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pro vyhledávání: '"D P, Vik"'
Publikováno v:
Scandinavian Journal of Immunology. 49:487-494
Factor H is a regulatory protein of the alternative pathway of complement activation. The liver is the major site of synthesis. We have used the Hep3b human liver cell line as a model for examining its regulation by interferon-gamma (IFN-gamma). The
Autor:
T A Funkhouser, D. P. Vik
Publikováno v:
Scandinavian Journal of Immunology. 49:21-28
Complement receptor type 1 (CR1) is expressed principally on erythrocytes, monocytes, neutrophils and B cells, where it acts as a negative regulator of the complement cascade and as a clearance mechanism for immune complexes. As CR1 expression occurs
Autor:
T A Funkhouser, D. P. Vik
Publikováno v:
Scandinavian Journal of Immunology. 49:29-37
Binding to erythrocyte complement receptor type 1 (CR1) clears immune complexes from blood and tissues, preventing complement-mediated pathological inflammation in disease. Previous work has demonstrated that Ara-C, a cytosine analogue, induces an 11
Publikováno v:
The Journal of Immunology. 151:6214-6224
The genes for human complement receptor type 1 (CR1) F and S alleles have been cloned and span a region of 133-160 kb on chromosome 1. The F allele was found to comprise 39 exons and the S allele contains an additional 8 exons. The leader sequence an
Publikováno v:
Journal of Biological Chemistry. 267:20400-20406
C4b-binding protein (C4BP) is involved in the fluid-phase regulation of the classical pathway of complement. A murine genomic library was screened, and five clones were selected that covered the remaining four exons in the 5'-region of the C4BP gene.
Autor:
D. P. Vik, S. A. Williams
Publikováno v:
Scandinavian journal of immunology. 45(1)
The promoter region of the human factor H gene was cloned and a 3 kb Eco RI fragment was sequenced. Primer extension and S1 nuclease analysis were used to determine the transcription start site, which was found to be 10-11 nucleotides upstream of the
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 151(11)
The genes for human complement receptor type 1 (CR1) F and S alleles have been cloned and span a region of 133-160 kb on chromosome 1. The F allele was found to comprise 39 exons and the S allele contains an additional 8 exons. The leader sequence an
Publikováno v:
The Journal of biological chemistry. 267(28)
C4b-binding protein (C4BP) is involved in the fluid-phase regulation of the classical pathway of complement. A murine genomic library was screened, and five clones were selected that covered the remaining four exons in the 5'-region of the C4BP gene.
Publikováno v:
The Journal of biological chemistry. 266(28)
Human C5 cDNA fragments were used to identify five overlapping cosmid clones that spanned the entire C5 gene. Partial sequencing and Southern analysis of the clones were performed to identify intron/exon boundaries and to map intron size. The human C
Mapping of a retinoic acid-responsive element in the promoter region of the complement factor H gene
Publikováno v:
The Journal of biological chemistry. 265(33)
Retinoic acid receptors are members of the steroid/thyroid hormone receptor superfamily. Pursuant to the discovery that dexamethasone increases complement factor H expression, we examined the effects of retinoic acid on this gene. Both H mRNA and pro