Zobrazeno 1 - 10
of 48
pro vyhledávání: '"D Pade"'
Publikováno v:
Current Opinion in Toxicology. :98-105
The dog is an important species used in preclinical studies in support of human drug product development. Likewise, because of the many active pharmaceutical ingredients with therapeutic relevance to both humans and dogs, extrapolation can also occur
Autor:
Marilyn N. Martinez, Raafat Fahmy, Mansoor A. Khan, Xavier Pepin, Jonathan P. Mochel, Sara Carlert, Patrick J. Sinko, Masoud Jamei, Viera Lukacova, D Pade, Murat Cirit, Sid Bhoopathy, Konstantin Tsinman, David C. Sperry, Talia Flanagan, Maria Vertzoni, Christos Reppas, Ben Forbes
Publikováno v:
Dissolution Technologies. 26:38-66
Publikováno v:
The AAPS Journal. 23
This review is a summary of factors affecting the drug pharmacokinetics (PK) of dogs versus humans. Identifying these interspecies differences can facilitate canine-human PK extrapolations while providing mechanistic insights into species-specific dr
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 141
Oral bioavailability of poorly water soluble (BCS II) drugs like danazol can be minimal without the necessary formulation strategies. Availability of in vitro physicochemical and in vivo pharmacokinetic studies can be valuable when designing these st
Publikováno v:
Biopharmaceuticsdrug disposition. 38(2)
A major component of physiologically based pharmacokinetic (PBPK) models is the prediction of the rate and extent of absorption of orally dosed drugs for which knowledge of effective passive intestinal permeability (P
Autor:
Robert A. Newman, Xinyu Wang, Jihai Pang, Sean M. Kerwin, Phillip D. Bowman, D Pade, Salomon A Stavchansky, Jacqueline A. Maffucci
Publikováno v:
Biopharmaceutics & Drug Disposition. 30:221-228
The pharmacokinetic profiles of caffeic acid phenethyl ester (CAPE) and its catechol-ring fluorinated derivative (FCAPE) were determined in rats after intravenous administration of 5, 10 or 20 mg/kg for CAPE and 20 mg/kg for FCAPE, respectively. The
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Autor:
B. M. Szabo, S. S. Datta, J. L. Wile, Jan Toke, W. U. Schröder, J.R. Huizenga, B. M. Quednau, S. P. Baldwin, D. Pade, Romualdo deSouza
Publikováno v:
Physical Review C. 47:2135-2145
Neutrons from the fusion reactions of 120--150 MeV [sup 28]Si with [sup 118]Sn and [sup 124]Sn target nuclei have been measured in coincidence with evaporation residues, in two series of complementary experiments using either a 4[pi] neutron multipli
Publikováno v:
Physical Review C. 43:1288-1297
Neutron folds in two high-efficiency neutron multiplicity meters (NMM) were measured in coincidence with projectilelike fragments from the $^{165}\mathrm{Ho}$${+}^{56}$Fe reaction at a low bombarding energy of ${\mathit{E}}_{\mathrm{lab}}$=7.2 MeV/nu
Autor:
D Pade, Salomon A Stavchansky
Publikováno v:
Molecular pharmaceutics. 5(4)
Bioavailability data for herbal supplements in humans is not readily available or is difficult to obtain, because of the complexity of the composition and the diversity of the constituents. Potency of an herbal extract is due to the synergistic inter