Výsledky vyhledávání

Activation of RAGE leads to the release of glutamate from astrocytes and stimulates calcium signal in neurons

Autor: Plamena R. Angelova, A. V. Kamynina, Olga M. Volpina, Andrey Y. Abramov, Noemí Esteras, D. O. Koroev

Publikováno v: Journal of Cellular Physiology

The receptor for advanced glycation end products (RAGE) is a signal receptor first shown to be activated by advanced glycation end products, but also by a variety of signal molecules, including pathological advanced oxidation protein products and β�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::945e8d897d55559eace0f330ec85d378
https://doi.org/10.1002/jcp.30324

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Optimization of Solid-Phase Synthesis of the 1-40 Beta-Amyloid and Preparation of Antibodies Revealing It under Immunoblotting Conditions

Autor: T. D. Volkova, D. O. Koroev, A. V. Kamynina, A. V. Avetisyan, Olga M. Volpina, M. P. Filatova

Publikováno v: Russian Journal of Bioorganic Chemistry. 46:217-222

The solid-phase synthesis and purification of the 1-40 sequence of the human beta-amyloid were optimized, resulting in a preparation of a product with a high yield and homogeneity more than 95%. The synthetic peptide is capable of forming oligomers.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0ab6f0075f04e61c224e0fa1d7d724a
https://doi.org/10.1134/s1068162020020181

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Akademický článek

Participation of various populations lymphocytes in formation of protection from meningococcosis

Autor: O V Kotelnikova, E J Drozzina, O M Volpina, D O Koroev, M P Filatova, A P Alliluev

Publikováno v: RUDN Journal of Medicine, Vol 0, Iss 2, Pp 10-16 (2010)

Immunization of mice by synthetic peptides fragments of meningococcus external membrane fibers caused the expressed protection of animals against infection caused by live virulent meningococcus culture serogroup A, B and C. There are leading part T-l

Externí odkaz: https://doaj.org/article/e161261146ef405ab153406f4532e804

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Therapeutic Monitoring and Prediction of the Efficacy of Neurotrophic Therapy in Patients with Amnestic-Type Mild Cognitive Decline Syndrome

Autor: E. V. Ponomareva, D. O. Koroev, A. V. Kamynina, Olga M. Volpina, I. V. Kolykhalov, Ya. B. Fedorova, Selezneva Nd, Gavrilova Si

Publikováno v: Neuroscience and Behavioral Physiology. 49:523-534

Objectives. Therapeutic monitoring and evaluation of the efficacy of neurotrophic therapy in patients with amnestic-type mild cognitive decline syndrome (aMCI) were performed in a model using courses of cerebrolysin. Materials and methods. A total of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51dc0306b7a93c88381ec917e4e56043
https://doi.org/10.1007/s11055-019-00765-5

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Proteolytic degradation patterns of the receptor for advanced glycation end products peptide fragments correlate with their neuroprotective activity in Alzheimer's disease models

Autor: T. D. Volkova, D. O. Koroev, Natalia V. Bobkova, Marina V. Serebryakova, A. V. Kamynina, Olga M. Volpina

Publikováno v: Drug development researchREFERENCES. 82(8)

The receptor for advanced glycation end products (RAGE) plays an essential role in Alzheimer's disease (AD). We previously demonstrated that a fragment (60-76) of RAGE improved the memory of olfactory bulbectomized (OBX) and Tg 5 × FAD mice - animal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd021d46f91e4e0a9ff5d7a7efd2f34
https://pubmed.ncbi.nlm.nih.gov/34060112

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MECHANISM OF PATHOLOGICAL ACTION OF AMYLOID-BETA ON NEURONAL MITOCHONDRIA IN ALZHEIMER'S TYPE NEURODEGENERATION, THERAPEUTIC EFFECT OF THE SYNTHETIC FRAGMENT OF RAGE

Autor: D. O. Koroev, Samson M. Balasanyants, Natalia V. Bobkova, Ruben A. Simonyan, Olga M. Volpina, Roman A. Zinovkin, A. V. Avetisyan

Publikováno v: Neuroscience for Medicine and Psychology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7ebe8848e05a568c70b55050c5a2964
https://doi.org/10.29003/m902.sudak.ns2020-16/52

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A synthetic fragment 60–70 of the receptor for advanced glycation end products exhibits a therapeutic effect in an animal model of Alzheimer’s disease

Autor: N. V. Bobkova, T. D. Volkova, A. V. Kamynina, D. O. Koroev, Olga M. Volpina, Samson M. Balasanyants, M. P. Filatova, A. N. Samokhin

Publikováno v: Russian Journal of Bioorganic Chemistry. 43:150-154

Six synthetic peptides overlapping a fragment 60–76 of the receptor for advanced glycation end products (RAGE) were studied on a protective effect on spatial memory of animals in the experimental model of Alzheimer’s disease. It was shown that on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02751f82f59f78b2da625c6937eb784b
https://doi.org/10.1134/s1068162017020066

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Immunological approach to structural-functional mapping of the membrane receptors

Autor: Inna V. Nesterova, N. I. Medvinskaya, N. V. Bobkova, A. N. Samokhin, D. O. Koroev, Vasily Vorobyov, Olga M. Volpina

Publikováno v: Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology. 10:311-318

In order to study the structural and functional specificity of different fragments of extracellular domains of the membrane receptors, their immunological blockade and analysis of changes in brain function in health and disease were carried out. Effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9fc66105ba97acc240b8685abeb80a5e
https://doi.org/10.1134/s199074781603017x

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