Zobrazeno 1 - 10
of 247
pro vyhledávání: '"D O'Flanagan"'
Autor:
Brandon J. Burbach, Stephen D. O’Flanagan, Qi Shao, Katharine M. Young, Joseph R. Slaughter, Meagan R. Rollins, Tami Jo L. Street, Victoria E. Granger, Lalit. K. Beura, Samira M. Azarin, Satish Ramadhyani, Bruce R. Forsyth, John C. Bischof, Yoji Shimizu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Irreversible electroporation (IRE), a soft-tissue ablation technique used for tumour ablation, has been suggested to promote systemic immune responses. Here the authors show that IRE, followed by anti-CTLA-4 blockade, elicits the expansion of tumor a
Externí odkaz:
https://doaj.org/article/ea3da0e70d734be09e22818a11a9695a
Autor:
Emily N Truckenbrod, Kristina S Burrack, Todd P Knutson, Henrique Borges da Silva, Katharine E Block, Stephen D O'Flanagan, Katie R Stagliano, Arthur A Hurwitz, Ross B Fulton, Kristin R Renkema, Stephen C Jameson
Publikováno v:
eLife, Vol 10 (2021)
Self-specific CD8+T cells can escape clonal deletion, but the properties and capabilities of such cells in a physiological setting are unclear. We characterized polyclonal CD8+ T cells specific for the melanocyte antigen tyrosinase-related protein 2
Externí odkaz:
https://doaj.org/article/ff7be6cef5c744868a9f63397d655dc6
Autor:
Marco Künzli, Stephen D. O’Flanagan, Madeleine LaRue, Poulami Talukder, Thamotharampillai Dileepan, Andrew G. Soerens, Clare F. Quarnstrom, Sathi Wijeyesinghe, Yanqi Ye, Justine McPartlan, Jason S. Mitchell, Christian W. Mandl, Richard Vile, Marc K. Jenkins, Rafi Ahmed, Vaiva Vezys, Jasdave Chahal, David Masopust
Respiratory tract resident memory T cells (Trm), typically generated by local vaccination or infection, can accelerate control of pulmonary infections that evade neutralizing antibody. It is unknown whether mRNA vaccination establishes respiratory Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::959e5f9e405bb7978a3afd9fcfa18887
https://doi.org/10.1101/2022.06.02.494574
https://doi.org/10.1101/2022.06.02.494574
Autor:
John C. Bischof, Lalit K. Beura, Joseph R. Slaughter, Satish Ramadhyani, Stephen D O'Flanagan, Katharine M. Young, Brandon J. Burbach, Qi Shao, Victoria E. Granger, Samira M. Azarin, Tami Jo L. Street, Bruce R. Forsyth, Yoji Shimizu, Meagan R. Rollins
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Memory CD8+ T cells populate non-lymphoid tissues (NLTs) following pathogen infection, but little is known about the establishment of endogenous tumor-specific tissue-resident memory T cells (TRM) during cancer immunotherapy. Using a transplantable m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a7ded570a20f7b4bfb51a407dc3d1e
https://doi.org/10.1038/s41467-021-24132-6
https://doi.org/10.1038/s41467-021-24132-6
Autor:
Vineet Joag, Stephen D O'Flanagan, Joshua M. Thiede, Clare F. Quarnstrom, Clayton K. Mickelson, Marc K. Jenkins, J. Michael Stolley, William E. Matchett, Tyler D. Bold, David Masopust, Michelle N Vu, Vaiva Vezys, Frances K. Shepherd, Vineet D. Menachery, Jennifer A Walter, Samuel Becker, Sathi Wijeyesinghe, Ryan A. Langlois, Eyob Weyu, Andrew G. Soerens
Publikováno v:
bioRxiv
J Immunol
J Immunol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. Neutralizing Abs target the receptor binding domain of the spike (S) protein, a focus of successful vaccine efforts. Concerns have arisen that S-sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c205ab28b707a597b35f7b87b967bd
https://pubmed.ncbi.nlm.nih.gov/33948591
https://pubmed.ncbi.nlm.nih.gov/33948591
Autor:
Stephen D O'Flanagan, Ross B. Fulton, Todd P. Knutson, Kristina S. Burrack, Katharine E. Block, Emily N Truckenbrod, Kristin R Renkema, Katie R Stagliano, Stephen C. Jameson, Arthur A Hurwitz, Henrique Borges da Silva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09207ad9162a468bc80dd8f526cbf1a1
https://doi.org/10.7554/elife.65615.sa2
https://doi.org/10.7554/elife.65615.sa2
Autor:
J. Michael Stolley, Peter J. Southern, Siddheshvar Bhela, Thamotharampillai Dileepan, Maxim C.-J. Cheeran, Vineet Joag, Marc K. Jenkins, Sathi Wijeyesinghe, Joshua M. Thiede, Luca Schifanella, Jules A. Sangala, Clare F. Quarnstrom, Geoffrey T. Hart, Stephen D O'Flanagan, Sung-Wook Hong, Venkatramana D. Krishna, William E. Matchett, Noah V. Gavil, David Masopust, Sailaja Gangadhara, Tyler D. Bold, Eyob Weyu, Ryan A. Langlois, Vaiva Vezys, Rama Rao Amara, Andrew G. Soerens
Publikováno v:
J Immunol
The magnitude of SARS-CoV-2–specific T cell responses correlates inversely with human disease severity, suggesting T cell involvement in primary control. Whereas many COVID-19 vaccines focus on establishing humoral immunity to viral spike protein,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dea03208cbb13c98035ec2035630766
https://pubmed.ncbi.nlm.nih.gov/33441437
https://pubmed.ncbi.nlm.nih.gov/33441437
Autor:
Emily N, Truckenbrod, Kristina S, Burrack, Todd P, Knutson, Henrique, Borges da Silva, Katharine E, Block, Stephen D, O'Flanagan, Katie R, Stagliano, Arthur A, Hurwitz, Ross B, Fulton, Kristin R, Renkema, Stephen C, Jameson
Publikováno v:
eLife
Self-specific CD8+T cells can escape clonal deletion, but the properties and capabilities of such cells in a physiological setting are unclear. We characterized polyclonal CD8+ T cells specific for the melanocyte antigen tyrosinase-related protein 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f506dc5645dfccbd68745b4dc418bd0a
https://pubmed.ncbi.nlm.nih.gov/33929324
https://pubmed.ncbi.nlm.nih.gov/33929324
Autor:
Jolita Mereckiene, Mary Cafferkey, Martha McElligott, S. Murchan, D O'Flanagan, Suzanne Cotter, M Fitzgerald, I. Vickers, Robert Cunney, Mary Corcoran, Hilary Humphreys
Publikováno v:
Epidemiol Infect
SUMMARYThe 7 and 13-valent pneumococcal conjugate vaccines (PCVs) have reduced the incidence of invasive pneumococcal disease (IPD) in children in many countries. The objective of this work was to assess the impact of PCVs and potential herd-protecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121dbd4d6302924b4b3b94ad08cad7dd
https://doi.org/10.1017/s0950268817001194
https://doi.org/10.1017/s0950268817001194
Autor:
Abby M. Silbaugh, Samira M. Azarin, Stephen D O'Flanagan, Francisco Pelaez, Hak Rae Lee, John C. Bischof, Tiffany Lam, Qi Shao, Pegah Ranjbartehrani
Publikováno v:
Annals of biomedical engineering. 48(4)
Irreversible electroporation (IRE) is an emerging technology for non-thermal ablation of solid tumors. This study sought to integrate electrodes into microporous poly(caprolactone) (PCL) scaffolds previously shown to recruit metastasizing cancer cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb82853a0550502f1137fb9b63707efa
https://pubmed.ncbi.nlm.nih.gov/31916125
https://pubmed.ncbi.nlm.nih.gov/31916125