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GPV is a marker of in vivo platelet activation--study in a rat thrombosis model

Autor: C, Ravanat, M, Freund, P, Mangin, D O, Azorsa, C, Schwartz, S, Moog, S, Schuhler, J, Dambach, J P, Cazenave, F, Lanza

Publikováno v: Thrombosis and haemostasis. 83(2)

Thrombin plays a central role in the genesis of thrombotic events and is the most potent known platelet agonist. This enzyme activates platelets by cleaving G-protein coupled protease activated receptors (PARs) and by binding to glycoprotein (GP) Ib.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0991d58f48abd074b8d6321b86a1a7e5
https://pubmed.ncbi.nlm.nih.gov/10739394

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Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage

Autor: C, Ravanat, M, Morales, D O, Azorsa, S, Moog, S, Schuhler, P, Grunert, D, Loew, A, Van Dorsselaer, J P, Cazenave, F, Lanza

Publikováno v: Blood. 89(9)

Platelet glycoprotein (GP) V is a major surface protein cleaved during thrombin-induced platelet activation. GPV associates noncovalently with the GPIb-IX complex to form GPIb-V-IX, a receptor for von Willebrand factor and thrombin. We describe the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03a16838ab81f5c150cd6bf10aceea35
https://pubmed.ncbi.nlm.nih.gov/9129030

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CD63/Pltgp40: a platelet activation antigen identical to the stage-specific, melanoma-associated antigen ME491

Autor: D O, Azorsa, J A, Hyman, J E, Hildreth

Publikováno v: Blood. 78(2)

CD63 is a 53-Kd lysosomal membrane glycoprotein that has been identified as a platelet activation molecule. The current study presents evidence that CD63 and Pltgp40, a platelet membrane glycoprotein identified in this laboratory, are the same molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d5f29a13d63b54a7b15cef744252eee3
https://pubmed.ncbi.nlm.nih.gov/2070066

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Characterization of a novel self-associating Mr 40,000 platelet glycoprotein

Autor: J E, Hildreth, D, Derr, D O, Azorsa

Publikováno v: Blood. 77(1)

A novel platelet glycoprotein has been purified and characterized. This glycoprotein, designated Pltgp40, is an acidic sialylated 40,000-dalton protein that bears both O-linked and N-linked oligosaccharides. Treatment of Pltgp40 with neuraminidase re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a10dcf7c7f1e81a0bfe374633c12ee51
https://pubmed.ncbi.nlm.nih.gov/1741815

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