Zobrazeno 1 - 10
of 94
pro vyhledávání: '"D M Grennan"'
Publikováno v:
Annals of the Rheumatic Diseases. 60:214-217
OBJECTIVES To determine whether continued methotrexate treatment increases the risk of postoperative infections or of surgical complications in patients with rheumatoid arthritis (RA) within one year of elective orthopaedic surgery. DESIGN A prospect
Publikováno v:
Annals of the Rheumatic Diseases. 49:763-767
A higher prevalence of C4B null alleles is found in Felty's syndrome. The molecular basis of C4 null alleles was investigated by studying restriction fragment length polymorphisms (RFLPs) obtained with C4 and 21-hydroxylase (21-OH) DNA probes and by
Publikováno v:
Rheumatology. 30:217-219
Articular disease severity as measured by a radiographic score of hands and feet was compared in rheumatoid subjects with (21) and without (170) Felty's syndrome. Disease duration was a major determinant of joint destruction. When this was taken into
Publikováno v:
Rheumatology. 45:912-913
Publikováno v:
Annals of the Rheumatic Diseases. 64:650-651
Tumour necrosis factor α (TNFα) antagonists are now established as therapeutic agents for active rheumatoid arthritis (RA) resistant to conventional drug treatment.1 However, they decrease resistance to infection, including unusual infections such
Publikováno v:
Arthritis and rheumatism. 38(1)
To determine whether an allelic form of mannose-binding protein (MBP) incapable of activating complement is associated with susceptibility to systemic lupus erythematosus (SLE).MBP allele frequencies were determined by amplification refractory mutati
Publikováno v:
Disease markers. 11(1)
The aim of this study was to examine the relationship between HLA-DP and susceptibility to articular and extra-articular features (Felty's syndrome and vasculitis) of rheumatoid arthritis (RA). The possible association of DP types with severity of ar
Publikováno v:
Experimental and clinical immunogenetics. 10(3)
Restriction fragment length polymorphisms (RFLPs) of C kappa, V kappa II, V lambda VII and VHIII genes were studied from a pool of 104 subjects with rheumatoid arthritis and 96 controls. There were no overall associations with either rheumatoid arthr
Publikováno v:
Disease markers. 10(3)
PIZ allele frequencies were defined by PCR amplification and hybridization using a PIZ SSO (sequence specific oligonucleotide) probe. The groups studied included 64 normal controls, 104 subjects with rheumatoid arthritis (RA) without any extra-articu
Autor:
D. M. Grennan, J. R. Green
Publikováno v:
Annals of human genetics. 55(3)
SUMMARY Testing for the inheritance of a disease susceptibility gene by analysis of haplotype sharing among affected siblings has been well established for the case where all four parental haplotypes have been ascertained. This paper presents a modif