Zobrazeno 1 - 10 of 51 pro vyhledávání: '"D N, Brindley"'
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Effects of benfluore× on serum triacylglycerols and insulin sensitivity in the corpulent rat
Autor: James C. Russell, P J Dolphin, Sandra E. Graham, D N Brindley
Publikováno v: Canadian Journal of Physiology and Pharmacology. 74:879-886
The JCR:LAncp rat is obese, insulin resistant, and hyperlipidemic, and the males develop atherosclerosis and ischemic myocardial disease. Benfluorex at 35n40 mg·kg n1 body weight was administered in the food from 10 to 14 weeks of age and resulted i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3456cf5e0f04b6b97895a3361f2f9d7c
https://doi.org/10.1139/cjpp-74-8-879
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6
Co-ordinate regulation of growth factor receptors and lipid phosphate phosphatase-1 controls cell activation by exogenous lysophosphatidate
Autor: C, Pilquil, Z C, Ling, I, Singh, K, Buri, Q X, Zhang, D N, Brindley
Publikováno v: Biochemical Society transactions. 29(Pt 6)
The serum-derived lipid growth factors, lysophosphatidate (LPA) and sphingosine 1-phosphate (S1P), activate cells selectively through different members of a family of endothelial differentiation gene (EDG) receptors. Activation of EDG receptors by LP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::95a9eb46da9bf49b98f2b1463746bf29
https://pubmed.ncbi.nlm.nih.gov/11709082
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7
Beneficial insulin-sensitizing and vascular effects of S15261 in the insulin-resistant JCR:LA-cp rat
Autor: J C, Russell, D, Ravel, J P, Pégorier, P, Delrat, R, Jochemsen, S F, O'Brien, S E, Kelly, S T, Davidge, D N, Brindley
Publikováno v: The Journal of pharmacology and experimental therapeutics. 295(2)
S15261, a compound developed for the oral treatment of type II diabetes, is cleaved by esterases to the fragments Y415 and S15511. The aim was to define the insulin-sensitizing effects of S15261, the cleavage products, and troglitazone and metformin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::93b70e14a0c28786c82572a43acaf9c1
https://pubmed.ncbi.nlm.nih.gov/11046115
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9
Induction of endothelial monolayer permeability by phosphatidate
Autor: D, English, Y, Cui, R, Siddiqui, C, Patterson, V, Natarajan, D N, Brindley, J G, Garcia
Publikováno v: Journal of cellular biochemistry. 75(1)
Released into the vasculature from disrupted cells or transported to the surface of adjacent effectors, phosphatidate and related lipids may potentiate endothelial cell activation. However, the effect of these lipids on endothelial monolayer barrier
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::938d959bc51852d18de624f53421ea16
https://pubmed.ncbi.nlm.nih.gov/10462709
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10
Epidermal growth factor inhibits ceramide-induced apoptosis and lowers ceramide levels in primary placental trophoblasts
Autor: S G, Payne, D N, Brindley, L J, Guilbert
Publikováno v: Journal of cellular physiology. 180(2)
The activation of sphingomyelinase and the subsequent generation of ceramide are emerging as important components of signaling pathways leading to apoptosis. The combination of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::416d69bcfde1bd45619285db75a2e28c
https://pubmed.ncbi.nlm.nih.gov/10395296
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