Výsledky vyhledávání - "D M, Sheehan"

ChemInform Abstract: Evaluation of Quantitative Structure-Activity Relationship Methods for Large-Scale Prediction of Chemicals Binding to the Estrogen Receptor

Autor: W. TONG, D. R. LOWIS, R. PERKINS, Y. CHEN, W. J. WELSH, D. W. GODDETTE, T. W. HERITAGE, D. M. SHEEHAN

Publikováno v: ChemInform. 29

Three different QSAR methods, Comparative Molecular Field AnaIysis (CoMFA), classical QSAR (utilizing the CODESSA program), and Hologram QSAR (HQSAR), are compared in terms of their potential for screening large data sets of chemicals as endocrine di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0377833911f1d30bc7d932e3f497aa60
https://doi.org/10.1002/chin.199845276

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Comparative molecular field analysis (CoMFA) model using a large diverse set of natural, synthetic and environmental chemicals for binding to the androgen receptor

Autor: Weida Tong, D. M. Sheehan, H. Hong, Q. Xie, R. Perkins, H. Fang

Publikováno v: SAR and QSAR in environmental research. 14(5-6)

A large number of natural, synthetic and environmental chemicals are capable of disrupting the endocrine systems of experimental animals, wildlife and humans. These so-called endocrine disrupting chemicals (EDCs), some mimic the functions of the endo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf48cde27bcee4b0450093bbd4adff9
https://pubmed.ncbi.nlm.nih.gov/14758981

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Differential activity of diethylstilbestrol versus estradiol as neonatal endocrine disruptors in the female hamster (Mesocricetus auratus) reproductive tract

Autor: W J, Hendry, B L, DeBrot, X, Zheng, W S, Branham, D M, Sheehan

Publikováno v: Biology of reproduction. 61(1)

The synthetic estrogen diethylstilbestrol (DES) is a potent neonatal endocrine disruptor in the hamster. To test the specificity of this phenomenon, newborn animals were treated with 100 microgram of either DES or the natural estrogen, estradiol-17be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::25414ffa3ccbdbcae86542caeb3dde25
https://pubmed.ncbi.nlm.nih.gov/10377036

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Tissue-specific expression of messenger ribonucleic acids for insulin-like growth factors and insulin-like growth factor-binding proteins during perinatal development of the rat uterus

Autor: Y, Gu, W S, Branham, D M, Sheehan, P J, Webb, C L, Moland, R D, Streck

Publikováno v: Biology of reproduction. 60(5)

Insulin-like growth factor (IGF)-I and IGF-II play a number of important roles in growth and differentiation, and IGF-binding proteins (IGFBPs) modulate IGF biological activity. IGF-I has been shown previously to be essential for normal uterine devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bcaf760f9183b1b82f8ee336ea25fb2d
https://pubmed.ncbi.nlm.nih.gov/10208980

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Effects of toremifene on neonatal rat uterine growth and differentiation

Autor: K L, Medlock, W S, Branham, D M, Sheehan

Publikováno v: Biology of reproduction. 56(5)

In the developing rodent uterus, the estrogen agonist activity of triphenylethylene antiestrogens such as tamoxifen alters uterine luminal epithelium morphology and inhibits uterine gland genesis. We examined uterine growth and differentiation in fem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e1a4442d61ca8a399a50208c9cd029d5
https://pubmed.ncbi.nlm.nih.gov/9160724

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