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Design of Randomized Controlled Trials in the Treatment of Leg Ulcers: More Answers with Fewer Patients

Autor: D R Harper, C. V. Ruckley, E.A. Nelson, Robin J Prescott, J. J. Dale

Publikováno v: Phlebology: The Journal of Venous Disease. 13:107-112

Objective: To illustrate the benefit of the factorial design in randomized controlled trials of leg ulcers. Design: A 2 × 2 × 2 factorial design. Setting: Hospital leg ulcer clinics in Edinburgh and Falkirk. Patients: Adults with at least one unhea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c2d65beb35262c2b619dfc59eca1d31
https://doi.org/10.1177/026835559801300305

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Phage therapy of non-wound infections

Autor: Stephen T. Abedon, B. Burrowes, D. R. Harper, Paul Hyman

This chapter begins with an overview of the history of phage therapy as it pertains to non-wound infections, and then details more up-to-date experimental models (such as mice and dogs) and results. The following experimental infections are described

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5363ab0d80692f41a073ec66e7b23fba
https://doi.org/10.1079/9781845939847.0203

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Bacteriophages for the treatment of Pseudomonas aeruginosa infections

Autor: D R, Harper, M C, Enright

Publikováno v: Journal of applied microbiology. 111(1)

Bacteriophages were first identified in 1915 and were used as antimicrobial agents from 1919 onwards. Despite apparent successes and widespread application, early users did not understand the nature of these agents and their efficacy remained controv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f648ab660a61fdcafead3baf711b8e1c
https://pubmed.ncbi.nlm.nih.gov/21410851

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Determination of Viral Infectivity : HSV, VZV, and CMV

Autor: D R, Harper

Publikováno v: Methods in molecular medicine. 24

Compared to the wide range of antibiotics that are available, the number of antiviral drugs is limited. However, herpesviruses have always been a major target for antiviral drug design, and there are a wide range of drugs at various stages of develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f67c09652e120a4c493235cc4265a970
https://pubmed.ncbi.nlm.nih.gov/21331904

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Bacteriophage applications: where are we now?

Autor: A B, Monk, C D, Rees, P, Barrow, S, Hagens, D R, Harper

Publikováno v: Letters in applied microbiology. 51(4)

Bacteriophages are bacterial viruses and have been used for almost a century as antimicrobial agents. In the West, their use diminished when chemical antibiotics were introduced, but they remain a common therapeutic approach in parts of eastern Europ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::104208bb165438cfbeb4128aed752fc9
https://pubmed.ncbi.nlm.nih.gov/20796209

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Lothian and Forth Valley Leg Ulcer Healing Trial, Part 1: Elastic versus Non-Elastic Bandaging in the Treatment of Chronic Leg Ulceration

Autor: D. Brown, D R Harper, B. Gibson, C. V. Ruckley, J. J. Dale, Robin J Prescott, M. J. Callam

Publikováno v: Phlebology: The Journal of Venous Disease. 7:136-141

Objective: To determine whether elastic or non-elastic bandaging is more effective in healing chronic venous ulcers. Design: Randomized trial with factorial design and interaction analysis, enabling independent evaluation of both bandaging and dressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be5af7b447a6a292508815752c835da3
https://doi.org/10.1177/026835559200700402

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Lothian and Forth Valley Leg Ulcer Healing Trial, Part 2: Knitted Viscose Dressing versus a Hydrocellular Dressing in the Treatment of Chronic Leg Ulceration

Autor: Robin J Prescott, D. Brown, D R Harper, J. J. Dale, B. Gibson, C. V. Ruckley, M. J. Callam

Publikováno v: Phlebology: The Journal of Venous Disease. 7:142-145

Objective: To compare a new ‘advanced’ hydrocellular Polyurethane dressing (HPD) (Allevyn) with a traditional simple non-adherent knitted viscose dressing (KDV) (Tricotex) in the treatment of chronic venous leg ulcers. Design: A randomized trial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aac724e25c706abadd170a5d5dee3d76
https://doi.org/10.1177/026835559200700403

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Randomised, double blind placebo controlled trial of pentoxifylline in the treatment of venous leg ulcers

Autor: D R Harper, B. Gibson, J J Dale, E.A. Nelson, C. V. Ruckley, Robin J Prescott

Publikováno v: Dale, J J, Ruckley, C V, Harper, D R, Gibson, B, Nelson, EA & Prescott, R J 1999, ' Randomised, double blind placebo controlled trial of pentoxifylline in the treatment of venous leg ulcers ', British Medical Journal (BMJ), vol. 319, no. 7214, pp. 875-8 . https://doi.org/10.1136/bmj.319.7214.875

ObjectiveTo determine whether pentoxifylline 400 mg (Trental 400) taken orally three times daily, in addition to ambulatory compression bandages and dressings, improves the healing rate of pure venous ulcers.DesignRandomised, double blind placebo con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5df7505cf6681ff64cee9e0e029b36e
https://www.pure.ed.ac.uk/ws/files/16398512/Randomised_double_blind_placebo_controlled_trial_of_pentoxifylline_in_the_treatment_of_venous_leg_ulcers.pdf

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