Zobrazeno 1 - 10
of 16
pro vyhledávání: '"D O, Calligaro"'
Autor:
J S, Kennedy, F P, Bymaster, L, Schuh, D O, Calligaro, G, Nomikos, C C, Felder, M, Bernauer, B J, Kinon, R W, Baker, D, Hay, H J, Roth, M, Dossenbach, C, Kaiser, C M, Beasley, J H, Holcombe, M B, Effron, A, Breier
Publikováno v:
International journal of geriatric psychiatry. 16
Olanzapine (OLZ) is unique among currently available antipsychotic medications in its antagonism of a range of receptor systems including dopamine, norepinephrine, serotonin, acetylcholine, and histamine. Olanzapine's mechanistic complexity provides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::804501eee12f73d97564694a6a147ff1
https://pubmed.ncbi.nlm.nih.gov/11748788
https://pubmed.ncbi.nlm.nih.gov/11748788
Autor:
K, Rasmussen, D O, Calligaro, J F, Czachura, L J, Dreshfield-Ahmad, D C, Evans, S K, Hemrick-Luecke, M J, Kallman, W T, Kendrick, J D, Leander, D L, Nelson, C D, Overshiner, D B, Wainscott, M C, Wolff, D T, Wong, T A, Branchek, J M, Zgombick, Y C, Xu
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 294(2)
LY426965 [(2S)-(+)-1-cyclohexyl-4-[4-(2-methoxyphenyl)-1-piperazinyl]2-methyl- 2-phenyl-1-butanone monohydrochloride] is a novel compound with high affinity for the cloned human 5-hydroxytryptamine (HT)(1A) receptor (K(i) = 4.66 nM) and 20-fold or gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::764fb6e2b02cfb840ab821357478eae6
https://pubmed.ncbi.nlm.nih.gov/10900249
https://pubmed.ncbi.nlm.nih.gov/10900249
Publikováno v:
Cellular signalling. 11(6)
Muscarinic agonists stimulated arachidonic acid release from 10- to 32-fold in Chinese hamster ovary (CHO) cells transfected with muscarinic M1, M3 and M5 receptor subtypes. Muscarinic agonists liberated arachidonic acid from the cAMP-coupled M2 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::027595d6bf7b6d7f339d838a7d7e39d9
https://pubmed.ncbi.nlm.nih.gov/10400314
https://pubmed.ncbi.nlm.nih.gov/10400314
Publikováno v:
The British journal of psychiatry. Supplement. (37)
Olanzapine, an atypical antipsychotic, has a broad receptor binding profile, which may account for its pharmacological effects in schizophrenia. In vitro receptor binding studies showed a high affinity for dopamine D2, D3, and D4 receptors; all 5-HT2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1874d27da26834dbfe92a9130993b62f
https://pubmed.ncbi.nlm.nih.gov/10211140
https://pubmed.ncbi.nlm.nih.gov/10211140
Autor:
M D, Swedberg, M J, Sheardown, P, Sauerberg, P H, Olesen, P D, Suzdak, K T, Hansen, F P, Bymaster, J S, Ward, C H, Mitch, D O, Calligaro, N W, Delapp, H E, Shannon
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 281(2)
Butylthio[2.2.2] ((+)-(S)-3-(4-(Butylthio)-1,2,5-thiadiazol-3-yl)-1-azabicyclo[2.2. 2] octane) is an agonist/antagonist at muscarinic receptors. The analgesic potential of butylthio[2.2.2] was assessed in the mouse by use of the grid-shock, tail-flic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6f53abf6a2ac73b4b6897589c371673a
https://pubmed.ncbi.nlm.nih.gov/9152397
https://pubmed.ncbi.nlm.nih.gov/9152397
Autor:
H E, Shannon, M J, Sheardown, F P, Bymaster, D O, Calligaro, N W, Delapp, J, Gidda, C H, Mitch, B D, Sawyer, P W, Stengel, J S, Ward, D T, Wong, P H, Olesen, P D, Suzdak, P, Sauerberg, M D, Swedberg
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 281(2)
Butylthio[2.2.2], ((+)-(S)-3-(4-butylthio-1,2,5-thiadiazol-3-yl)-1-azabicyclo[2.2.2] octane; LY297802/NNC11-1053) is a muscarinic receptor ligand which is equiefficacious to morphine in producing antinociception. In vitro, butylthio[2.2.2] had high a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::60ea834b475d911247439bbb12b0e68f
https://pubmed.ncbi.nlm.nih.gov/9152398
https://pubmed.ncbi.nlm.nih.gov/9152398
Publikováno v:
The Journal of clinical psychiatry. 58
Classical (typical) antipsychotic drugs are in wide use clinically, but some patients do not respond at all to treatment, while in others, negative symptoms and cognitive deficits fail to respond. Also, these drugs often cause serious motor disturban
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d47ce3ac9baac8f7af2dccbc6c8be439
https://pubmed.ncbi.nlm.nih.gov/9265914
https://pubmed.ncbi.nlm.nih.gov/9265914
Autor:
C. H. Mitch, F. P. Bymaster, D. O. Calligaro, S. J. Quimby, B. D. Sawyer, H. E. Shannon, J. S. Ward, P. H. Olesen, P. Sauerberg, M. J. Sheardown, P. D. Suzdak, Novo Nordisk
Publikováno v:
Alzheimer’s and Parkinson’s Diseases ISBN: 9781475791471
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01a4252f01f408f12e8bd1dde0525080
https://doi.org/10.1007/978-1-4757-9145-7_66
https://doi.org/10.1007/978-1-4757-9145-7_66
Autor:
M M, Foreman, R W, Fuller, K, Rasmussen, D L, Nelson, D O, Calligaro, L, Zhang, J E, Barrett, R N, Booher, C J, Paget, M E, Flaugh
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 270(3)
(-)-LY293284, (-)-4R-6-acetyl-4-(di-n-propylamino)1,3,4,5- tetrahydrobenz[c,d]indole, is a conformationally restricted tryptamine derivative with an acetyl group serving as a protophilic substitution for the hydroxyl in serotonin (5-HT). In ligand di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::035d86dbfa5f52669558b92e14458821
https://pubmed.ncbi.nlm.nih.gov/7523657
https://pubmed.ncbi.nlm.nih.gov/7523657
Autor:
F P, Bymaster, D T, Wong, C H, Mitch, J S, Ward, D O, Calligaro, D D, Schoepp, H E, Shannon, M J, Sheardown, P H, Olesen, P D, Suzdak, M D, Swedberg, P, Sauerberg
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 269(1)
Xanomeline [3(3-hexyloxy-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-me thylpyridine)] was evaluated in vivo in rat brain for effects on neurotransmitter turnover and inhibition of ex vivo binding of muscarinic radioligands. Xanomeline produced dose-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2e8c73d70d4629e175bfdcb422cedb42
https://pubmed.ncbi.nlm.nih.gov/7909558
https://pubmed.ncbi.nlm.nih.gov/7909558