Zobrazeno 1 - 10
of 16
pro vyhledávání: '"D O, Martin"'
Autor:
Firyal Ramzan, Ashish Kumar, Fatima Abrar, Rachel A. V. Gray, Zurie E. Campbell, Lucia Meng Qi Liao, Anthony Dang, Oluwadurotimi Akanni, Colm Guyn, Dale D. O. Martin
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Multisystem proteinopathy (MSP) is a rare, dominantly inherited disorder that includes a cluster of diseases, including frontotemporal dementia, inclusion body myopathy, and Paget’s disease of bone. MSP is caused by mutations in the gene e
Externí odkaz:
https://doaj.org/article/54a17239fd5f492f81788d8f358ec73c
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
One of the first molecular events in neurodegenerative diseases, regardless of etiology, is protein mislocalization. Protein mislocalization in neurons is often linked to proteostasis deficiencies leading to the build-up of misfolded proteins and/or
Externí odkaz:
https://doaj.org/article/420de882f9c4473b80b4479ebe0f46d9
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Huntington disease is an autosomal dominant neurodegenerative disorder which is caused by a CAG repeat expansion in the HTT gene that codes for an elongated polyglutamine tract in the huntingtin (HTT) protein. Huntingtin is subjected to
Externí odkaz:
https://doaj.org/article/2dceb005525940f3bd67949a75fac1f7
Autor:
Dagmar E. Ehrnhoefer, Dale D. O. Martin, Mandi E. Schmidt, Xiaofan Qiu, Safia Ladha, Nicholas S. Caron, Niels H. Skotte, Yen T. N. Nguyen, Kuljeet Vaid, Amber L. Southwell, Sabine Engemann, Sonia Franciosi, Michael R. Hayden
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-16 (2018)
Abstract Huntington disease (HD) is caused by the expression of mutant huntingtin (mHTT) bearing a polyglutamine expansion. In HD, mHTT accumulation is accompanied by a dysfunction in basal autophagy, which manifests as specific defects in cargo load
Externí odkaz:
https://doaj.org/article/3098d7176f61480fbe25947e9399afed
Autor:
Firyal Ramzan, Fatima Abrar, Ashish Kumar, Lucia Meng Qi Liao, Zurie E. Campbell, Rachel V. Gray, Oluwadurotimi Akanni, Colm Guyn, Dale D. O. Martin
Multisystem proteinopathy (MSP) is a rare dominantly-inherited disorder that includes a cluster of diseases, including frontotemporal dementia, inclusion body myopathy, and Paget’s disease of bone. MSP is caused by mutations in the gene encoding Va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72f2ee1ef68a68b001b6fe7f0126e491
https://doi.org/10.1101/2023.03.31.531359
https://doi.org/10.1101/2023.03.31.531359
Autor:
Shaun S Sanders, Dale D O Martin, Stefanie L Butland, Mathieu Lavallée-Adam, Diego Calzolari, Chris Kay, John R Yates, Michael R Hayden
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 8, p e1004405 (2015)
Palmitoylation involves the reversible posttranslational addition of palmitate to cysteines and promotes membrane binding and subcellular localization. Recent advancements in the detection and identification of palmitoylated proteins have led to mult
Externí odkaz:
https://doaj.org/article/4e622abde3914052af71758d61c22c55
Publikováno v:
Journal of Visualized Experiments.
Fatty acylation, the covalent addition of saturated fatty acids to protein substrates, is important in regulating a myriad of cellular functions in addition to its implications in cancer and neurodegenerative diseases. Recent developments in fatty ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba9e31bc7968b6ff8e3f3518a48faac
https://doi.org/10.3791/62107-v
https://doi.org/10.3791/62107-v
Autor:
Amit P Bhavsar, Nat F Brown, Jan Stoepel, Marcel Wiermer, Dale D O Martin, Karolynn J Hsu, Koshi Imami, Colin J Ross, Michael R Hayden, Leonard J Foster, Xin Li, Phil Hieter, B Brett Finlay
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003518 (2013)
To further its pathogenesis, S. Typhimurium delivers effector proteins into host cells, including the novel E3 ubiquitin ligase (NEL) effector SspH2. Using model systems in a cross-kingdom approach we gained further insight into the molecular functio
Externí odkaz:
https://doaj.org/article/18d8300ef9bc4b3f815eb0cf4287600f
Autor:
Nicolas Wold, F.H.R.S. Kenneth Stein M.D., Benzy J. Padanilam, F.H.R.S. Bruce Goldner M.D., F.H.R.S. Suneet Mittal M.D., Allen Ciuffo, Nigel Gupta, D O Martin Burke, F.H.R.S. Devi Nair M.D., Peter Gallagher, F B S Eric Hammill
Publikováno v:
Journal of Cardiovascular Electrophysiology. 27:1199-1205
Anatomically Designed Quadripolar LV LeadsIntroduction The safety and efficacy of a novel family of quadripolar left ventricular (LV) pacing leads designed to pace from nonapical regions of the LV with low pacing capture thresholds was studied in pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d078cda00a31b05a3c40f169cb8fb1aa
https://doi.org/10.1111/jce.13044
https://doi.org/10.1111/jce.13044
Publikováno v:
Pacing and Clinical Electrophysiology. 39:502-506
A 56-year-old man presented for lead extraction of a left ventricular (LV) lead that had been deactivated due to hiccups and of a right ventricular (RV) lead with a high threshold. Pus was noted upon entering the pocket. The right atrial and RV leads
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e143694ecb32cc39a0da2ec1429cea6f
https://doi.org/10.1111/pace.12822
https://doi.org/10.1111/pace.12822