Zobrazeno 1 - 10
of 88
pro vyhledávání: '"D Michiel, Pegtel"'
Autor:
Norbert Moldovan, Sandra Verkuijlen, Ymke van der Pol, Leontien Bosch, Jan R.T. van Weering, Idris Bahce, D. Michiel Pegtel, Florent Mouliere
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110742- (2024)
Summary: Blood contains multiple analytes that can be used as liquid biopsy to analyze cancer. Mutations have been detected in DNA associated with small extracellular vesicles (sEVs). The genome-wide composition and structure of sEV DNA remains poorl
Externí odkaz:
https://doaj.org/article/5f34ee0e26cb412d835d0c29a2af68ee
Autor:
Esther E. E. Drees, Nils J. Groenewegen, Sandra A. W. M. Verkuijlen, Monique A. J. vanEijndhoven, Jip Ramaker, Pepijn Veenstra, Mirjam Hussain, Catharina G. M. Groothuis‐Oudshoorn, Daphne deJong, Josée M. Zijlstra, Johan deRooij, D. Michiel Pegtel
Publikováno v:
Journal of Extracellular Biology, Vol 3, Iss 7, Pp n/a-n/a (2024)
Abstract Previously, we showed that quantification of lymphoma‐associated miRNAs miR‐155‐5p, ‐127‐3p and let‐7a‐5p levels in plasma extracellular vesicles (EVs) report treatment response in patients with classic Hodgkin lymphoma (cHL).
Externí odkaz:
https://doaj.org/article/61f123c0de464cf2954835bebd3965e3
Autor:
Ymke van der Pol, Normastuti Adhini Tantyo, Nils Evander, Anouk E Hentschel, Birgit MM Wever, Jip Ramaker, Sanne Bootsma, Marieke F Fransen, Kristiaan J Lenos, Louis Vermeulen, Famke L Schneiders, Idris Bahce, Jakko A Nieuwenhuijzen, Renske DM Steenbergen, D Michiel Pegtel, Norbert Moldovan, Florent Mouliere
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp 1-10 (2023)
Abstract Cell‐free DNA (cfDNA) can be isolated and sequenced from blood and/or urine of cancer patients. Conventional short‐read sequencing lacks deployability and speed and can be biased for short cfDNA fragments. Here, we demonstrate that with
Externí odkaz:
https://doaj.org/article/b680ea20f07b4e7887161c9b62d150f1
Autor:
Ymke van der Pol, Norbert Moldovan, Jip Ramaker, Sanne Bootsma, Kristiaan J. Lenos, Louis Vermeulen, Shahneen Sandhu, Idris Bahce, D. Michiel Pegtel, Stephen Q. Wong, Sarah-Jane Dawson, Dineika Chandrananda, Florent Mouliere
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background Existing methods to detect tumor signal in liquid biopsy have focused on the analysis of nuclear cell-free DNA (cfDNA). However, non-nuclear cfDNA and in particular mitochondrial DNA (mtDNA) has been understudied. We hypothesize t
Externí odkaz:
https://doaj.org/article/f391dac559774ebc9fe41ed580f121ff
Autor:
Monique A.J. van Eijndhoven, Chantal Scheepbouwer, Ernesto Aparicio-Puerta, Michael Hackenberg, D. Michiel Pegtel
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102645- (2023)
Summary: Besides canonical microRNAs (miRNAs), sequence-based variations called isomiRs have biological relevance and diagnostic potential; however, accurate calling of these post-transcriptional modifications is challenging, especially for low input
Externí odkaz:
https://doaj.org/article/f333a2f9af6b43af94de6e9a12fc66dd
Autor:
Maarten P. Bebelman, Irfan M. Setiawan, Nick D. Bergkamp, Jeffrey R. van Senten, Caitrin Crudden, Jan Paul M. Bebelman, Frederik J. Verweij, Guillaume van Niel, Marco Siderius, D. Michiel Pegtel, Martine J. Smit
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107412- (2023)
Summary: The human cytomegalovirus (HCMV)-encoded chemokine receptor US28 contributes to various aspects of the viral life cycle and promotes immune evasion by scavenging chemokines from the microenvironment of HCMV-infected cells. In contrast to the
Externí odkaz:
https://doaj.org/article/3584ed7d87864108bd8d9bb36453dd90
Autor:
Jillian W. P. Bracht, Mandy Los, Monique A. J. vanEijndhoven, Britta Bettin, Edwin van derPol, D. Michiel Pegtel, Rienk Nieuwland
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 2, Pp n/a-n/a (2023)
Abstract Human blood plasma prepared by centrifugation contains not only extracellular vesicles (EVs) but also platelets and erythrocyte ghosts (ery‐ghosts). Here we studied whether analysis of miRNA associated with plasma EVs (EV‐miRNA) is affec
Externí odkaz:
https://doaj.org/article/afd33b2016914a7080d23cc0a7d545e8
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 149-157 (2021)
The discovery that cancer cells discharge vast quantities of extracellular vesicles (EVs), underscored the explosion of the EV field. A large body of evidence now supports their onco-functionality in an array of contexts; stromal crosstalk, immune ev
Externí odkaz:
https://doaj.org/article/db00166357514548ab2a9dd0df744731
Autor:
Tereza Brachtlova, Jan-Willem van Ginkel, Mark J. Luinenburg, Renée X. de Menezes, Danijela Koppers-Lalic, D. Michiel Pegtel, Wenliang Dong, Tanja D. de Gruijl, Victor W. van Beusechem
Publikováno v:
Molecular Therapy: Oncolytics, Vol 19, Iss , Pp 332-343 (2020)
Oncolytic adenoviruses are being developed as new anti-cancer agents. Their efficacy can be improved by incorporating RNA interference (RNAi) molecules. RNAi molecules can be expressed in various precursor formats. The aim of this study was to determ
Externí odkaz:
https://doaj.org/article/1aaae3dbac784368bbd487059385b756
Autor:
Esther E. E. Drees, Margaretha G. M. Roemer, Nils J. Groenewegen, Jennifer Perez‐Boza, Monique A. J. vanEijndhoven, Leah I. Prins, Sandra A. W. M. Verkuijlen, Xuan‐Mai Tran, Julia Driessen, G. J. C. Zwezerijnen, Phylicia Stathi, Kevin Mol, Joey J. J. P. Karregat, Aikaterini Kalantidou, Andrea Vallés‐Martí, T. J. Molenaar, Ernesto Aparicio‐Puerta, Erik vanDijk, Bauke Ylstra, Catharina G. M. Groothuis‐Oudshoorn, Michael Hackenberg, Daphne deJong, Josée M. Zijlstra, D. Michiel Pegtel
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 9, Pp n/a-n/a (2021)
Abstract Minimally‐invasive tools to assess tumour presence and burden may improve clinical management. FDG‐PET (metabolic) imaging is the current gold standard for interim response assessment in patients with classical Hodgkin Lymphoma (cHL), bu
Externí odkaz:
https://doaj.org/article/dd7ff80e47294223ac9069d292d8a4bd