Zobrazeno 1 - 10
of 149
pro vyhledávání: '"D Papadopoulo"'
Autor:
Nicholas J. Finnie, J.P. de Villartay, Marina Cavazzana-Calvo, N Nicolas, Alain Fischer, F Le Deist, D Papadopoulo, Stephen P. Jackson
Publikováno v:
European Journal of Immunology. 26:1118-1122
The initial step of the V(D)J recombination occurs through the generation of a DNA double-strand break (dsb). Defects in the DNA-dependent protein kinase complex (DNA-PK) result in an inability to perform either V(D)J recombination or any dsb repair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0617d1fe9d8d39a5bc150a3b35fbd175
https://doi.org/10.1002/eji.1830260524
https://doi.org/10.1002/eji.1830260524
Autor:
Marina Cavazzana-Calvo, G de Saint Basile, J P de Villartay, Alain Fischer, D Papadopoulo, F Le Deist
Publikováno v:
Journal of Clinical Investigation. 91:1214-1218
We studied the radiosensitivity of granulocyte macrophage colony-forming units (GM-CFU) in patients with a severe combined immunodeficiency (SCID). Three patients lacking both mature T and B cells showed a twofold higher GM-CFU radiosensitivity calcu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3415026a67584312575a4954691bc499
https://doi.org/10.1172/jci116282
https://doi.org/10.1172/jci116282
Publikováno v:
Journal of molecular biology. 281(5)
The hallmark of Fanconi anemia (FA), a rare inherited cancer prone disorder, is a high level of chromosome breakage, spontaneous and induced by cross-linking agents. The increased genomic instability of FA is reflected at the gene level by an overpro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7b4299af0b07b89d561e9803284e815e
https://pubmed.ncbi.nlm.nih.gov/9719637
https://pubmed.ncbi.nlm.nih.gov/9719637
Publikováno v:
Radiation research. 133(1)
Survival and HPRT- mutant frequency were measured in human lymphoblastoid cells preexposed or not to a low dose of 0.02 Gy gamma rays and then treated with a high dose of 4.0 Gy. When compared to the high dose alone, the low-dose preexposure induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::15a92db6658b2322c3c0908bd8952d91
https://pubmed.ncbi.nlm.nih.gov/8434119
https://pubmed.ncbi.nlm.nih.gov/8434119
Autor:
Ethel Moustacchi, D. Papadopoulo
Publikováno v:
Mutation research. 245(4)
The photobiological effects induced by the monofuctional 7-methylpyrido[3,4- c ]psoralen (MePyPs) in comparison to the bifunctional furocoumarin 8-methoxypsoralen (8-MOP) have been studied in a human lymphoblast cell line TK6. We report that, in huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701082f2a27e02a27c7ccdf3278c7e36
https://pubmed.ncbi.nlm.nih.gov/2176273
https://pubmed.ncbi.nlm.nih.gov/2176273
Fanconi anemia (FA) is an inherited human disorder associated with a predisposition to cancer and characterized by anomalies in the processing of DNA cross-links and certain monoadducts. We reported previously that the frequency of psoralen-photoindu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da94f6bc17c6b0573a8bf04c48f2cccb
https://europepmc.org/articles/PMC54960/
https://europepmc.org/articles/PMC54960/
Publikováno v:
Cancer research. 50(11)
The induction of mutants at the hypoxanthine-guanine phosphoribosyltransferase and Na+/K+ ATPase loci by photoaddition of two bifunctional psoralens was compared in normal and in Fanconi's anemia lymphoblasts from the genetic complementation group A.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::94935890c1a52df28098a9cb6672dad0
https://pubmed.ncbi.nlm.nih.gov/2159378
https://pubmed.ncbi.nlm.nih.gov/2159378
Publikováno v:
Nouvelle revue francaise d'hematologie. 32(6)
Several features of Fanconi's anemia (FA) are reported: relative inefficiency in the processing of DNA cross-links and monoadducts, hypomutability at the two loci analysed, complementation of the cytogenetic defect by cocultivation with mouse cells a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::109eb60fe63c3e186df0cfdc49ed452e
https://pubmed.ncbi.nlm.nih.gov/2101869
https://pubmed.ncbi.nlm.nih.gov/2101869
Publikováno v:
Radiation Research. 133:94
Survival and $HPRT^{-}$ mutant frequency were measured in human lymphoblastoid cells preexposed or not to a low dose of 0.02 Gy γ rays and then treated with a high dose of 4.0 Gy. When compared to the high dose alone, the low-dose preexposure induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02e09d33851ece98109338d6863e9418
https://doi.org/10.2307/3578262
https://doi.org/10.2307/3578262
Publikováno v:
British Journal of Cancer. 36:65-71
We have maintained in culture, for a prolonged period, untreated hamster cells from whole embryo, foetal brain and lung from newborn animals. Among the 7 lines studied we observed only one spontaneous transformation during the first year of culture.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf05db54caec95b61ff2811c4ed5e25b
https://doi.org/10.1038/bjc.1977.155
https://doi.org/10.1038/bjc.1977.155