Zobrazeno 1 - 10
of 40
pro vyhledávání: '"D R, Crapper McLachlan"'
Autor:
M.P. Montesi, Ranjan Duara, T. Tsuda, Jonathan L. Haines, Amalia C. Bruni, Rudolph E. Tanzi, N. Alexandrova, James F. Gusella, J. M. Cantu, Fabio Macciardi, Allen D. Roses, Walter J. Lukiw, Lindsay A. Farrer, Ekaterina Rogaeva, James L. Kennedy, Sandro Sorbi, M. Mortilla, Karen Schlumpf, L. Nee, Evgeny I. Rogaev, L. Bergamini, Daniel A. Pollen, Innocenzo Rainero, P. St. George-Hyslop, R. Polinsky, Luigi Amaducci, Yan Liang, J. F. Foncin, Margaret A. Pericak-Vance, D. R. Crapper McLachlan, G. Vaula, Lorenzo Pinessi
Publikováno v:
Nature Genetics. 2:330-334
Familial Alzheimer's disease (FAD) has been shown to be genetically heterogeneous, with a very small proportion of early onset pedigrees being associated with mutations in the amyloid precursor protein (APP) gene on chromosome 21, and some late onset
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbad04d63d78611679fedf076a5228c
https://doi.org/10.1038/ng1292-330
https://doi.org/10.1038/ng1292-330
Autor:
L. Wong, D. R. Crapper McLachlan, Catherine Bergeron, P. Handley, Larry K.K. Yoong, M. Kung Sutherland, Martin J. Somerville
Publikováno v:
Neurobiology of Aging. 13:301-312
A history of thyroid dysfunction has been cited as a possible risk factor for Alzheimer's disease (AD). Neurologic symptoms displayed by hypothyroid patients resemble, in part, those manifested by Alzheimer patients. To determine if a relationship ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4bfd93ff95789fd635f3d11987c6546
https://doi.org/10.1016/0197-4580(92)90043-w
https://doi.org/10.1016/0197-4580(92)90043-w
Publikováno v:
The Lancet. 336:1162-1165
'McIntyre Powder' (finely ground aluminium and aluminium oxide) was used as a prophylactic agent against silicotic lung disease between 1944 and 1979 in mines in northern Ontario. To find out whether the practice produced neurotoxic effects a morbidi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0798a48b3301c70ed6057a450c12c23a
https://doi.org/10.1016/0140-6736(90)92775-d
https://doi.org/10.1016/0140-6736(90)92775-d
Publikováno v:
Environmental Geochemistry and Health. 12:103-114
The etiology of some, if not all, cases of Alzheimer's disease is linked to a mutation in the proximal portion of the long arm of chromosome 21∶21q11.2 → 21q22.2. While the functional consequences of the mutation are unknown, we speculate that on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1ac55895606d819b79aba57a3b92af2
https://doi.org/10.1007/bf01734059
https://doi.org/10.1007/bf01734059
Autor:
MichaelA Weiner, W. Kalow, Trond Peder Flaten, M.Y. Bell, D. R. Crapper McLachlan, T.P.A. Kruck, Ralph M. Garruto, David F. Andrews, Joel Richard Goldstone, W.L. Smith, A. J. Dalton, Donald R. Holleman, Peter Davies
Publikováno v:
The Lancet. 338:324-326
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44f41d70b0910ec1c91347ee3d72c249
https://doi.org/10.1016/0140-6736(91)90472-2
https://doi.org/10.1016/0140-6736(91)90472-2
Autor:
Ekaterina Rogaeva, Yan Liang, David A. Drachman, Evgeny I. Rogaev, T. Tsuda, Ranjan Duara, Jonathan L. Haines, Matthew L. Freedman, Daniel A. Pollen, P. St. George-Hyslop, D. R. Crapper McLachlan, Ramon Lopez
Publikováno v:
Annals of neurology. 36(1)
Allele frequencies for polymorphisms in the apolipoprotein E and the apolipoprotein CII genes were determined in subjects of Ashkenazi Jewish origin with late-onset Alzheimer's disease and in unaffected control subjects from the same ethnic group. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e82d04bbe1750ffdb0b0973319e672
https://pubmed.ncbi.nlm.nih.gov/8024269
https://pubmed.ncbi.nlm.nih.gov/8024269
Autor:
Maire E. Percy, Lorenzo Pinessi, D. R. Crapper McLachlan, Paul E. Fraser, W.G. Tatton, G. Vignocchi, Innocenzo Rainero, T. Tsuda, S. Munthasser, L Bergamini, Giovanna Vaula, P. St. George-Hyslop
Mutations in the Cu, Zn superoxide dismutase ( SOD1 ) gene have been reported in some pedigrees with Familial Amyotrophic Lateral Sclerosis (FALS). We have investigated the functional and structural effects of a Gly→Ser mutation at codon 41 of SOD1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886215652236d3911b4e3111431b3135
http://hdl.handle.net/2318/34013
http://hdl.handle.net/2318/34013
Publikováno v:
Neurology. 77:1083-1083
Clinical and neuropathologic evidence points to the development of Alzheimer's disease (AD) in seven Down's syndrome patients above age 40. Dementia was observed in these patients over periods of 2.5 to 9.2 years. The first clinical sign of AD, visua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562250ae0af5e93d6eaf51d9099080dc
https://doi.org/10.1212/01.wnl.0000405415.07883.36
https://doi.org/10.1212/01.wnl.0000405415.07883.36
Autor:
D. R. Crapper McLachlan, Yan Liang, T. Tsuda, Ekaterina Rogaeva, Walter J. Lukiw, Evgeny I. Rogaev, P. H. Saint George-Hyslop, G. Galway, J. Smith, N. Alexandrova, Q. Fong, L. Wong, L. Jiang
Publikováno v:
Neuroscience letters. 152(1-2)
Recent genetic linkage studies have implicated a gene on chromosome 14 in the pathogenesis of FAD. The identify of this gene remains unknown but it has been speculated that it may be involved in the cellular processing of the amyloid precursor protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f55614f6cbaf40d8a1ebb8099fdca1
https://pubmed.ncbi.nlm.nih.gov/8515885
https://pubmed.ncbi.nlm.nih.gov/8515885
Publikováno v:
Neurochemical research. 17(6)
BC200 RNA is a polyadenylated 200 nucleotide primate brain-specific transcript with 80% homology to the left monomer of the human Alu family of repetitive elements. Whether this transcription product contributes anything to normal brain gene function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a206409adcfaecd6e3226d1b383c99ff
https://pubmed.ncbi.nlm.nih.gov/1603265
https://pubmed.ncbi.nlm.nih.gov/1603265