Výsledky vyhledávání - "D P, Nowotnik"

Improved targeting of platinum chemotherapeutics

Autor: Q. Zhang, D. P. Nowotnik, Xinjian Lin, John R. Rice, Donald R. Stewart, Stephen B. Howell

Publikováno v: European Journal of Cancer. 40:291-297

AP5280 is a novel N -(2-hydroxypropyl)methacrylamide (HPMA) copolymer-bound platinum (Pt) therapeutic designed to increase the therapeutic index relative to conventional, small-molecule platinum agents. The platinum–polymer construct accumulates in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5b612ae623c76d77e2d2befe9e098d8
https://doi.org/10.1016/j.ejca.2003.09.022

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Linkage Isomerization of MSCN(CDOH)2(CDO)BMe to MNCS(CDOH)2(CDO)BMe (M = Tc, Re). Crystal Structures of TcNCS(CDOH)2(CDO)BMe, ReNCS(CDOH)2(CDO)BMe, and ReSCN(CDOH)2(CDO)BMe

Autor: A. D. Nunn, John D. Lydon, M. M. Halihan, Silvia S. Jurisson, Charles L. Barnes, D. P. Nowotnik

Publikováno v: Inorganic Chemistry. 37:1922-1928

The 7-coordinate technetium(III) and rhenium(III) monocapped tris(dioxime) complexes [MX(dioxime)3BR] have been prepared in which the seventh ligand, X, is thiocyanate or hydroxide (M = Tc, Re; R = Me, Et). Both the N- and S-bound thiocyanate linkage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed3f4a3af8fa8a807048c315947953ef
https://doi.org/10.1021/ic971145i

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Synthesis of Functionalized 3,3,9,9-Tetramethyl-4,8-Diazaundecane-2,10-Dione Dioximes (Propylene Amine Oximes, PnAOs)

Autor: W. Zeng, K. Ramalingam, D. P. Nowotnik, P. Nanjappan

Publikováno v: Synthetic Communications. 25:743-752

The syntheses of several new derivatives of PnAO and their chloronitroso precursors are described. The PnAOs were prepared by an improvement of the reported general procedure. An unexpected product, an isooxalone, was formed while attempting to prepa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5b22d2801429b1b46bc17ad937ab0d2
https://doi.org/10.1080/00397919508011412

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The Determination of Charge of Cationic99mTc-Radiopharmaceuticals

Autor: D. P. Nowotnik, A. L. M. Riley

Publikováno v: Journal of Liquid Chromatography. 17:533-548

Cation exchange HPLC methods for the determination of charge of cationic 99mTc. complexes were developed, based on a method described previously for anions. Nonspecific retention of Hpophilic complexes was reduced by the addition of acetonitrile. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0074a202d93e39cc8415ebe4ca49b7c
https://doi.org/10.1080/10826079408013158

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An efficient synthesis of some 6-substituted 4,8-diaza-3,3,9,9- tetramethylundeca-2,10-dione dioximes (propylene amine oximes, PnAOs): Ligands for 99mTc complexes used in structure distribution relationship (SDR) studies

Autor: D. P. Nowotnik, P. Nanjappan, N. Raju, K. Ramalingam

Publikováno v: Tetrahedron. 50:8617-8632

Technetium complexes of the ligand PnAO [4,8-diaza-3,3,9,9-tetramethylundeca-2,10-dione dioximes (3)] are of interest as commercial radiopharmaceuticals. In general, PnAOs are synthesized by alkylation of a propylenediamine derivative with 3-chloro-3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09bf81a93900306b82be5977e95730d0
https://doi.org/10.1016/s0040-4020(01)85336-9

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A Comparison of Methods for the Determination of Dead Time in a Reversed-Phase High-Performance Liquid Chromatography System Used for the Measurement of Lipophilicity

Autor: R. K. Narra, D. P. Nowotnik

Publikováno v: Journal of Liquid Chromatography. 16:3919-3932

The dead time (void volume) of a reversed-phase system utilizing a column containing the divinylbenzene-styrene copolymer packing (PRP-1) was determined using candidate dead time markers, and two series of homologues, n-alkanols and n-alkyl benzenes.

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https://doi.org/10.1080/10826079308019677

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ChemInform Abstract: Syntheses of Some Nitroimidazole Substituted Boronic Acids: Precursors to Technetium-99m Complexes with Potential for Imaging Hypoxic Tissue

Autor: D. P. Nowotnik, K. Ramalingam, N. Raju

Publikováno v: ChemInform. 24

A number of nitroimidazole substituted alkyl and aryl-boronic acids were synthesized as precursors to technetium-99m complexes under investigation as potential imaging agents of hypoxia. Compounds were prepared with the nitro group either in the 2- o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db8f0d4dca346416c4383ffdbdc5b345
https://doi.org/10.1002/chin.199309199

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