Zobrazeno 1 - 10
of 32
pro vyhledávání: '"D M Oh"'
Publikováno v:
The Review of scientific instruments. 91(1)
We have designed, constructed, and tested an electrical vacuum feedthrough that can carry a large number of microwave signal lines, has high vacuum compatibility, and is highly customizable. We found that it had a leak rate of approximately 10-7 Pa L
Publikováno v:
Acta Horticulturae. :71-72
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 299(2)
The proton-coupled oligopeptide transporter (PEPT1) has been shown to mediate mucosal cell transport of di- and tripeptide, and some peptidomimetic drugs. In this study, we determined the correlation between PEPT1 protein expression and the permeabil
Publikováno v:
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 238(8)
Background: Our studies had indicated that optic disc vasculitis (ODV) is a distinct clinical entity. We investigated the presentation and clinical characteristics of ODV and determined the efficacy of systemic corticosteroids in its management. Meth
Autor:
D M, Oh, G L, Amidon
Publikováno v:
Pharmaceutical biotechnology. 12
Pharmaceutical scientists increasingly utilize transporters for drug delivery and targeting. The biological barriers to drug delivery can basically be divided into epithelial, endothelial, elimination, and target cell barriers. Membrane transporters
Publikováno v:
Pharmaceutical biotechnology. 12
A wide variety of transporters are found in the intestine, and are involved in the membrane transport of daily nutrients as well as drugs. These intestinal transporters are located in the brush border membrane as well as basolateral membrane. Each tr
Publikováno v:
Journal of pharmaceutical sciences. 89(2)
This study reports the results of the combined effect of pH and surfactant on the dissolution of piroxicam (PX), an ionizable water-insoluble drug in physiological pH. The intrinsic dissolution rate (J(total)) of PX was measured in the pH range from
Autor:
N, Surendran, K M, Covitz, H, Han, W, Sadee, D M, Oh, G L, Amidon, R M, Williamson, C F, Bigge, B H, Stewart
Publikováno v:
Pharmaceutical research. 16(3)
The objective of this research was to investigate the substrate specificity of large neutral amino acid carrier (LNAA) and di/tripeptide (hPEPT1) transporters with respect to PD 158473, an NMDA antagonist.Cellular uptake studies were carried out usin
Publikováno v:
Pharmaceutical research. 15(9)
This study characterized the cellular uptake mechanism and hydrolysis of the amino acid ester prodrugs of nucleoside antiviral drugs in the transiently transfected Caco-2 cells overexpressing a human intestinal peptide transporter, hPEPT1 (Caco-2/hPE
Autor:
H, Han, R L, de Vrueh, J K, Rhie, K M, Covitz, P L, Smith, C P, Lee, D M, Oh, W, Sadée, G L, Amidon
Publikováno v:
Pharmaceutical research. 15(8)
General use of nucleoside analogues in the treatment of viral infections and cancer is often limited by poor oral absorption. Valacyclovir, a water soluble amino acid ester prodrug of acyclovir has been reported to increase the oral bioavailability o