Zobrazeno 1 - 10
of 26
pro vyhledávání: '"D P, Suttle"'
Publikováno v:
Oncogene. 18:7149-7160
Topoisomerase II alpha (topo II alpha) is a major target of antitumor treatments. In an effort to determine why this protein might be a better target in tumor cells than in normal cells, we attempted to determine if the altered proliferative signalin
Autor:
Lin T, D. P. Suttle
Publikováno v:
Somatic Cell and Molecular Genetics. 21:161-175
Segments of the human UMP synthase cDNA coding for the orotate phosphoribosyl transferase (OPRT) and orotidylate decarboxylase (ODC) domains of the bifunctional protein UMP synthase were produced by polymerase chain reaction techniques and cloned int
Autor:
D. P. Suttle, Carolyn R. Zelnick, Igor B. Roninson, William T. Beck, Rama Thimmapaya, Alexander R. Kazarov, Andrei V. Gudkov
Publikováno v:
Proceedings of the National Academy of Sciences. 90:3231-3235
Many cytotoxic anticancer drugs act at topoisomerase II (topo II) by stabilizing cleavable complexes with DNA formed by this enzyme. Several cell lines, selected for resistance to topo II-interactive drugs, show decreased expression or activity of to
Autor:
Ti Lin, D. P. Suttle
Publikováno v:
Somatic Cell and Molecular Genetics. 19:193-202
Orotate phosphoribosyltransferase (OPRT) and orotidine-5'-monophosphate decarboxylase (ODC), which catalyze the last two steps in de novo UMP biosynthesis, are two distinct monofunctional proteins in bacteria and lower eukaryotes. In mammals, OPRT an
Publikováno v:
Proceedings of the National Academy of Sciences. 88:7654-7658
Nuclear extracts from teniposide (VM-26)-resistant sublines of the human leukemic cell line CCRF-CEM have decreased levels of DNA topoisomerase II catalytic activity and decreased capacity to form drug-stabilized covalent protein-DNA complexes. The A
Autor:
Bridget T. Hill, L. K. Hosking, S. McClean, S. A. Shellard, W. C. M. Dempke, R. D. H. Whelan, M. Sehested, E. Friche, E. J. F. Demant, P. B. Jensen, B. P. Kopnin, B. Wolf, A. Seidel, M. Nickelsen, I. Brandt, G. Heinemann, M. Dietel, S. Bremer, T. Hoof, B. Tümmler, H. J. Broxterman, C. H. M. Versantvoort, C. M. Kuiper, N. Feller, G. J. Schuurhuis, J. Lankelma, S. Gupta, T. Tsuruo, C. Kim, S. Gollapudi, A. Bittl, M. Nap, W. Jäger, B. Lathan, N. Lang, N. T. Raikhlin, A. G. Perevozchikov, J. L. Volodina, T. Licht, H. H. Fiebig, K. J. Bross, F. Herrmann, R. Mertelsmann, I. Bashir, K. Sikora, C. S. Foster, M. Castagna, P. Viacava, M. Cianfrigliao, A. Favati, P. Collecchi, M. A. Caligo, G. Cipollini, G. Bevilacqua, D. Schrenk, T. W. Gant, J. A. Silverman, S. S. Thorgeirsson, A. Harstrick, Z. G. Zhang, H. J. Schmoll, Y. Rustum, M. Mitze, T. Beck, W. Weikel, C. Brumm, P. G. Knapstein, T. McDonald, P. Gardner, N. Kang, S. A. M. van der Heyden, H. J. Elst, U. Stein, B. Jandrig, H. Krause, P. Schmidt-Peter, J. Frege, V. Wunderlich, E. Boven, C. K. van Kalken, H. M. Pinedo, W. Gebauer, E. Fallgren-Gebauer, M. Diete, T. Wagner, M. R. Müller, K. Lennartz, H. R. Nowrousian, S. Seeber, A. A. Shtil, A. R. Kazarov, A. V. Gudkov, A. A. Stavrovskaya, F. H. Djuraeva, T. P. Stromskaya, A. Noller, G. Frese, M. Neumann, A. Wilisch, H. Probst, V. Gekeler, R. Handgretinger, H. Schmidt, C. P. Muller, R. Dopfer, T. Klingebiel, D. Niethammer, S. Weger, H. Diddens, E. Daumiller, A. Bunge, R. Lilischkis, A. Salmassi, M. Kopun, H. Scherthan, C. Granzow, I. Leuschner, D. Schmidt, H. Hoffmann, D. Harms, G. V. Scagliotli, E. Leonardo, S. Cappia, G. Esposito, M. Tombesi, M. Cianfriglia, G. V. Esposito, N. Merendino, M. Viora, M. Caserta, E. Tritarelli, E. Rocca, G. Boccoli, P. Samoggia, C. Fossati, U. Testa, C. Peschle, J. L. Darling, S. M. Ashmore, D. C. Peterson, D. G. T. Thomas, R. A. Kramer, R. Stanlunas, T. Summerhayes, T. Lion, R. H. Shoemaker, L. Wu, A. Smythe, M. R. Boyd, W. T. Beck, M. K. Danks, J. S. Wolverton, M. Chen, B. Y. Bugg, D. P. Suttle, C. V. Catapano, D. J. Fernandes, F. Gieseler, F. Boege, R. Erttmann, H. Arps, L. Zwelling, K. Wilms, H. Biersack, G. J. L. Kaspers, R. Pieters, E. Klumper, F. C. de Waal, E. R. van Wering, A. J. P. Veerman, C. A. Schmidt, F. Lorenz, A. Schäfer, A. Kirsch, W. Siegert, D. Huhn, W. E. Simon, G. Siebert, M. Schneider, M. Oettling, A. Reymann, R. Entmann, S. Schmidt, C. Woermann, C. Windmeier, I. Herzig, B. Schaefer, H. J. Heidebrecht, H. H. Wacker, H. Künnemann, Th. H. M. van Heijningen, M. L. Slovak, J. P. A. Baak, K. Steidtmann, A. -M. J. Fichtinger-Schepman, B. I. Hill, K. J. Scanlon, W. J. Zeller, G. Chen, J. A. Gietema, E. G. E de Vries, D.Th Sleijfer, P. H. B. Willemse, H. J. Guchelaar, D. R. A. Uges, P. Aulenbacher, R. Voegeli, N. H. Mulder, C. Skrezek, H. Bertermann, H. Eichholtz-Wirth, R. Born, H. Bier, M. Koch, G. Bernhardt, K. Hählen, H. Reile, C. H. van Zantwijk, T. Görögh, B. Lippert, J. A. Werner, J. E. Eickbohm, G. H. Mickiseh, M. M. Gottesman, I. Pastan, J. Hofmann, A. Wolf, M. Spitaler, G. Bock, H. Grunicke, H. Ponstingl, I. Roth, C. Dörner, G. Looft, G. J. Ossenkoppele, G. L. Scheffer, G. Atassi, A. Pierre, L. Kraus, S. Leonce, G. Regnier, A. Dhainaut, M. Stöhr, C. Rohlff, R. I. Glazer, Y. S. Cho-Chung, V. Höllt, M. Kouba, G. Vogt, H. Allmeier, N. I. Nissen, S. Cros, N. Guilbaud, T. Dunn, M. Berlion, J. P. Bizzari, A. M. Messing, A. Matuschek, I. Mutter, J. C. W. Kiwit, L. Bastian, P. E. Goretzki, A. Frilling, D. Simon, H. D. Röher, A. Reichle, F. Altmayr, J. Rastetter, C. Erbil, G. Jaques, M. Maasberg, K. Havemann, K. Häußermann, H. -J. Heidebrecht, W. Van de Vrie, E. E. O. Gheuens, N. M. C. Durante, E. A. De Bruijn, R. L. Marquet, A. T. Van Oosterom, A. M. M. Eggermont, M. W. Stow, S. E. Vickers, J. R. Warr, E. Roller, M. Eichelbaum, B. Klumpp, J. Krause, K. Schumacher, S. Hörner, A. Laßmann, U. Traugott, E. Schlick, D. Bürkle, BW Futscher, AF List, WS Dalton, E. Ladda, K. Bühl, A. Weimer, C. Eser, K. Hamprecht, K. P. Schalk, C. Jackisch, B. Brandt, M. Blum, F. Louwen, K. Schulz, J. P. Hanker, U. Rüther, A. Schmidt, H. A. G. Müller, C. Nunnensiek, H. Bader, F. Eisenberger, P. Jipp, B. Niethammer, C. Muller, V. Ling, F. Joncourt, S. Redmond, K. Buser, M. Fey, A. Tobler, K. Brunner, A. Gratwohl, T. Cerrry, V. Nuessler, R. Pelka-Fleischer, C. Nerl, B. Beckert, W. Wilmanns, S. Hegewisch-Becker, M. Fliegner, A. Zander, D. K. Hossfeld, J. Blanz, K. Mewes, G. Ehninger, K. -P. Zeller, H. Schuldes, G. Herrmann, W. Boeckmann, R. Schroeder, D. Jonas, K. -H. Zurborn, H. D. Bruhn, L. Uharek, B. Glass, W. Gassmann, H. Loeffler, W. Mueller-Ruohholtz, W. Mueller-Ruchholtz, K. Jaquet, H. Kreipe, J. Felgner, H. J. Radzun, M. R. Parwaresch, EA Kogan, NN Mazurenko, SM Sekamova, H. Wolf, K. Röhe, K. Wilkens, M. Clausen, E. Henze, J. van der Bosch, S. Rüller, M. Schlaak, U. Köhl, D. Schwabe, E. Rohrbach, E. Montag, S. Bauer, J. Cinatl, I. Cinatl, M. Mainke, H. Geiss, B. Kornhuber, H. Juhl, H. Stritzel, H. Kalhoff, W. Schniegel, T. Menke, B. Pröbsting, P. Schulze-Westhoff, J. Boos, J. Weidner, N. Wedemeyer, K. Wiedorn, Y. Ueda, S. Blasius, P. Wuisman, W. Böcker, A. Roessner, B. Dockhorn-Dworniczak, D. Ramm, J. Knebel, W. Sass, M. Aufderheide, J. Seifert
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 117:S89-S120
Autor:
R Kim, William T. Beck, Bernd Granzen, D. P. Suttle, Judith S. Wolverton, Mary K. Danks, M. Chen
Publisher Summary Clinically useful agents such as the epipodophyllotoxins (etoposide and teniposide), anthracyclines (doxorubicin and daunorubicin), and aminoacridines (arnsacrine) appear to exert their oncolytic effects at least in part through int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a941f08602450cefe3a32e3f0f70d398
https://doi.org/10.1016/s1054-3589(08)61136-9
https://doi.org/10.1016/s1054-3589(08)61136-9
Publikováno v:
Advances in pharmacology (San Diego, Calif.).
Autor:
M K, Danks, M R, Warmoth, E, Friche, B, Granzen, B Y, Bugg, W G, Harker, L A, Zwelling, B W, Futscher, D P, Suttle, W T, Beck
Publikováno v:
Cancer research. 53(6)
Five cell lines selected for resistance to the cytotoxicity of inhibitors of DNA topoisomerase II have point mutations in the gene that codes for the M(r) 170,000 form of this enzyme. In each case, the mutation results in an amino acid change in or n
Autor:
Qumsiyeh Mb, D. P. Suttle
Publikováno v:
The Journal of heredity. 81(2)
Careful analysis of G-band patterns in various rodent families allows identification of homology and thus accurate prediction of gene map positions. However, conclusions based on the synteny of genes without a careful study of chromosome evolution an