Zobrazeno 1 - 9
of 9
pro vyhledávání: '"D Michele Nikoloff"'
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131497 (2015)
The p53 tumor suppressor gene (TP53) is reported to be mutated in nearly half of all tumors and plays a central role in genome integrity. Detection of mutations in p53 can be accomplished by many assays, including the AmpliChip p53 Research Test. The
Externí odkaz:
https://doaj.org/article/0a256f9472b34d50842222be7dddf4af
Autor:
Jose de Leon, Alison Shao, Mike Hardin, D. Michele Nikoloff, Margaret T. Susce, Grantland Hillman, Antonette C.P. Allen, Francis A. Chiafari, Maria Johnson, Lorraine Maw
Publikováno v:
CNS Spectrums. 14:19-35
Introduction:An important technological advance in genetic testing is the DNA microarray, which allows for the simultaneous testing of thousands of DNA sequences. The AmpliChip CYP450 Test employs this microarray technology for cytochrome P450 (CYP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f1ea956d8d24efd9518dde9923484f6
https://doi.org/10.1017/s1092852900020022
https://doi.org/10.1017/s1092852900020022
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 6, p e0131497 (2015)
PLoS ONE, Vol 10, Iss 6, p e0131497 (2015)
The p53 tumor suppressor gene (TP53) is reported to be mutated in nearly half of all tumors and plays a central role in genome integrity. Detection of mutations in p53 can be accomplished by many assays, including the AmpliChip p53 Research Test. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc7f801f769cb4a37f51c402e7ad0f1
http://europepmc.org/articles/PMC4488390
http://europepmc.org/articles/PMC4488390
Autor:
Keith A. Candiotti, David M. Andrews, Fani Nhuch, David A. Lubarsky, Lin Wu, Aimee Kamat, David J. Birnbach, D. Michele Nikoloff, Walter H. Koch
Publikováno v:
Anesthesiology. 102:543-549
Background Some patients treated with ondansetron for postoperative nausea and vomiting do not respond to therapy. One possible mechanism for this failure is ultrarapid drug metabolism via the cytochrome P-450 system, specifically the enzyme 2D6 (CYP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50f6c7fb68ee56ec68a2c3f6599acdee
https://doi.org/10.1097/00000542-200503000-00011
https://doi.org/10.1097/00000542-200503000-00011
Autor:
D. Michele Nikoloff, Marcel Fontecha, Jack Cuzick, John F. Forbes, Anthony Howell, Roseann Kealy, Ivana Sestak
Publikováno v:
British Journal of Cancer
Background: Several studies have reported discordant results regarding the impact of the CYP2D6 phenotype on both the effectiveness and the degree of endocrine symptoms associated with tamoxifen. Other studies have suggested that menopausal symptoms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::560740eb2cd6c917d22a3e92b285d20c
https://pubmed.ncbi.nlm.nih.gov/22735900
https://pubmed.ncbi.nlm.nih.gov/22735900
Autor:
D. Michele Nikoloff, Alastair M. Thompson, Kirsten D. Hadfield, Anthony Howell, William G. Newman, Lee B. Jordan, Grantland Hillman, Susan E. Bray, Andrea Johnson, D. Gareth Evans, Ayshe Latif, Philip R. Quinlan, Jeffrey Lawrence, Colin A. Purdie, Roberta Ferraldeschi, Robert Clarke, Marcel Fontecha, Linda Ashcroft
Publikováno v:
Breast cancer research and treatment. 125(1)
The association between CYP2D6 genotype and outcome in breast cancer patients treated with adjuvant tamoxifen remains controversial. We assessed the influence of comprehensive versus limited CYP2D6 genotype in the context of tamoxifen adherence and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e556bf11b9a8d6b1c170e35b67d0c03a
https://pubmed.ncbi.nlm.nih.gov/20809362
https://pubmed.ncbi.nlm.nih.gov/20809362
Autor:
Y. Jin, Anne Nguyen, S. Borges, Vered Stearns, David A. Flockhart, Grant Hillman, Daniel F. Hayes, Bryan A. Ward, Zeruesenay Desta, Lin Wu, Todd C. Skaar, D. Michele Nikoloff, Lang Li, Anna Maria Storniolo
Publikováno v:
Clinical pharmacology and therapeutics. 80(1)
Background and Objectives N-Desmethyltamoxifen (NDM), a major primary metabolite of tamoxifen, is hydroxylated by cytochrome P450 (CYP) 2D6 to yield endoxifen. Because of its high antiestrogenic potency, endoxifen may play an important role in the cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b49f944a8410983649d7fbf4922cbc
https://pubmed.ncbi.nlm.nih.gov/17245346
https://pubmed.ncbi.nlm.nih.gov/17245346
Autor:
Teri Melese, H. Jeffrey Lawrence, Simone Tchu, D. Michele Nikoloff, Michelle E. Melisko, Hope S. Rugo, Elad Ziv, Alan Hb Wu, Mary S. Beattie, Wendy Lorizio
Publikováno v:
Lorizio, Wendy; Rugo, Hope; Beattie, Mary S; Tchu, Simone; Melese, Teri; Melisko, Michelle; et al.(2011). Pharmacogenetic testing affects choice of therapy among women considering tamoxifen treatment. Genome Medicine, 3(10), 64. doi: http://dx.doi.org/10.1186/gm280. Retrieved from: http://www.escholarship.org/uc/item/3m34b9p4
Genome Medicine
Genome Medicine
Background Pharmacogenetic testing holds major promise in allowing physicians to tailor therapy to patients based on genotype. However, there is little data on the impact of pharmacogenetic test results on patient and clinician choice of therapy. CYP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67b523cef36c9700bfa0e156cda2158
https://doi.org/10.1186/gm280
https://doi.org/10.1186/gm280
Autor:
D. Michele Nikoloff, John M. Lopes, Marci J. Swede, Susan A. Henry, Michael White, Sepp D. Kohlwein, Tina Gill, John A. Ambroziak, Allen Deborah J, Kimberly A. Hudak
Publikováno v:
Dynamics of Membrane Assembly ISBN: 9783662028629
Baker’s yeast, Saccharomyces cerevisiae, synthesizes its membrane phospholipids by utilizing pathways largely common to other eukaryotes (Figure 1). This simple unicellular organism can easily be manipulated using well established classical genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f67bb8e48b159046d4f849fde372c7a7
https://doi.org/10.1007/978-3-662-02860-5_3
https://doi.org/10.1007/978-3-662-02860-5_3
