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pro vyhledávání: '"D O, Scott"'
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 22(3)
Recently, analytical methods have become available for determination of both the lactone (active form) and the carboxylate (inactive form) forms of 20(S)-camptothecin in biological fluids. Studies in our laboratory have shown that there are significa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e97021c8ba8a1ed5aa6becc9e9be7356
https://pubmed.ncbi.nlm.nih.gov/8070321
https://pubmed.ncbi.nlm.nih.gov/8070321
Publikováno v:
Pharmaceutical research. 10(10)
20(S)-Camptothecin exists in equilibrium between its lactone (CPT) and its carboxylate forms (Na-CPT) under stimulated physiological conditions, with the equilibrium favoring the carboxylate form. The rates of lactone hydrolysis were studied in plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::43bc548692a9dc3a3ee94b209ee505c0
https://pubmed.ncbi.nlm.nih.gov/8272406
https://pubmed.ncbi.nlm.nih.gov/8272406
Autor:
D O, Scott, C E, Lunte
Publikováno v:
Pharmaceutical research. 10(3)
Methods for continuous in vivo sampling in the bile, blood, and liver extracellular fluid are described. These methods are based on microdialysis sampling in anesthetized rats. A new flow-through microdialysis probe is described for sampling bile whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db617e97c7cecd4f58afa8a95e55ac2a
https://pubmed.ncbi.nlm.nih.gov/8464805
https://pubmed.ncbi.nlm.nih.gov/8464805
Publikováno v:
Pharmaceutical research. 8(3)
In vivo microdialysis sampling coupled to liquid chromatography was used to study acetaminophen disposition in anesthetized rats. The pharmacokinetics of acetaminophen and its sulfate and glucuronide metabolites were determined using both microdialys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::501827f17d297718b5649ec5cadebc2f
https://pubmed.ncbi.nlm.nih.gov/2052531
https://pubmed.ncbi.nlm.nih.gov/2052531
Publikováno v:
Pharmaceutical research. 7(10)
The use of microdialysis sampling to study the binding of drugs to plasma proteins was evaluated. Microdialysis sampling is accomplished by placing a short length of dialysis fiber in the sample and perfusing the fiber with a vehicle. Small molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::668ab1b0cde047c5694f5b00a1313788
https://pubmed.ncbi.nlm.nih.gov/2281040
https://pubmed.ncbi.nlm.nih.gov/2281040