Zobrazeno 1 - 8
of 8
pro vyhledávání: '"D P, Hesson"'
Autor:
R. J. Ardecky, D. P. Hesson, G. V. Rao, M. Forbes, Daniel L. Dexter, Shih-Fong Chen, L. M. Papp
Publikováno v:
Biochemical Pharmacology. 40:709-714
The novel anticancer drug candidate brequinar sodium [DuP 785, NSC 368390, 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinoline carboxylic acid sodium salt] inhibits dihydroorotate dehydrogenase, the fourth enzyme in the de novo pyrimidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ead0bd6f642f38eed03b609e71a97c9c
https://doi.org/10.1016/0006-2952(90)90305-5
https://doi.org/10.1016/0006-2952(90)90305-5
Publikováno v:
Molecular pharmacology. 40(5)
A new class of antimitotic agents, derivatives of 2-styrylquinazolin-4(3H)-one (SQZ), was recently described [J. Med. Chem. 33:1721-1728 (1990)]. Because they appeared to interact at a new ligand binding site on tubulin, we attempted to determine the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::584b81fe04921dc19859c110c1bd7e03
https://pubmed.ncbi.nlm.nih.gov/1944246
https://pubmed.ncbi.nlm.nih.gov/1944246
Publikováno v:
ChemInform. 21
A novel series of 2-styrylquinazolin-4(3H-ones which inhibited tubulin polymerization and the growth of L1210 murine leukemia cells was discovered. Extensive structure-activity relationship studies suggest that the entire quinazolinone structure was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e78e6a838114cf8092867cc15088de9
https://doi.org/10.1002/chin.199049199
https://doi.org/10.1002/chin.199049199
Publikováno v:
Biochemical pharmacology. 40(4)
The novel anticancer drug candidate brequinar sodium [DuP 785, NSC 368390, 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinoline carboxylic acid sodium salt] inhibits dihydroorotate dehydrogenase, the fourth enzyme in the de novo pyrimidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0801d6749c1bbdae4d6d9122ade786aa
https://pubmed.ncbi.nlm.nih.gov/2386542
https://pubmed.ncbi.nlm.nih.gov/2386542
Publikováno v:
Journal of medicinal chemistry. 33(6)
A novel series of 2-styrylquinazolin-4(3H-ones which inhibited tubulin polymerization and the growth of L1210 murine leukemia cells was discovered. Extensive structure-activity relationship studies suggest that the entire quinazolinone structure was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9757862c242e83a6bf005b66cc83437b
https://pubmed.ncbi.nlm.nih.gov/2088342
https://pubmed.ncbi.nlm.nih.gov/2088342
Autor:
J. E. Baldwin, D. P. Hesson
Publikováno v:
Chemischer Informationsdienst. 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c370eeacb9fbd0aa59053107bfa6234d
https://doi.org/10.1002/chin.197701232
https://doi.org/10.1002/chin.197701232
Publikováno v:
Chemischer Informationsdienst. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a67e40647627102b7cc837f997aab21
https://doi.org/10.1002/chin.198042288
https://doi.org/10.1002/chin.198042288
Autor:
D L, Dexter, D P, Hesson, R J, Ardecky, G V, Rao, D L, Tippett, B A, Dusak, K D, Paull, J, Plowman, B M, DeLarco, V L, Narayanan
Publikováno v:
Cancer research. 45(11 Pt 1)
A novel, substituted 4-quinolinecarboxylic acid (NSC 339768) demonstrated antitumor activity against L1210 leukemia and B16 melanoma in the National Cancer Institute's Developmental Therapeutics Program. An extensive analogue synthesis program was in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b99680b424d1d0d9511a5eb03e151129
https://pubmed.ncbi.nlm.nih.gov/4053030
https://pubmed.ncbi.nlm.nih.gov/4053030