Zobrazeno 1 - 3
of 3
pro vyhledávání: '"D O, Whipple"'
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 3(10)
Camptothecin analogues such as topotecan increase the number of covalent topoisomerase I-DNA complexes, which, in turn, have been proposed to initiate apoptosis. If induction of apoptosis by the camptothecins is, in fact, dependent on the formation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::687eed7d1055a6d219bbeaea5897b3b9
https://pubmed.ncbi.nlm.nih.gov/9815557
https://pubmed.ncbi.nlm.nih.gov/9815557
Publikováno v:
Cytometry. 32(3)
Carboxylesterases are a ubiquitous class of enzymes thought to be involved in xenobiotic metabolism and detoxification. Primary amino acid sequence data suggest that these proteins localize to the endoplasmic reticulum. However, since this family of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::934fc8caa38f94f02a56111b7a8973ec
https://pubmed.ncbi.nlm.nih.gov/9667512
https://pubmed.ncbi.nlm.nih.gov/9667512
Publikováno v:
Cancer research. 56(7)
DNA topoisomerase I is the cytotoxic target for chemotherapeutic agents of the camptothecin class. The cytotoxicity of these drugs is thought to be mediated by a dose-dependent increase in topoisomerase I molecules bound to DNA, resulting in DNA dama
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::27cf691ad935961250b5e7cb5c78f892
https://pubmed.ncbi.nlm.nih.gov/8603418
https://pubmed.ncbi.nlm.nih.gov/8603418