Zobrazeno 1 - 10
of 329
pro vyhledávání: '"D Peter, Tieleman"'
Autor:
Alessia Golluscio, Jodene Eldstrom, Jessica J Jowais, Marta Elena Perez, Kevin Peter Cunningham, Alicia De La Cruz, Xiaoan Wu, Valentina Corradi, D Peter Tieleman, David Fedida, H Peter Larsson
Publikováno v:
eLife, Vol 13 (2024)
In cardiomyocytes, the KCNQ1/KCNE1 channel complex mediates the slow delayed-rectifier current (IKs), pivotal during the repolarization phase of the ventricular action potential. Mutations in IKs cause long QT syndrome (LQTS), a syndrome with a prolo
Externí odkaz:
https://doaj.org/article/3b70b86ed7a5417386c6095c41baafa2
Autor:
Sultan Mayar, Mariia Borbuliak, Andreas Zoumpoulakis, Tahar Bouceba, Madeleine M. Labonté, Ameneh Ahrari, Niveny Sinniah, Mina Memarpoor-Yazdi, Catherine Vénien-Bryan, D. Peter Tieleman, Nazzareno D’Avanzo
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The inward rectifier potassium channel Kir2.1 (KCNJ2) is an important regulator of resting membrane potential in both excitable and non-excitable cells. The functions of Kir2.1 channels are dependent on their lipid environment, including the availabi
Externí odkaz:
https://doaj.org/article/e4c24897ce8d40efb4d3405885a908fb
Autor:
Beibei Wang, D. Peter Tieleman
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-9 (2023)
Electrospray ionization (ESI) mass spectrometry is invaluable for studying complex biological systems, and although lipid nanodiscs are a powerful tool for the study of membrane proteins, a lack of clear understanding of the ESI mechanism presents a
Externí odkaz:
https://doaj.org/article/b815c72e74e24d548a1479edece8cf6c
Autor:
Hristina R. Zhekova, Jiansen Jiang, Weiguang Wang, Kirill Tsirulnikov, Gülru Kayık, Hanif Muhammad Khan, Rustam Azimov, Natalia Abuladze, Liyo Kao, Debbie Newman, Sergei Yu. Noskov, D. Peter Tieleman, Z. Hong Zhou, Alexander Pushkin, Ira Kurtz
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
CryoEM structures and computational modeling of bovine anion exchanger 1 in both inward and outward facing conformations reveal an elevator-like mechanism of ion transport by a solute carrier ion transport family 4 member.
Externí odkaz:
https://doaj.org/article/a87cecb4c5cf4b3eb5b6a1ab6c4bead0
Autor:
Briana M Bohannon, Jessica J Jowais, Leif Nyberg, Vanessa Olivier-Meo, Valentina Corradi, D Peter Tieleman, Sara I Liin, H Peter Larsson
Publikováno v:
eLife, Vol 12 (2023)
Voltage-gated potassium (KV) channels are important regulators of cellular excitability and control action potential repolarization in the heart and brain. KV channel mutations lead to disordered cellular excitability. Loss-of-function mutations, for
Externí odkaz:
https://doaj.org/article/7551a63ea06f42c399ecf18db23a441f
Autor:
Irene Hiniesto-Iñigo, Laura M. Castro-Gonzalez, Valentina Corradi, Mark A. Skarsfeldt, Samira Yazdi, Siri Lundholm, Johan Nikesjö, Sergei Yu Noskov, Bo Hjorth Bentzen, D. Peter Tieleman, Sara I. Liin
Publikováno v:
EBioMedicine, Vol 89, Iss , Pp 104459- (2023)
Summary: Background: Genotype-positive patients who suffer from the cardiac channelopathy Long QT Syndrome (LQTS) may display a spectrum of clinical phenotypes, with often unknown causes. Therefore, there is a need to identify factors influencing dis
Externí odkaz:
https://doaj.org/article/68cc94b6c4f549b4b603e7aeba51442e
Autor:
Williams E. Miranda, Jiqing Guo, Haydee Mesa-Galloso, Valentina Corradi, James P. Lees-Miller, D. Peter Tieleman, Henry J. Duff, Sergei Yu. Noskov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The lipid regulation of mammalian ion channel function has emerged as a fundamental mechanism in the control of electrical signalling and transport specificity. Here, the authors combine molecular dynamics simulations, mutagenesis, and electrophysiol
Externí odkaz:
https://doaj.org/article/f5eb9a98c2804d9bb7a7f7b17805b054
Autor:
Meruyert Kudaibergenova, Jiqing Guo, Hanif M. Khan, James Lees-Miller, Mahdi Mousaei, Williams Miranda, Van A. Ngo, Sergei Yu Noskov, D. Peter Tieleman, Henry J. Duff
Publikováno v:
Biophysical Journal. 121:4585-4599
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::895d852b87ba1d2943131dcfe5ebfb59
https://doi.org/10.1016/j.bpj.2022.10.032
https://doi.org/10.1016/j.bpj.2022.10.032
Autor:
Valentina Corradi, Eduardo Mendez-Villuendas, Helgi I. Ingólfsson, Ruo-Xu Gu, Iwona Siuda, Manuel N. Melo, Anastassiia Moussatova, Lucien J. DeGagné, Besian I. Sejdiu, Gurpreet Singh, Tsjerk A. Wassenaar, Karelia Delgado Magnero, Siewert J. Marrink, D. Peter Tieleman
Publikováno v:
ACS Central Science, Vol 4, Iss 6, Pp 709-717 (2018)
Externí odkaz:
https://doaj.org/article/db97d572cfee429aa2cca91ede5193a4
Autor:
Flora Szeri, Valentina Corradi, Fatemeh Niaziorimi, Sylvia Donnelly, Gwenaëlle Conseil, Susan P. C. Cole, D. Peter Tieleman, Koen van de Wetering
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 6910 (2021)
Inactivating mutations in ABCC6 underlie the rare hereditary mineralization disorder pseudoxanthoma elasticum. ABCC6 is an ATP-binding cassette (ABC) integral membrane protein that mediates the release of ATP from hepatocytes into the bloodstream. Th
Externí odkaz:
https://doaj.org/article/c95eb2efa81f43438ed8c3196f15c572