Zobrazeno 1 - 10
of 32
pro vyhledávání: '"D R, Feller"'
Autor:
D. R. Feller, X. Zhang, G. Shams, J. E. De Los Angeles, Duane D. Miller, F.-L. Hsu, L. Lei, P. N. Patil, M.-Y. He, James T. Dalton
Publikováno v:
Journal of Medicinal Chemistry. 40:3014-3024
The synthesis and the biological evaluation of a new series of medetomidine analogs are reported. The substitution pattern at the phenyl ring of the tetralin analogs had a distinct influence on the alpha 2-adrenoceptor binding affinity. 4-Methylindan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213a754b2eb2d8488a33417a2f30495f
https://doi.org/10.1021/jm960642q
https://doi.org/10.1021/jm960642q
Autor:
M S, Jaradat, B, Wongsud, S, Phornchirasilp, S M, Rangwala, G, Shams, M, Sutton, K J, Romstedt, D J, Noonan, D R, Feller
Publikováno v:
Biochemical pharmacology. 62(12)
A series of nonsteroidal anti-inflammatory drugs (NSAIDs) [S(+)-naproxen, ibuprofen isomers, and indomethacin] were evaluated for their activation of peroxisome proliferator-activated receptor (PPAR) alpha and gamma isoforms in CV-1 cells co-transfec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd4957095a58c68952c8f12f82b85344
https://pubmed.ncbi.nlm.nih.gov/11755111
https://pubmed.ncbi.nlm.nih.gov/11755111
Autor:
A A, Konkar, V I, Nikulin, J, De Los Angeles, S S, Hong, R H, Fertel, D D, Miller, D R, Feller
Publikováno v:
Pharmacology. 62(1)
The biochemical activities of trimetoquinol (TMQ) analogs were evaluated at the human beta(1)- and beta(3)-adrenergic receptor (AR) subtypes expressed in Chinese hamster ovary cells. In radioligand binding assays, the 1-benzyl iodine-substituted anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8808040e647a1b46a8852542d54a1a36
https://pubmed.ncbi.nlm.nih.gov/11150922
https://pubmed.ncbi.nlm.nih.gov/11150922
Autor:
A A, Konkar, S S, Vansal, G, Shams, P F, Fraundorfer, W P, Zheng, V I, Nikulin, J, De Los Angeles, R H, Fertel, D D, Miller, D R, Feller
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 291(2)
The beta-adrenoceptor activities of trimetoquinol (TMQ) isomers and selected derivatives were evaluated on human beta-adrenoceptor subtypes expressed in Chinese hamster ovary cells. In cAMP accumulation assays, (-)-TMQ was 214-, 281-, and 776-fold mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e3922a05c86100bfc8cdb53520f59185
https://pubmed.ncbi.nlm.nih.gov/10525112
https://pubmed.ncbi.nlm.nih.gov/10525112
Publikováno v:
Chirality. 9(1)
Enantiomers of a series of substituted analogs of 2-(4-chlorophenoxy) -acetic acid (CPAA) were synthesized and used to examine the influence of steric and structural parameters on peroxisome proliferation. The effects of these compounds were studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8c02a4450da5759ef056f7d0040b0cea
https://pubmed.ncbi.nlm.nih.gov/9094202
https://pubmed.ncbi.nlm.nih.gov/9094202
Publikováno v:
Farmaco (Societa chimica italiana : 1989). 51(2)
The antilipidemic drug clofibric acid (CPIB) exhibits antiplatelet effects. In order to examine the role of enantioselectivity and hydrophobicity, the mono(desmethyl) enantiomers of 2-(4-chlorophenoxy)propanoic acid (CPPA), related butanoate homologs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4609f2df4ea584b7db38a393a8d424a
https://pubmed.ncbi.nlm.nih.gov/8857205
https://pubmed.ncbi.nlm.nih.gov/8857205
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 270(2)
Radioligand binding assays were used to characterize the interaction of a series of trimetoquinol [1-(3',4',5'-trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoqui nol ine; TMQ] analogs with beta adrenergic receptors (beta-AR). The results indica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::622328c9b5dbedce47096ec0ac0205d8
https://pubmed.ncbi.nlm.nih.gov/7915318
https://pubmed.ncbi.nlm.nih.gov/7915318
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 267(3)
Trimetoquinol (TMQ), a nonprostanoid compound, inhibits thromboxane A2 agonist-induced responses in platelets and vascular smooth muscle. Sixteen TMQ analogs were used to examine the stereochemical requirements of the interaction with thromboxane A2/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b425d1298bae09dbc0f9c4b50418b236
https://pubmed.ncbi.nlm.nih.gov/7903383
https://pubmed.ncbi.nlm.nih.gov/7903383
Publikováno v:
Journal of neural transmission. Supplementum. 34
Based on the pharmacological activity of chiral imidazolines the steric requirements for the activation of the alpha-adrenoceptor are provided. Importantly, the sequence of interaction of the critical groups of the asymmetric carbon of imidazolines a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::51401a971621faf3d36501773e274a4a
https://pubmed.ncbi.nlm.nih.gov/1667871
https://pubmed.ncbi.nlm.nih.gov/1667871
Publikováno v:
Biochemical pharmacology. 40(6)
We have examined, relative to clofibric acid (CPIB), the effects of a chemical series of phenoxyacetic acids and of two asymmetric CPIB analogues, the R(+)- and S(-)-enantiomers of 2-(4-chlorophenoxy)propionic acid (4-CPPA) and 2-(4-chlorophenoxy)but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::884970d7b249162be2d42cc0d8b01055
https://pubmed.ncbi.nlm.nih.gov/2403380
https://pubmed.ncbi.nlm.nih.gov/2403380