Phase I trial of SU14813 in patients with advanced solid malignancies

Autor: P. Lasch, Nicoletta Brega, Walter Fiedler, I. van der Horst, D. R. Shalinsky, G. Giaccone, Antonello Abbattista, Carsten Bokemeyer, Epie Boven, R. Courtney

Publikováno v: Fiedler, W, Giaccone, G, Lasch, P, van der Horst, I, Brega, N, Courtney, R, Abbattista, A, Shalinsky, D R, Bokemeyer, C & Boven, E 2011, ' Phase I trial of SU14813 in patients with advanced solid malignancies ', Annals of Oncology, vol. 22, no. 1, pp. 195-201 . https://doi.org/10.1093/annonc/mdq313
Annals of Oncology, 22(1), 195-201. Oxford University Press

this phase I, open-label, dose-escalation study investigated SU14813, an oral multitargeted tyrosine kinase inhibitor, in adults with solid tumors.seventy-seven patients received once-daily SU14813, either for 4 weeks followed by 1 week off treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c68c017bf6f336a283ba46c3efe3ae
https://research.vumc.nl/en/publications/ac8ac558-d771-4190-a718-a352220abfe1

In vitro modulation of cisplatin accumulation in human ovarian carcinoma cells by pharmacologic alteration of microtubules

Autor: D. R. Shalinsky, Jeffrey A. Jones, A. Jekunen, R D Christen, F B Thiebaut, Stephen B. Howell

Publikováno v: Journal of Clinical Investigation. 92:431-440

We have previously shown that forskolin and 3-isobutyl-1-methylxanthine (IBMX) increased accumulation of cisplatin (DDP) in DDP-sensitive 2008 human ovarian carcinoma cells in proportion to their ability to increase cAMP. Since the major function of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5644b6c8bf7952292b93aa1f45cac6
https://doi.org/10.1172/jci116585

Selective modulation of vinblastine sensitivity by 1,9-dideoxyforskolin and related diterpenes in multidrug resistant tumour cells

Autor: Stephen B. Howell, A. Jekunen, D. R. Shalinsky, J. E. Alcaraz, D. D. Heath

Publikováno v: British Journal of Cancer

The ability of 1,9-dideoxyforskolin (DDF), 1-deoxyforskolin (DF) and forskolin to modulate cellular sensitivity to vinblastine (VBL) was examined in drug-sensitive parental KB-3-1 cells and a multidrug-resistant subline, KB-GRC1, derived by transfect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca5cab5b313917774eb2dc0f32668d2
https://doi.org/10.1038/bjc.1993.89

HIV-1 Tat neurotoxicity is prevented by matrix metalloproteinase inhibitors

Autor: J B, Johnston, K, Zhang, C, Silva, D R, Shalinsky, K, Conant, W, Ni, D, Corbett, V W, Yong, C, Power

Publikováno v: Annals of neurology. 49(2)

The release of potentially neurotoxic molecules by HIV-infected brain macrophages is accompanied by neuronal injury and death that results in the development of HIV-associated dementia (HAD). Among the potential neurotoxins implicated in the developm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::544c2edc8d2a53a7dc684be26af9c5b5
https://pubmed.ncbi.nlm.nih.gov/11220743

A novel retinoic acid receptor-selective retinoid, ALRT1550, has potent antitumor activity against human oral squamous carcinoma xenografts in nude mice

Autor: D R, Shalinsky, E D, Bischoff, W W, Lamph, L, Zhang, M F, Boehm, P J, Davies, A M, Nadzan, R A, Heyman

Publikováno v: Cancer research. 57(1)

We have identified a novel retinoid, ALRT1550, that potently and selectively activates retinoic acid receptors (RARs). ALRT1550 binds RARs with Kd values of approximately equal to 1-4 nM, and retinoid X receptors with low affinities (Kd approximately

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ff342854b43cd0ac4d667d089f4cc0f
https://pubmed.ncbi.nlm.nih.gov/8988059