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of 11
pro vyhledávání: '"D R, Rutledge"'
Publikováno v:
European Journal of Clinical Pharmacology. 40:603-607
There is little information about the factors which influence drug protein binding between species. We have therefore investigated the role of pH on the binding of gallopamil, a calcium channel antagonist known to exhibit pH-sensitive binding, among
Publikováno v:
Biochemistry and molecular biology international. 35(3)
Insertion/deletion (I/D) polymorphism of the angiotensin I converting enzyme (ACE) gene has been associated with ischemic heart disease and hypertension. The D allele reportedly correlates with myocardial infarction and it has been suggested that it
Publikováno v:
Biochemistry and molecular biology international. 34(6)
The purpose of the present study was to characterize three polymorphisms within the renin-angiotensin-aldosterone system in an African American population. A new mispairing primer polymerase chain reaction (PCR) was developed to identify two polymorp
Autor:
D R, Rutledge
Publikováno v:
Clinical pharmacy. 10(12)
Publikováno v:
Pharmaceutical research. 8(6)
The aim of this study was to determine in young, healthy men the relative contribution of pharmacodynamic factors inherent between two groups known to respond differently to hypertensive therapy. Black (n = 10) and white (n = 10) men received an isop
Publikováno v:
Bell System Technical Journal. 56:1923-1951
This paper describes the insertion method for installing WT4 waveguide. The rationale for the selection of the insertion method over competing installation techniques is provided, and the field installation tools and techniques developed to splice an
Autor:
D. R. Rutledge, D. A. Dixon
Publikováno v:
Journal of Engineering for Industry. 90:153-160
According to a granted U. S. Patent, it is contemplated that deep water pipelines be laid on the sea floor from an inclined derrick on a lay barge without the aid of a stinger. Means are presented in this paper for calculation of required tension and
Autor:
D. R. Rutledge, J. A. Pieper
Publikováno v:
European journal of clinical pharmacology. 33(4)
We have determined the extent and variability in the binding of gallopamil to human serum proteins. Binding was determined by equilibrium dialysis in healthy volunteer serum, human serum albumin (45 g.l-1), and alpha-1 acid glycoprotein (AAG) (600 mg
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 246(1)
Very little is known about the effects of hepatic enzyme induction with phenobarbital on the disposition of high clearance drugs in humans. Our study was undertaken to investigate the effect of phenobarbital on both alpha-1 acid glycoprotein concentr
Autor:
D R, Rutledge, M, Szlaczky
Publikováno v:
Pharmaceutical research. 5(9)