Výsledky vyhledávání

alpha-Alkyl-alpha-amino-beta-sulphone hydroxamates as potent MMP inhibitors that spare MMP-1

Autor: D P, Becker, G, DeCrescenzo, J, Freskos, D P, Getman, S L, Hockerman, M, Li, P, Mehta, G E, Munie, C, Swearingen

Publikováno v: Bioorganicmedicinal chemistry letters. 11(20)

A series of alpha-alkyl-alpha-amino-beta-sulphone hydroxamates was prepared and evaluated for potency versus MMP-2 and MMP-13, and for selectivity versus MMP-1. Low nanomolar potency was obtained with selectivity versus MMP-1 ranging from10 to1000. S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::163df3817d45a01375edc915f8658ad8
https://pubmed.ncbi.nlm.nih.gov/11591510

Zobrazit plný text záznamu

Selective peptidic and peptidomimetic inhibitors of Candida albicans myristoylCoA: protein N-myristoyltransferase: a new approach to antifungal therapy

Autor: J A, Sikorski, B, Devadas, M E, Zupec, S K, Freeman, D L, Brown, H F, Lu, S, Nagarajan, P P, Mehta, A C, Wade, N S, Kishore, M L, Bryant, D P, Getman, C A, McWherter, J I, Gordon

Publikováno v: Biopolymers. 43(1)

MyristoylCoA: protein N-myristoyltransferase (NMT) catalyzes the cotranslational covalent attachment of a rare cellular fatty acid, myristate, to the N-terminal Gly residue of a variety of eukaryotic proteins. The myristoyl moiety is often essential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3f31eb6fcf10f1caf89515f800ac81ca
https://pubmed.ncbi.nlm.nih.gov/9174411

Zobrazit plný text záznamu

Kinetic and structural evidence for a sequential ordered Bi Bi mechanism of catalysis by Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase

Autor: D A, Rudnick, C A, McWherter, W J, Rocque, P J, Lennon, D P, Getman, J I, Gordon

Publikováno v: The Journal of biological chemistry. 266(15)

The mechanism of catalysis of Escherichia coli-derived Saccharomyces cerevisiae myristoyl-CoA: protein N-myristoyltransferase (NMT) has been characterized. Previous studies indicated that a high affinity reaction intermediate forms between NMT and my

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::38b444a6eb545490ece87fd4e2ec9a01
https://pubmed.ncbi.nlm.nih.gov/2033063

Zobrazit plný text záznamu

Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. Mechanism-based discrimination between calcium-dependent and -independent phospholipases A2

Autor: S L, Hazen, L A, Zupan, R H, Weiss, D P, Getman, R W, Gross

Publikováno v: The Journal of biological chemistry. 266(11)

The majority of phospholipase A2 activity in myocardium is calcium-independent and selective for hydrolysis of plasmalogen substrate (Wolf, R. A., and Gross, R. W. (1985) J. Biol. Chem. 260, 7295-7303; Hazen, S. L., Stuppy, R. J., and Gross, R. W. (1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eb3b0d071a14a324ad492dcfc34241b0
https://pubmed.ncbi.nlm.nih.gov/2016324

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání