The ex vivo on-ECMO amputated human limb model of atherosclerosis

Autor: A Hartley, S Owen, M Caga-Anan, J Afoke, J Shalhoub, K Hassen, J Mason, D O Haskard, R Khamis

Publikováno v: European Heart Journal. 43

Introduction The preclinical study of atherosclerosis has been traditionally centred around the use of small animal models, translating to large animal models prior to first-in-man studies. We propose to disrupt this paradigm by designing an ex vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::082becebf1b93e55162ef97571fa1004
https://doi.org/10.1093/eurheartj/ehac544.3041

A low balance between microparticles expressing tissue factor pathway inhibitor and tissue factor is associated with thrombosis in Behçet's Syndrome

Autor: E. Khan, N. L. Ambrose, J. Ahnström, A. P. Kiprianos, M. R. Stanford, D. Eleftheriou, P.A. Brogan, J. C. Mason, M. Johns, M. A. Laffan, D. O. Haskard

Publikováno v: Khan, E, Ambrose, N L, Ahnström, J, Kiprianos, A P, Stanford, M R, Eleftheriou, D, Brogan, P A, Mason, J C, Johns, M, Laffan, M A & Haskard, D O 2016, ' A low balance between microparticles expressing tissue factor pathway inhibitor and tissue factor is associated with thrombosis in Behçet's Syndrome ', Scientific Reports, vol. 6, 38104 . https://doi.org/10.1038/srep38104

Thrombosis is common in Behçet's Syndrome (BS), and there is a need for better biomarkers for risk assessment. As microparticles expressing Tissue Factor (TF) can contribute to thrombosis in preclinical models, we investigated whether plasma micropa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5305f8e107a25ad3c3e527a1ee3bb02e
https://kclpure.kcl.ac.uk/ws/files/62465411/A_low_balance_between_KHAN_Accepted_26OCT2016_GOLD_VoR_CCBY.pdf

Ex vivo adenovirus-mediated gene transfer and immunomodulatory protein production in human cornea

Autor: Andrew P. Byrnes, Margaret J. Dallman, Daniel F P Larkin, D. O. Haskard, Alasdair M. Rankin, Andrew J.T. George, Z. Fehervari, Matthew J.A. Wood, Haluk Barbaros Oral

Publikováno v: Scopus-Elsevier

One attractive strategy to prevent or control allograft rejection is to genetically modify the donor tissue before transplantation. In this study, we have examined the feasibility of gene transfer to human corneal endothelium, using a number of recom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283795b632d66042bb586c1ff4a6c9b4
https://doi.org/10.1038/sj.gt.3300443

Human umbilical vein and dermal microvascular endothelial cells show heterogeneity in response to PKC activation

Autor: Helen Yarwood, Justin C. Mason, D. O. Haskard, Katharine Sugars

Publikováno v: American Journal of Physiology-Cell Physiology. 273:C1233-C1240

Changes in endothelial cell (EC) phenotype are central to the function of endothelium in inflammation. Although these events mainly occur in the microvasculature, previous studies have predominantly used large-vessel EC. Using enzyme-linked immunosor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a569f011cc081db4a11588c35b670dce
https://doi.org/10.1152/ajpcell.1997.273.4.c1233

IN VITRO ACCOMMODATION OF IMMORTALIZED PORCINE ENDOTHELIAL CELLS

Autor: Robert I. Lechler, Anthony Dorling, Claire J. Stocker, D. O. Haskard, Twee Tsao

Publikováno v: Transplantation. 62:1127-1136

The capacity of vascularized xenografts to survive in the face of normal levels of circulating antigraft antibodies and complement has been ascribed to a phenomenon referred to as "endothelial cell accommodation." The mechanisms whereby accommodation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e1f1b03e66e50a7d198b33146cafc2
https://doi.org/10.1097/00007890-199610270-00018