Zobrazeno 1 - 10
of 155
pro vyhledávání: '"D P O'Donoghue"'
Autor:
F. Sclafani, P. R. O'Connell, Robert Geraghty, Ishwarya Balasubramanian, David Gibbons, Helen Mohan, D. P. O’Donoghue, Rory Kennelly, S. T. Martin, Éanna J Ryan, John Hyland, Ray McDermott, Elizabeth J. Ryan, D Fennelly, Des C. Winter, Kieran Sheahan
Publikováno v:
European Journal of Surgical Oncology (EJSO). 42:1680-1686
Up to 15% of colorectal cancers exhibit microsatellite instability (MSI), where errors in replication go unchecked due to defects in the mismatch repair system. This study aimed to determine survival in a large single-centre series of 1250 consecutiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d721531a79e895a57bb1215d005d1c
https://doi.org/10.1016/j.ejso.2016.05.013
https://doi.org/10.1016/j.ejso.2016.05.013
Autor:
Andrew Green, Denise Keegan, James M. O’Riordan, S. J. Payne, L. A. Hawkes, D. P. O’Donoghue, Des C. Winter, Kieran Sheahan
Publikováno v:
Colorectal Disease. 12:570-573
The conditions Juvenile Polyposis Syndrome (JPS) and Hereditary Mixed Polyposis Syndrome (HMPS) are associated with an increased risk of colorectal carcinoma. The genetic mechanisms which explain these conditions have until recently been poorly under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e28212dc9560d5b78950e6ef46588066
https://doi.org/10.1111/j.1463-1318.2009.01931.x
https://doi.org/10.1111/j.1463-1318.2009.01931.x
Publikováno v:
British Journal of Pharmacology. 155:558-566
Background and purpose: Kinins are acknowledged as important regulators of intestinal function during inflammation; however, their effects on human intestinal ion transport have not been reported. Here, we used muscle-stripped human colonic tissue an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df30734b68f1d8c9fbcde41f0da084eb
https://doi.org/10.1038/bjp.2008.288
https://doi.org/10.1038/bjp.2008.288
Publikováno v:
Colorectal Disease. 7:286-291
Objective Enterovesical fistulae are a recognized complication of a variety of inflammatory and neoplastic conditions. Despite advances in imaging and treatment the diagnosis may be delayed and the management remains diverse. We describe our experien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098d09592b919cecbf65c3260e3d10c7
https://doi.org/10.1111/j.1463-1318.2005.00786.x
https://doi.org/10.1111/j.1463-1318.2005.00786.x
Publikováno v:
European Journal of Cancer. 40:1610-1616
Cathepsin B and Cathepsin L are cysteine proteases important in the process of invasion and metastasis. The aim of our study was to assay antigen and activity levels of these enzymes and to correlate these with established clinical and pathological p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1720e586bc36013364db365f8d1480
https://doi.org/10.1016/j.ejca.2004.03.011
https://doi.org/10.1016/j.ejca.2004.03.011
Autor:
P. R. O'Connell, D. P. O’Donoghue, Kieran Sheahan, John Calvin Coffey, Desmond C. Winter, Grainne Lennon, R.P. Ross, John Hyland, Glen A. Doherty, Aoife Maguire, Hugh Mulcahy, Aine Balfe, Orla O'Sullivan, Fergus Shanahan, Aonghus Lavelle, Neil G. Docherty, Paul D. Cotter
Publikováno v:
Gut
Objectives The relevance of spatial composition in the microbial changes associated with UC is unclear. We coupled luminal brush samples, mucosal biopsies and laser capture microdissection with deep sequencing of the gut microbiota to develop an inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a258c9772d1fd93b5f9b359f5b501cb
https://pubmed.ncbi.nlm.nih.gov/25596182
https://pubmed.ncbi.nlm.nih.gov/25596182
Autor:
Kieran Sheahan, Derek Moriarty, P. A. McCormick, Alan W. Baird, Geraldine McCormack, D. P. O’Donoghue
Publikováno v:
Scopus-Elsevier
Objective and design: This study aimed to determine if mucosal expression of the chemokines IL-8, RANTES and MCP-1 and the pro-inflammatory cytokines TNFα and IL-6 are elevated in patients with inflammatory bowel disease.¶Materials and subjects: In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::845223d384d123b6b5b2ebd112e162f0
https://doi.org/10.1007/pl00000223
https://doi.org/10.1007/pl00000223
Publikováno v:
British Journal of Pharmacology. 133:1346-1354
This in vitro study was designed to determine the potential use of the NK1 antagonist, SR140333 as an anti-diarrhoeal treatment for food allergy or inflammatory bowel disease. The effect of various immune and neuronal stimuli on human colonic substan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66fa934b421a9afb88f4bdddc1b4b6bc
https://doi.org/10.1038/sj.bjp.0704194
https://doi.org/10.1038/sj.bjp.0704194
Publikováno v:
Alimentary Pharmacology & Therapeutics. 15:665-668
Background: The efficacy of cyclosporin in the management of ulcerative colitis is recognized. Not all patients respond to this treatment. Existing clinical and laboratory parameters are of little use in identifying those most likely to respond. Aims
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e1e97a22bed6d1dc34ebece687291ee
https://doi.org/10.1046/j.1365-2036.2001.00977.x
https://doi.org/10.1046/j.1365-2036.2001.00977.x
Autor:
R. G. P. Watson, B. M. Bhatt, K. G. Porter, C. Doherty, C. McCaughey, T. S. Wilson, D. F. Hughes, J. D. Biggart, C. L. Little, G. C. Corbett-Feeney, M. P. G. Little, C. F. McCarthy, G. Kavanagh, S. Kee, J. McNulty, J. F. Fielding, J. Huang, C. Smyth, J. P. Arbuthnott, N. P. Kennedy, A. Chua, P. W. N. Keeling, J. Lappin, P. Gillen, P. Burke, J. Hyland, A. D. Hill, D. P. O’Donoghue, S. J. McGrath, K. D. Buchanan, C. F. Johnston, K. Barry, D. J. Waldron, P. G. Horgan, M. McGuire, H. F. Given, K. B. Bamford, J. S. A. Collins, T. S. Wilson., S. Patchett, T. O’Riordan, E. Leen, C. Keane, C. O’Morain, D. G. Gilroy, E. J. Mackle, R. A. J. Spence, G. W. Johnson, K. R. O’Sullivan, P. M. Mathias, A. Tobin, C. A. O’Morain, M. E. Carson, F. M. Stevens, M. Bourke, M. Kearns, F. Gannon, D. P. O’Donoghue., S. Ah-Kion, M. O’Driscoll, E. Lee, C. Bolger, P. Kelleher, M. McDonald, P. J. Byrne, T. Gorey, T. P. Hennessy, E. B. Casey, M. MacMahon, B. Hogan, M. O’Sullivan, M. G. Courtney, J. S. Doyle, D. Hamilton, T. Dinan, Fiona M. Stevens, D. Nugent, P. F. Fottrell, J. L. Templeton, M. Madden, M. Elliot, A. Ah Kion, L. N. Yatham, S. Barry, T. Boyle, D. J. Veale, O. Fitzgerald, G. S. A. McDonald, S. R. McCann, D. G. Weir, H. Saleh, D. Waldron
Publikováno v:
Irish Journal of Medical Science. 159:219-225
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::743d72e98ae5756251b925d112bc50b3
https://doi.org/10.1007/bf02937271
https://doi.org/10.1007/bf02937271