Výsledky vyhledávání - "D P, Reinhardt"

Gene expression during chemically induced liver fibrosis: effect of halofuginone on TGF-β signaling

Autor: Y. Hagai, Norifumi Kawada, Gadi Spira, Mark Pines, Rafael Bruck, G. Bilu, Yulia Gnainsky, Z. Kushnirsky, Hanne Volpin, T. A. Libermann, D. P. Reinhardt, Katsutoshi Yoshizato, Arnon Nagler, Olga Genina

Publikováno v: Cell and Tissue Research. 328:153-166

Hepatic fibrosis is associated with the activation of stellate cells (HSCs), the major source of extracellular matrix (ECM) proteins. Transforming growth factor-beta (TGF-beta), signaling via Smad3, is the most profibrogenic cytokine and the major pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4eafa822c838eecdeb369dc9ccd1e7
https://doi.org/10.1007/s00441-006-0330-1

Zobrazit plný text záznamu

Forschungsausblick

Autor: P. N. Robinson, D. P. Reinhardt

Publikováno v: Marfan-Syndrom ISBN: 9783798515659

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72fe3b437482a6dc58b8d1cf2ca29b3b
https://doi.org/10.1007/978-3-7985-1566-6_19

Zobrazit plný text záznamu

Bindegewebe

Autor: D. P. Reinhardt

Publikováno v: Marfan-Syndrom ISBN: 9783798515659

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0925eee60fa89152fdb6514c2358c0c6
https://doi.org/10.1007/978-3-7985-1566-6_6

Zobrazit plný text záznamu

Properties of the collagen type XVII ectodomain. Evidence for n- to c-terminal triple helix folding

Autor: S K, Areida, D P, Reinhardt, P K, Muller, P P, Fietzek, J, Kowitz, M P, Marinkovich, H, Notbohm

Publikováno v: The Journal of biological chemistry. 276(2)

Collagen XVII is a transmembrane component of hemidesmosomal cells with important functions in epithelial-basement membrane interactions. Here we report on properties of the extracellular ectodomain of collagen XVII, which harbors multiple collagenou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::febb84a9402d7de09ef7ee3236bd0faf
https://pubmed.ncbi.nlm.nih.gov/11042218

Zobrazit plný text záznamu

Mutations in calcium-binding epidermal growth factor modules render fibrillin-1 susceptible to proteolysis. A potential disease-causing mechanism in Marfan syndrome

Autor: D P, Reinhardt, R N, Ono, H, Notbohm, P K, Müller, H P, Bächinger, L Y, Sakai

Publikováno v: The Journal of biological chemistry. 275(16)

Most extracellular proteins consist of various modules with distinct functions. Mutations in one common type, the calcium-binding epidermal growth factor-like module (cbEGF), can lead to a variety of genetic disorders. Here, we describe as a model sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::203199f8443927b53f858c740d907406
https://pubmed.ncbi.nlm.nih.gov/10766875

Zobrazit plný text záznamu

Initial steps in assembly of microfibrils. Formation of disulfide-cross-linked multimers containing fibrillin-1

Autor: D P, Reinhardt, J E, Gambee, R N, Ono, H P, Bächinger, L Y, Sakai

Publikováno v: The Journal of biological chemistry. 275(3)

Fibrillins are the major constituents of extracellular microfibrils. How fibrillin molecules assemble into microfibrils is not known. Sequential extractions and pulse-chase labeling of organ cultures of embryonic chick aortae revealed rapid formation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9beea67236421841f2b1aaa4cd065e73
https://pubmed.ncbi.nlm.nih.gov/10636927

Zobrazit plný text záznamu

The structure and function of fibrillin

Autor: D P, Reinhardt, S C, Chalberg, L Y, Sakai

Publikováno v: Ciba Foundation symposium. 192

Fibrillin is a very large molecule whose primary structure is now known from the cloning and sequencing of 10 kb of cDNA. Immunohistochemical results suggest that one of the functions of fibrillin molecules is to contribute to the structure of the mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ff2fa26efa76ab9eafba1e7c0cf4b15
https://pubmed.ncbi.nlm.nih.gov/8575254

Zobrazit plný text záznamu

High Resolution Immuno-Electron Microscopy Reveals That Fetal Skin Contains Microfibrils which are Heteropolymers of Fibrillin-1 and Fibrillin-2

Autor: B. J. Dzamba, Catherine C. Ridgway, N. L. Charbonneau, R. N. Ono, D. P. Reinhardt, L. Y. Sakai, Douglas R. Keene

Publikováno v: Microscopy and Microanalysis. 4:1162-1163

Immunolocalization studies of neonate and older human tissues have previously demonstrated that fibrillin-1 is a component of elastin and non-elastin associated microfibrils. In sections taken from fixed, dehydrated and embedded tissue, microfibrils

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d29225be992f95703f7eca9ae4f8f0f6
https://doi.org/10.1017/s1431927600025939

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání