P-glycoprotein and multidrug resistance protein activities in relation to treatment outcome in acute myeloid leukemia

Autor: D M, van der Kolk, E G, de Vries, W J, van Putten, L F, Verdonck, G J, Ossenkoppele, G E, Verhoef, E, Vellenga

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(8)

Despite treatment with intensive chemotherapy, a considerable number of patients with acute myeloid leukemia (AML) die from their disease due to the occurrence of resistance. Overexpression of the transporter proteins P-glycoprotein (P-gp) and multid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cf869d1a22b3480653d34b7b3f6d4396
https://pubmed.ncbi.nlm.nih.gov/10955805

Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines

Autor: G L, Scheffer, M, Maliepaard, A C, Pijnenborg, M A, van Gastelen, M C, de Jong, A B, Schroeijers, D M, van der Kolk, J D, Allen, D D, Ross, P, van der Valk, W S, Dalton, J H, Schellens, R J, Scheper

Publikováno v: Cancer research. 60(10)

Tumor cells may display a multidrug resistant phenotype by overexpression of ATP-binding cassette transporters such as multidrug resistance (MDRI) P-glycoprotein, multidrug resistance protein 1 (MRP1), and breast cancer resistance protein (BCRP). The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1813380e63045c31cdfc3ce59d7717d6
https://pubmed.ncbi.nlm.nih.gov/10825126

Activity and expression of the multidrug resistance proteins MRP1 and MRP2 in acute myeloid leukemia cells, tumor cell lines, and normal hematopoietic CD34+ peripheral blood cells

Autor: D M, van der Kolk, E G, de Vries, J A, Koning, E, van den Berg, M, Müller, E, Vellenga

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 4(7)

To develop a functional assay for the activity of the multidrug resistance protein 1 (MRP1), we tested whether carboxyfluorescein (CF) was specifically transported by MRP and whether this transport pump could be specifically blocked by the leukotrien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ad26163e40e9a1fc13cfc1fba4c2aece
https://pubmed.ncbi.nlm.nih.gov/9676848

Chemical Recording of Pump-Specific Drug Efflux in Living Cells.

Autor: Sun X; School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, The State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, 100871, China., Chen Y; College of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences and MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100193, China., Yang C; School of Medicine, Tsinghua University, Beijing, 100871, China., Yang S; College of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences and MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China., Lin W; College of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences and MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China., Quan B; College of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences and MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China., Pan X; School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, The State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, 100871, China., Ding Q; School of Medicine, Tsinghua University, Beijing, 100871, China., Chen X; College of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences and MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China., Wang C; College of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences and MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China., Qin W; School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, The State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, 100871, China.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Sep 26, pp. e202409282. Date of Electronic Publication: 2024 Sep 26.

Expression of nestin, CD133 and ABCG2 in relation to the clinical outcome in pediatric sarcomas.

Autor: Zambo, Iva^1,2, Hermanova, Marketa¹, Zapletalova, Danica³, Skoda, Jan^2,3,4, Mudry, Peter³, Kyr, Michal^2,3, Zitterbart, Karel³, Sterba, Jaroslav³, Veselska, Renata^2,3,4 veselska@sci.muni.cz

Publikováno v: Cancer Biomarkers. 2016, Vol. 17 Issue 1, p107-116. 10p.