Zobrazeno 1 - 10
of 31
pro vyhledávání: '"D R, Koop"'
Publikováno v:
Biochemical pharmacology. 62(7)
Administration of bacterial lipopolysaccharide (LPS) to laboratory animals and cultured macrophages induces tumor necrosis factor-alpha (TNF-alpha), a pro-inflammatory cytokine. Pretreatment with Ginkgo biloba extract (EGb 761) inhibited the in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3e268b7321bb94c2f294a124aadd627b
https://pubmed.ncbi.nlm.nih.gov/11543732
https://pubmed.ncbi.nlm.nih.gov/11543732
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(4)
A tetracycline (Tc)-controlled gene expression system that quantitatively controls gene expression in eukaryotic cells () was used to express cytochrome P-450 2E1 (CYP2E1) in HeLa cells in culture. The rabbit CYP2E1 cDNA was subcloned into the Tc-con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f58367916fc6c0ca7db2a4c0ed0bdae
https://pubmed.ncbi.nlm.nih.gov/10101151
https://pubmed.ncbi.nlm.nih.gov/10101151
Publikováno v:
Biochemistry. 38(11)
Previous modeling efforts have suggested that coumarin ligand binding to CYP2C9 is dictated by electrostatic and pi-stacking interactions with complementary amino acids of the protein. In this study, analysis of a combined CoMFA-homology model for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1585da90e4c72e95bee35ee56816aa92
https://pubmed.ncbi.nlm.nih.gov/10079071
https://pubmed.ncbi.nlm.nih.gov/10079071
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(6)
The regioselective epoxidation of oleic, linoleic, alpha-linolenic, and gamma-linolenic acid by cytochromes P4502CAA and P4502C2 was characterized. Epoxide metabolites for all fatty acids were resolved by normal phase HPLC and identified by gas chrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c61e288e0d516b9b7b5b5ecb799e32aa
https://pubmed.ncbi.nlm.nih.gov/8781783
https://pubmed.ncbi.nlm.nih.gov/8781783
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(3)
Cyclosporine is an immunosuppressant that undergoes extensive hepatic biotransformation to hydroxylated and demethylated metabolites. At present, the CYP3A gene family is thought to be the primary enzyme system responsible for cyclosporine metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1fd197316e9e59e6b53495ca6bb15e31
https://pubmed.ncbi.nlm.nih.gov/8667242
https://pubmed.ncbi.nlm.nih.gov/8667242
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 271(3)
In the present study, the regio- and stereoselective epoxidation of arachidonic acid by cytochromes P450 2C8 and 2C9, two members of the CYP2C gene subfamily expressed in human liver, was determined. Purified P450 isozymes, reconstituted with NADPH:P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::149b02066a8e08631212778717c0556a
https://pubmed.ncbi.nlm.nih.gov/7996455
https://pubmed.ncbi.nlm.nih.gov/7996455
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 269(3)
In the present study, we determined the stereoselective epoxidation of arachidonic acid by cytochrome P-450 (P-450) 2CAA and P-450 2C2, two arachidonic acid epoxygenases found in rabbit renal cortex, by chiral normal-phase high-performance liquid chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c1c48b0c384eb9b89f469727941721d4
https://pubmed.ncbi.nlm.nih.gov/8014857
https://pubmed.ncbi.nlm.nih.gov/8014857
Role of eicosanoids in vasopressin-induced calcium mobilization in A7r5 vascular smooth muscle cells
Publikováno v:
The American journal of physiology. 265(1 Pt 1)
The role of arachidonic acid (AA) and its metabolites in vasopressin (AVP)-induced calcium mobilization in A7r5 aortic smooth muscle cells was explored by intracellular calcium monitoring, [14C]AA labeling, and high-performance liquid chromatography
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1411994e3427e80538903f7d82be1214
https://pubmed.ncbi.nlm.nih.gov/8338143
https://pubmed.ncbi.nlm.nih.gov/8338143
Autor:
R M, Laethem, D R, Koop
Publikováno v:
Molecular pharmacology. 42(6)
Microsomes prepared from COS-1 cells transiently expressing rabbit cytochromes P450 2C1 and 2C2 catalyzed the metabolism of arachidonic acid to predominantly 11,12- and 14,15-epoxyeicosatrienoic acids (EETs) when microsomal epoxide hydrolase activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::434b801a2d9f12cfe20a030d734fefaf
https://pubmed.ncbi.nlm.nih.gov/1480136
https://pubmed.ncbi.nlm.nih.gov/1480136
Autor:
D R, Koop, C L, Laethem
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 20(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b26a2a8fa1d24115dee8cd649f81f43
https://pubmed.ncbi.nlm.nih.gov/1358586
https://pubmed.ncbi.nlm.nih.gov/1358586