Zobrazeno 1 - 10
of 152
pro vyhledávání: '"D Martin Watterson"'
Autor:
David J Braun, David K Powell, Christopher J McLouth, Saktimayee M Roy, D Martin Watterson, Linda J Van Eldik
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0262474 (2022)
Alzheimer's disease (AD) is the leading cause of dementia in the elderly, but therapeutic options are lacking. Despite long being able to effectively treat the ill-effects of pathology present in various rodent models of AD, translation of these stra
Externí odkaz:
https://doaj.org/article/dd798bd53b724afca293bc669e7513e2
Autor:
Adam D Bachstetter, Zhengqiu Zhou, Rachel K Rowe, Bin Xing, Danielle S Goulding, Alyssa N Conley, Pradoldej Sompol, Shelby Meier, Jose F Abisambra, Jonathan Lifshitz, D Martin Watterson, Linda J Van Eldik
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149451 (2016)
A prevailing neuroinflammation hypothesis is that increased production of proinflammatory cytokines contributes to progressive neuropathology, secondary to the primary damage caused by a traumatic brain injury (TBI). In support of the hypothesis, pos
Externí odkaz:
https://doaj.org/article/32ab32dac3e442338effa09f838c073e
Autor:
Adam D Bachstetter, Scott J Webster, Tao Tu, Danielle S Goulding, Jacques Haiech, D Martin Watterson, Linda J Van Eldik
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105191 (2014)
The calcium/calmodulin-dependent protein kinase II (CaMKII) is abundant in the brain, where it makes important contributions to synaptic organization and homeostasis, including playing an essential role in synaptic plasticity and memory. Four genes e
Externí odkaz:
https://doaj.org/article/476fb8c9b5584f5e8f3d8c8be28881f6
Autor:
Gerardo A Morfini, Daryl A Bosco, Hannah Brown, Rodolfo Gatto, Agnieszka Kaminska, Yuyu Song, Linda Molla, Lisa Baker, M Natalia Marangoni, Sarah Berth, Ehsan Tavassoli, Carolina Bagnato, Ashutosh Tiwari, Lawrence J Hayward, Gustavo F Pigino, D Martin Watterson, Chun-Fang Huang, Gary Banker, Robert H Brown, Scott T Brady
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65235 (2013)
Dying-back degeneration of motor neuron axons represents an established feature of familial amyotrophic lateral sclerosis (FALS) associated with superoxide dismutase 1 (SOD1) mutations, but axon-autonomous effects of pathogenic SOD1 remained undefine
Externí odkaz:
https://doaj.org/article/c19ff8f0c04447fd912d1b2f9f9ca560
Autor:
Fabeha Fazal, Kaiser M Bijli, Matthew Murrill, Antony Leonard, Mohammad Minhajuddin, Khandaker N Anwar, Jacob N Finkelstein, D Martin Watterson, Arshad Rahman
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59965 (2013)
The pathogenesis of acute lung injury (ALI) involves bidirectional cooperation and close interaction between inflammatory and coagulation pathways. A key molecule linking coagulation and inflammation is the procoagulant thrombin, a serine protease wh
Externí odkaz:
https://doaj.org/article/d8f3ce22b5924c119c65275c26be284f
Autor:
D Martin Watterson, Valerie L Grum-Tokars, Saktimayee M Roy, James P Schavocky, Brinda Desai Bradaric, Adam D Bachstetter, Bin Xing, Edgardo Dimayuga, Faisal Saeed, Hong Zhang, Agnieszka Staniszewski, Jeffrey C Pelletier, George Minasov, Wayne F Anderson, Ottavio Arancio, Linda J Van Eldik
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66226 (2013)
Serine-threonine protein kinases are critical to CNS function, yet there is a dearth of highly selective, CNS-active kinase inhibitors for in vivo investigations. Further, prevailing assumptions raise concerns about whether single kinase inhibitors c
Externí odkaz:
https://doaj.org/article/b2d92bb12d1e444bacfe050f97863231
Autor:
Michael Zimmermann, Cédric Atmanene, Qingyan Xu, Laetitia Fouillen, Alain Van Dorsselaer, Dominique Bonnet, Claire Marsol, Marcel Hibert, Sarah Sanglier-Cianferani, Claire Pigault, Laurie K McNamara, D Martin Watterson, Jacques Haiech, Marie-Claude Kilhoffer
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e14120 (2010)
Death-Associated Protein Kinase (DAPK) is a member of the Ca2+/calmodulin regulated serine/threonine protein kinases. Its biological function has been associated with induced cell death, and in vivo use of selective small molecule inhibitors of DAPK
Externí odkaz:
https://doaj.org/article/d9359a116e634e4bb98d0150476fb795
Autor:
Michael C. Schmid, Sang Won Kang, Hui Chen, Marc Paradise, Anghesom Ghebremedhin, Megan M. Kaneda, Shao-Ming Chin, Anh Do, D. Martin Watterson, Judith A. Varner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Myeloid cell recruitment during tumor inflammation depends on the VCAM-1 receptor integrin α4β1. Here the authors show that a high molecular weight form of myosin light chain kinase, MLCK210, is required for myeloid cell integrin α4β1 activation
Externí odkaz:
https://doaj.org/article/b6c618803fc74a3887178594aab67db6
Autor:
Zhengqiu Zhou, Adam D. Bachstetter, Claudia B. Späni, Saktimayee M. Roy, D. Martin Watterson, Linda J. Van Eldik
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-12 (2017)
Abstract Background Brain p38α mitogen-activated protein kinase (MAPK), a potential therapeutic target for cognitive dysfunction based on the neuroinflammation-synaptic dysfunction cycle of pathophysiology progression, offers an innovative pharmacol
Externí odkaz:
https://doaj.org/article/1b8eea9629e246129c693f9ce3e6d8d7
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1868(11)
Background Myosin light chain kinase (MLCK) is a Ca2+-calmodulin-dependent enzyme dedicated to phosphorylate and activate myosin II to provide force for various motile processes. In smooth muscle cells and many other cells, small MLCK (S-MLCK) is a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4700534b783f5a9d766c54338426a0de
https://pubmed.ncbi.nlm.nih.gov/34302892
https://pubmed.ncbi.nlm.nih.gov/34302892