Evaluation of the pharmacokinetics of prednisolone in paediatric patients with acute lymphoblastic leukaemia treated according to Dutch Childhood Oncology Group protocols and its relation to treatment response

Autor: C. Michel Zwaan, Gertjan J.L. Kaspers, Rob Pieters, Marc Bierings, Sebastiaan D. T. Sassen, D Maroeska W W Te Loo, Wim J. E. Tissing, Inge M. van der Sluis, Ron A. A. Mathôt, Valerie de Haas, Cor van den Bos

Publikováno v: British journal of haematology, 194(2), 423-432. Wiley-Blackwell
British Journal of Haematology, 194(2), 423-432. Wiley
British Journal of Haematology, 194(2), 423-432. Wiley-Blackwell Publishing Ltd
British Journal of Haematology
Sassen, S D T, Mathôt, R A A, Pieters, R, de Haas, V, Kaspers, G J L, van den Bos, C, Tissing, W J E, te Loo, D M W W, Bierings, M B, van der Sluis, I M & Zwaan, C M 2021, ' Evaluation of the pharmacokinetics of prednisolone in paediatric patients with acute lymphoblastic leukaemia treated according to Dutch Childhood Oncology Group protocols and its relation to treatment response ', British Journal of Haematology, vol. 194, no. 2, pp. 423-432 . https://doi.org/10.1111/bjh.17572
British Journal of Haematology, 194(2), 423-432. Wiley-Blackwell

Summary Glucocorticoids form the backbone of paediatric acute lymphoblastic leukaemia (ALL) treatment. Many studies have been performed on steroid resistance; however, few studies have addressed the relationship between dose, concentration and clinic

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https://pure.eur.nl/en/publications/da478205-48f0-4fe8-81b3-4b75924fdb91