Zobrazeno 1 - 10
of 24
pro vyhledávání: '"D M Van Winkle"'
Autor:
D M Van Winkle, D L Miller
Publikováno v:
Cardiovascular Research. 42:680-684
Objective: Ischemic preconditioning has been demonstrated in a wide variety of animals, from dogs to rats. Experimentally-induced murine myocardial ischemia–reperfusion has been described, but ischemic preconditioning has not been reported in mouse
Publikováno v:
Basic Research in Cardiology. 94:136-143
The hypothesis that naloxone blockade of ischemic preconditioning (IP)-induced infarct limitation does not require central nervous system participation was evaluated using quaternary naloxone in anesthetized rabbits (Study I) and naloxone hydrochlori
Autor:
G L Chien, D. M. Van Winkle
Publikováno v:
Journal of Molecular and Cellular Cardiology. 28:1895-1900
This study tested the hypothesis that endogenous opioids are involved in the infarct limitation of myocardial ischemic preconditioning (IP). Blockade of IP-induced infarct limitation by (-)naloxone hydrochloride (-NAL) or its receptor-inactive stereo
Publikováno v:
Cardiovascular Research. 30:405-412
Objectives: This study compared simultaneous regional myocardial blood flow (RMBF) measurements using fluorescent microspheres (FM) and radiolabeled microspheres (RM). The utility of an internal standard during processing was also examined. Methods:
Publikováno v:
Cardiovascular Research. 28:1574-1580
Objective: The aim was to determine whether three commonly used animal anaesthetics alter the magnitude of infarct limitation achieved with ischaemic preconditioning. Methods: Eighty four anaesthetised non-preconditioned and preconditioned open chest
Publikováno v:
Cardiovascular Research. 28:1014-1017
Objectives: This study tested the hypothesis that small changes in temperature above the hypothermic range may alter myocardial infarct size after acute coronary occlusion-reperfusion. A secondary hypothesis, that a correlation between temperature an
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 261:H500-H505
Ventricular decompression has been shown to have little effect on either the magnitude or transmural distribution of the extravascular resistance in the small hearts of the cat or rabbit. This study tests whether that independence from ventricular pr
Publikováno v:
Circulation. 84:350-356
BACKGROUND Preconditioning (5 minutes of ischemia followed by 10 minutes of recovery) renders the heart very resistant to infarction from subsequent ischemia. This study tests whether adenosine receptors might mediate preconditioning protection. METH
Publikováno v:
Circulation Research. 68:531-542
A two-part experiment was designed to test the hypothesis that myocardial oxygen and carbon dioxide tensions, as measured by coronary venous oxygen and carbon dioxide tensions, determine coronary blood flow during increases in myocardial oxygen consu
Autor:
Qin Yang, Lowell E. Davis, D M Van Winkle, A. R. Hohimer, George D. Giraud, Malcolm J. Underwood, G.-W. He
Publikováno v:
Acta physiologica (Oxford, England). 194(4)
Aims: We investigated whether chronic fetal anaemia affects myocardial infarct in adulthood and elicits functional modifications in adult coronary vasoreactivity. Methods: Seven-month-old sheep that were made anaemic in utero and transfused to normal