of methylation as a metabolic conjugation reaction was first established over a century ago when N-methylpyridinium metabolite was detected by HIS (1887) in dog urine after administration of pyridine. Since then, methyl transfer has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e575c5cffd915388b846dbbc4c58322a
https://doi.org/10.1007/978-3-642-78429-3_7
https://doi.org/10.1007/978-3-642-78429-3_7
Publikováno v:
Molecular Psychiatry. 10:714-714
Publikováno v:
Journal of Biological Chemistry. 261:178-184
Selectivity of catechol O-methyltransferase has been examined for the three ring-fluorinated norepinephrines to elucidate the role of acidity of the phenolic groups in their methylation. Substitution of fluorine at the 5-position of norepinephrine re
Publikováno v:
Chemico-Biological Interactions. 27:145-161
Through application of the exciton chirality method, absolute stereochemistry has been assigned to the (+)- and (−)-enantiomers of four of the five metabolically possible trans-dihydrodiols of the polycyclic hydrocarbon benzo[ a ]anthracene (BA). T
Autor:
D. R. Thakker, J. M. Sayer, P. E. Thomas, L K Pannell, H. Yagi, D. E. Ryan, C. Boehlert, D. M. Jerina, W. Levin, Seid Mirsadeghi
Publikováno v:
Journal of Biological Chemistry. 263:98-105
Metabolism of triphenylene by liver microsomes from control, phenobarbital(PB)-treated rats and 3-methylcholanthrene(MC)-treated rats as well as by a purified system reconstituted with cytochrome P-450c in the absence or presence of purified microsom
Publikováno v:
Journal of Biological Chemistry. 263:3676-3683
Oxidative metabolism of the carcinogen 6-fluorobenzo[c]phenanthrene (6-FB[c]Ph) was compared with that of benzo[c]phenanthrene (B[c]Ph) to elucidate the enhancement of carcinogenicity of B[c]Ph by the 6-fluoro substituent. Liver microsomes from untre