Zobrazeno 1 - 10
of 77
pro vyhledávání: '"D O'Day"'
Autor:
A Alghadeer, S Hanson-Drury, D Ehnes, YT Zhao, AP Patni, D O’Day, CH Spurrell, AA Gogate, A Phal, H Zhang, A Devi, Y Wang, L Starita, D Doherty, I Glass, J Shendure, D Baker, MC Regier, J Mathieu, H Ruohola-Baker
Tooth enamel secreted by ameloblasts is the hardest material in the human body, acting as a shield protecting the teeth. However, the enamel is gradually damaged or partially lost in over 90% of adults and cannot be regenerated due to a lack of amelo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25f2862a8f66fe6c67ea0338aa32e5e9
https://doi.org/10.1101/2022.08.09.503399
https://doi.org/10.1101/2022.08.09.503399
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Joel C. Barrish, David J. Shuster, Chunjian Liu, Kim W. McIntyre, Tai-An Lin, Amrita Kamath, Becky Penhallow, Kathleen D. O'Day, Steven B. Kanner, Joseph A. Furch, John H. Dodd, Steven H. Spergel, Hongjian Zhang, James Lin, Robert V. Moquin, Arthur M. Doweyko, John Wityak, Punit Marathe, Jagabandhu Das, Chen Yi Hung
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3706-3712
A series of structurally novel aminothiazole based small molecule inhibitors of Itk were prepared to elucidate their structure-activity relationships (SARs), selectivity, and cell activity in inhibiting IL-2 secretion in a Jurkat T-cell assay. Compou
Autor:
Juan J. Perez-Villar, Tai-An Lin, Gena S. Whitney, Kathleen D. O'Day, Srividhya Venkatesan, Gary L. Schieven, Robert J. Dunn, Mitchell Sitnick, Steven B. Kanner
Publikováno v:
Biochemistry. 41:10732-10740
The linker for activation of T-cells (LAT) is a palmitoylated integral membrane adaptor protein that resides in lipid membrane rafts and contains nine consensus putative tyrosine phosphorylation sites, several of which have been shown to serve as SH2
Publikováno v:
European Journal of Immunology. 30:2378-2387
One mechanism for transducing signals downstream of lymphocyte receptor activation involves the stable association between signaling proteins. To identify protein ligands of the signal activator phospholipase Cgamma1 (PLCgamma1), we screened T cell c
Autor:
D. O'Day
Publikováno v:
IEEE Software. 15:72-75
Comparing the improvement of existing software development processes to fixing up an old house, the author argues that working on one item at a time can be more practical than starting from the ground up. The author works at a software company that h
Autor:
Jagabandhu, Das, Chunjian, Liu, Robert V, Moquin, James, Lin, Joseph A, Furch, Steven H, Spergel, Arthur M, Doweyko, Kim W, McIntyre, David J, Shuster, Kathleen D, O'Day, Becky, Penhallow, Chen-Yi, Hung, Steven B, Kanner, Tai-An, Lin, John H, Dodd, Joel C, Barrish, John, Wityak
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(9)
A series of structurally novel aminothiazole based small molecule inhibitors of Itk were prepared to elucidate their structure-activity relationships (SARs), selectivity and cell activity in inhibiting IL-2 secretion in a Jurkat T-cell assay. Compoun
Autor:
Steven B. Kanner, Steven H. Spergel, Kim W. McIntyre, Robert M. Townsend, Gena S. Whitney, Robert V. Moquin, David J. Shuster, Joel C. Barrish, Juan J. Perez-Villar, Chunjian Liu, Amrita Kamath, Loran Killar, John H. Dodd, Jagabandhu Das, Xiao Xia Yang, John Wityak, Chen Yi Hung, Jennifer Postelnek, Tai-An Lin, Kathleen D. O'Day, Joseph A. Furch, Hongjian Zhang, Punit Marathe, Becky Penhallow, Arthur M. Doweyko, James Lin
Publikováno v:
Biochemistry. 43(34)
Nonreceptor protein tyrosine kinases including Lck, ZAP-70, and Itk play essential roles in T-cell receptor (TCR) signaling. Gene knockout studies have revealed that mice lacking these individual kinases exhibit various degrees of immunodeficiency; h
Autor:
Juan J. Perez-Villar, Steven G. Nadler, Kathleen D. O'Day, Derek H. Hewgill, Steven B. Kanner
Publikováno v:
International immunology. 13(10)
We report a physical and functional association between the Tec-family tyrosine kinase Itk (Emt/Tsk) and the nuclear import chaperone karyopherin alpha (Rch1alpha) in human T cells. The Itk-SH3 domain and the Rch1alpha proline-rich (PR) motif were cr