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NAD(P)H:quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis

Autor: D J, Long, R L, Waikel, X J, Wang, L, Perlaky, D R, Roop, A K, Jaiswal

Publikováno v: Cancer research. 60(21)

NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that catalyzes the metabolic detoxification of quinones and their derivatives. This protects cells against quinone-induced oxidative stress, cytotoxicity, and mutagenicity. C57BL6 NQO1-/- mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26f378a72225e58bcdf38867fdab2cad
https://pubmed.ncbi.nlm.nih.gov/11085502

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Cooperation between Ha-ras and fos or transforming growth factor alpha overcomes a paradoxic tumor-inhibitory effect of p53 loss in transgenic mouse epidermis

Autor: X J, Wang, D A, Greenhalgh, L A, Donehower, D R, Roop

Publikováno v: Molecular carcinogenesis. 29(2)

To investigate the role of loss of the p53 tumor suppressor gene in skin carcinogenesis, p53 knockout (p53(-/-)) mice were mated with transgenic mice coexpressing v-Ha-ras, v-fos, or human transforming growth factor alpha (TGFalpha) exclusively in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::abfeb07c9af35268b8381bb678d53611
https://pubmed.ncbi.nlm.nih.gov/11074603

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Transgenic coexpression of v-Ha-ras and transforming growth factor alpha increases epidermal hyperproliferation and tumorigenesis and predisposes to malignant conversion via endogenous c-Ha-ras activation

Autor: X J, Wang, D A, Greenhalgh, D R, Roop

Publikováno v: Molecular carcinogenesis. 27(3)

Previously, transgenic mice were generated that overexpressed v-Ha-ras or human transforming growth factor alpha (TGFalpha) exclusively in the epidermis, by means of a targeting vector based on the human keratin 1 gene (HK1). Both transgenics exhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5b546250a58449009b8b7e27ce9e8a2c
https://pubmed.ncbi.nlm.nih.gov/10708482

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Hot spot mutations in keratin 2e suggest a correlation between genotype and phenotype in patients with ichthyosis bullosa of Siemens

Autor: Y, Suga, M J, Arin, G, Scott, L A, Goldsmith, C M, Magro, L A, Baden, H P, Baden, D R, Roop

Publikováno v: Experimental dermatology. 9(1)

Ichthyosis bullosa of Siemens (IBS) is a rare disorder of cornification characterized by blister formation in the upper suprabasal layers of the epidermis. Molecular analysis of IBS has identified mutations in the keratin 2e (K2e) gene, which is loca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9bc4dc60aa1dde10b30e2c1b630babde
https://pubmed.ncbi.nlm.nih.gov/10688369

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12-O-tetradecanoylphorbol-13-acetate promotion of transgenic mouse epidermis coexpressing transforming growth factor-alpha and v-fos: acceleration of autonomous papilloma formation and malignant conversion via c-Ha-ras activation

Autor: X J, Wang, K M, Liefer, D A, Greenhalgh, D R, Roop

Publikováno v: Molecular carcinogenesis. 26(4)

To study oncoprotein cooperation in vivo, transgenic mice were established that coexpressed human transforming growth factor-alpha (TGFalpha) and v-fos exclusively in the epidermis by means of a human keratin 1 (HK1)-based vector. HK1.fos/alpha mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f667a95e68cc900bc98ed0d6b75a8e7f
https://pubmed.ncbi.nlm.nih.gov/10569807

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Analysis of centrosome abnormalities and angiogenesis in epidermal-targeted p53172H mutant and p53-knockout mice after chemical carcinogenesis: evidence for a gain of function

Autor: X J, Wang, D A, Greenhalgh, A, Jiang, D, He, L, Zhong, B R, Brinkley, D R, Roop

Publikováno v: Molecular carcinogenesis. 23(3)

We previously developed a transgenic mouse model that expresses in the epidermis a murine p53172R--H mutant (p53m) under the control of a human keratin-1-based vector (HK1.p53m). In contrast to mice with wild-type p53 and p53-knockout mice, HK1.p53m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c8808472ed21bace2e4e223049312a2d
https://pubmed.ncbi.nlm.nih.gov/9833779

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Prenatal diagnosis for keratin mutations to exclude transmission of epidermolytic hyperkeratosis

Autor: J A, Rothnagel, M T, Lin, M A, Longley, R A, Holder, P G, Hazen, M L, Levy, D R, Roop

Publikováno v: Prenatal diagnosis. 18(8)

Epidermolytic hyperkeratosis (bullous congenital ichthyosiform erythroderma) is an autosomal dominant skin disorder caused by mutations in keratins 1 and 10. We have used direct gene sequencing to ascertain the status of a 15 week fetus of parents wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::124e807bf7691acb7bb3e6a41f0afa32
https://pubmed.ncbi.nlm.nih.gov/9742571

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