Cenicriviroc, a dual CCR2 and CCR5 antagonist leads to a reduction in plasma fibrotic biomarkers in persons living with HIV on antiretroviral therapy

Autor: S. Bowler, C. Siriwardhana, B. L. Mitchell, M. L. D’Antoni, D. Ogata-Arakaki, S. Souza, R. Yee, L. M. A. Gangcuangco, D. C. Chow, L. C. Ndhlovu, C. Shikuma

Publikováno v: HIV Research & Clinical Practice, Vol 20, Iss 4-5, Pp 123-129 (2019)

Background: Chronic HIV is associated with increased inflammation and tissue fibrosis despite suppressive antiretroviral therapy (ART). Monocytes and macrophages have been implicated in the pathogenesis of fibrosis, facilitated by chemokine receptor

Externí odkaz: https://doaj.org/article/1943ada5fcc04469a972bdd3be6591bc

Neurological outcomes in late HIV infection: adverse impact of neurological impairment on survival and protective effect of antiviral therapy

Autor: David B. Clifford, Richard W. Price, B. Sinclair, J. Weiler-Einstein, Curtis Cooper, C. Frank, C. Kessler, Susan Swindells, P. Clax, M. Crawford, Ann C. Collier, Mario Guerrero, A. Kenton, E. Scerpella, Harold A. Kessler, C. Ehmann, D. Dorfman, Monica Millard, M. Brady, Ian Frank, Constantin T. Yiannoutsos, R. Snyder, Margaret A. Fischl, Camillo Marra, M. Rinki, T. Flynn, C. Olson, Keith Chirgwin, Peter T. Frame, G. Rudberg, D. B. Brettler, Donald E. Craven, S. Kohrs, C. Van Der Horst, Michael J. Borucki, I. Lopez, Lawrence Zaborski, S. Deloach, Karen Marder, J. Reid, E. Cooney, J. Hunkler, S. Seremetis, Christine Wanke, P. Galatas, Fred T. Valentine, A. Rubinstein, Kathleen Squires, C. Kapoor, A. Sosa, I. Matozzo, William G. Powderly, K. Todd, Kenneth H. Fife, S. Szebenyi, Beverly Putnam, John J. Sidtis, Alex Tselis, Alejo Erice, Debbie Slamowitz, Dana Cummings, B. McCulloch, Colin D. Hall, Mary A. Vogler, R. Sociro, Ronald J. Ellis, Michael M. Lederman, Harry Hollander, Bruce A. Cohen, Stacy M. Stabler, Kevin Robertson, Princy Kumar, Keith Henry, John Gill, J. Walker, Laura Ponticello, Guillermo J. Vázquez, Robert G. Holloway, S. Kruger, Wendy T. Robertson, P. Timmons, P. Forand, M. J. Nealon, David M. Simpson, M. A. South, K. Hoots, Allan Rodriguez, D. Ogata-Arakaki, H. Saba, Y. Butler, M. E. Eyster, C. Quinlan, Kenneth L. Tyler, S. Giambartolomei, Robert Delapenha, M. Glicksman, Michael S. Saag, B. Tannenbaum, T. D. Coates

Publikováno v: AIDS. 13:1677-1685

Objective: In a large multi-center clinical trial of combination reverse transcriptase inhibitors (RTls), we assessed the impact of antiretroviral therapy on neurological function, the relationship between neurological and systemic benefit, and the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a99adc11b2d91aee86ddef3471c87b51
https://doi.org/10.1097/00002030-199909100-00011

Trimetrexate-leucovorin dosage evaluation study for treatment of Pneumocystis carinii pneumonia

Autor: F. R. Sattler, C. J. Allegra, T. D. Verdegem, B. Akil, C. U. Tuazon, C. Hughlett, D. Ogata-Arakaki, J. Feinberg, J. Shelhamer, H. C. Lane, R. Davis, C. T. Boylen, J. M. Leedom, H. Masur

Publikováno v: The Journal of infectious diseases. 161(1)

To determine the maximal tolerable dosage of trimetrexate for treatment of pneumocystis pneumonia, 25 patients were treated each day with 45 mg/m2 of trimetrexate and 80 mg/m2 of leucovorin; 10 received 60 mg/m2 and 80 mg/m2; 12 received 60 mg/m2 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a027854439e9e1501164aa6340f07cb
https://pubmed.ncbi.nlm.nih.gov/2136905

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Treatment of Pneumocystis carinii pneumonia with trimetrexate in acquired immunodeficiency syndrome (AIDS)

Autor: C J, Allegra, B A, Chabner, C U, Tuazon, D, Ogata-Arakaki, B, Baird, J C, Drake, H, Masur

Publikováno v: Seminars in oncology. 15(2 Suppl 2)

In vitro studies have shown that trimetrexate, a lipid-soluble analogue of methotrexate, is 1500 times more potent than trimethoprim as an inhibitor of dihydrofolate reductase from Pneumocystis carinii. Furthermore, trimetrexate is readily taken up b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0fc1971e4de7be6b18da83a97d99733e
https://pubmed.ncbi.nlm.nih.gov/2966985