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Autor:
Meng-Jung Chiang, Faik N Musayev, Martina Kosikova, Zhengshi Lin, Yamei Gao, Philip D Mosier, Bashayer Althufairi, Zhiping Ye, Qibing Zhou, Umesh R Desai, Hang Xie, Martin K Safo
Publikováno v:
Emerging Microbes and Infections, Vol 6, Iss 1, Pp 1-11 (2017)
The M gene segment of influenza A virus has been shown to be a contributing factor to the high growth phenotype. However, it remains largely unknown why matrix protein 1 (M1), the major structural protein encoded by M gene, exhibits pH-dependent conf
Externí odkaz:
https://doaj.org/article/012e972efd224b868ea35d92c5d90cd6
Autor:
Irina Etobayeva, Sara B. Linden, Farhang Alem, Laith Harb, Lucas Rizkalla, Philip D. Mosier, Allison A. Johnson, Louise Temple, Ramin M. Hakami, Daniel C. Nelson
Publikováno v:
Viruses, Vol 10, Iss 5, p 276 (2018)
Three Bacillus bacteriophage-derived endolysins, designated PlyP56, PlyN74, and PlyTB40, were identified, cloned, purified, and characterized for their antimicrobial properties. Sequence alignment reveals these endolysins have an N-terminal enzymatic
Externí odkaz:
https://doaj.org/article/da4e3e0d67904a55911195bf81045323
Autor:
Francesca S, Abatematteo, Philip D, Mosier, Mauro, Niso, Leonardo, Brunetti, Francesco, Berardi, Fulvio, Loiodice, Marialessandra, Contino, Benjamin, Delprat, Tangui, Maurice, Antonio, Laghezza, Carmen, Abate
Publikováno v:
European journal of medicinal chemistry. 228
The sigma-1 (σ
Autor:
Giuseppe Gasparre, Marcello Leopoldo, Carmen Abate, Savina Ferorelli, Francesco Berardi, Giuseppe Cassano, Roberta Marottoli, Mauro Niso, Philip D. Mosier
Publikováno v:
Future Medicinal Chemistry. 11:2547-2562
Aim: The σ1 receptor is a druggable target involved in many physiological processes and diseases. To clarify its physiology and derive therapeutic benefit, nine analogs based on the σ1 antagonist PB212 were synthesized replacing the 4-methylpiperid
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109510 (2014)
Matrix protein 1 (M1) of the influenza A virus plays multiple roles in virion assembly and infection. Interest in the pH dependence of M1's multiple functions led us to study the effect of subtle pH changes on M1 structure, resulting in the elucidati
Externí odkaz:
https://doaj.org/article/fffd62a16ceb459b9bf81f3aab59f1b6
Autor:
Richard D. Mosier
The American Temper: Patterns of Our Intellectual Heritage explores the evolution of American intellectual thought through four major movements—Puritanism, Republicanism, Transcendentalism, and Pragmatism—each contributing distinctively to the Am
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48632 (2012)
The antithrombin-heparin/heparan sulfate (H/HS) and thrombin-H/HS interactions are recognized as prototypic specific and non-specific glycosaminoglycan (GAG)-protein interactions, respectively. The fundamental structural basis for the origin of speci
Externí odkaz:
https://doaj.org/article/d33788b9c3f544ec9e9f9a78132156d4
Autor:
Michael M. White, Osama I. Alwassil, Marvin K. Schulte, Shailesh Khatri, Ahmed S. Abdelkhalek, Heather L. Nyce, Genevieve S Alley, Malgorzata Dukat, Philip D. Mosier
Publikováno v:
ACS Chemical Neuroscience. 10:1380-1389
Arylguanidines, depending upon their aromatic substitution pattern, display varying actions at 5-HT3 receptors (e.g., partial agonist, agonist, superagonist). Here, we demonstrate that conformational constraint of these agents as dihydroquinazolines